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Membership type: full

Rawia Khalil

Country of origin: Egypt Currently in: Egypt, Cairo General field of specialization: Other
Academic Background

Degrees

1960 Doctorate Biological Systems and Organisms
Research and Profession

Current Research Activities

Other

Drug formulation Pharmaceutical technology Application of nanotechnology in drug delivery

Research Keywords: 
another

Publications resulting from Research: 


1- Salama, H.A., El-Nimir, A.E, Khalil, R.M. and Kassem, M.A., Effect of certain polymers on the activity of ophthalmic solutions of pilocarpine and homatropine in man (1982)Bull. N.R.C., Egypt., 7, 436 -442
2- El-Nimir, A.E, Salama, H.A., Khalil, R.M. and Kassem, M.A., Effect of urea on the activity of certain drugs in man. (1983). Pharmazie, 38, 728- 736
3- El-Nimir, A.E, Salama, H.A., El-Ridy, M.S. and Khalil, R.M., Release properties of iron from solid oral dosage forms relevant to formulation strategies (1989) 5th International Conference on Pharmaceutical Technology, Paris, Conference No. 14
4- El-Nimir, A.E, Kassem, M.A., Salama, H.A. and Khalil, R.M., A predictive in-vitro dissolution model for the bioavailability of iron from solid dosage forms 9th International Conference on Pharmaceutical Technology, Veldhoven, the Netherlands, April (1990).
5- Khalil, R.M., Complexation of paracetamol with xanthine derivatives (1992) Egypt J. Pharm. Sci., 33, 757 -766
6- Khalil, R.M., El-Nahas, S.A., Omar, S.M. and El-Ridy, M.S., Pilocarpine hydrochloride liposomal ophthalmic drug delivery system (1992) Egypt J. Pharm. Sci., 33, 667-673
7- Ammar, O.H., El-Nahas, S.A., Omar, S.M. and Khalil, R.M., Interaction of glucocorticoids with xanthines(1992) Egypt J. Pharm. Sci., 33, 981 -986
8- Ammar, N., Gaafar, S., and Khalil, R.M., Anti-inflammatory effect of natural steroids sapogenins on oral aphthus ulcers(1992).Egypt, Dental J. 38, 89 -95
9- Ammar, O.H., Khalil, R.M. and Omar, S.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method Part 1. Prednisolone tablets(1993) Pharmazie, 48, 57-62
10- Ammar, O.H. and Khalil, R.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method.Part 2. Paracetamol tablets Ibid, 48, 129 (1993).
11- Ammar, O.H. and Khalil, R.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method.Part 3. In-vitro / In-vivo correlation for paracetamol tablets. Ibid, 48, 136 (1993).
12- Ammar, O.H. and Khalil, R.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method. Part 4. Chlorpromazine hydrochloride tablets Ibid, 48, 927 (1993).
13- Ammar, O.H., Khalil, R.M. and Omar, S.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method. Part 5. In-vitro/ In-vivo correlation for Chlorpromazine hydrochloride tablets. Ibid, 48, 932 (1993).
14- Ammar, O.H. and Khalil, R.M., Effect of aromatic hydrotopes on the solubility of phenacetin. Part 1. Effect of sodium salts of hydroxyl and amino derivatives of benzoic acid.(1993) Ibid, 48, 842 -848
15- Ammar, O.H. and Khalil, R.M., Effect of aromatic hydrotopes on the solubility of phenacetin. Part 2. Effect of nicotinamide and sodium salts of benzoic, naphtholic and nicotinic acids.(1993) Ibid, 48, 845 -855
16- Khalil, R.M., Omar, S.M., El-Nahas, S.A. and Salama, H.A., Rheological studies on macaloid dispersions. Part 1. Effect of electrolyte(1994) Ibid, 49, 262-270
17- Ammar, O.H., El-Nahas, S.A., Khalil, R.M. and Omar, S.M., Solubilization of allopurinol with xanthines (1994) Ibid, 49, 839
18- Ammar, O.H., El-Nahas, S.A., Omar, S.M. and Khalil, R.M., Interaction of allopurinol with phenylepherine and certain analgesics (1994) J. Drug, Res. Egypt, 21, 65 -71
19- Omar, S.M., El-Nahas, S.A., Khalil, R.M. and Salama, H.A., Effect of polyethylene glycols on the rheological characteristics on macaloid dispersions Polymeric (1994) Ibid, 21, 91
20- El-Nahas, S.A., Khalil, R.M., Omar, S.M. and Salama, H.A., Rheological studies on macaloid dispersions. Part 2. Effect of surface active agents (1995) Pharmazie, 50, 410
21- Ammar, O.H. and Khalil, R.M., Effect of aromatic hydrotopes on the solubility of oxamniquine Part. Effect of sodium salts of hydroxyl and amino derivatives of benzoic acid.(1995) Ibid, 50, 809
22- Ammar, O.H. and Khalil, R.M., Effect of aromatic hydrotopes on the solubility of oxamniquine Part 2. Effect of nicotinamide and sodium salts of benzoic, naphtholic and nicotinic acids (1996) Ibid, 51, 490 -493
23- Ammar, O.H. and Khalil, R.M., Discrepancy among the dissolution rates of commercial tablets as a function of the dissolution method. Part 6. Rifampicin (1996) Ibid, 51, 165
24- Khalil, R.M., Murad, F.E., Yehia, S.A., El-Ridy, M.S. and Salama, H.A., Free versus liposome-entrapped streptomgcin sulfate in treatment of infections caused by salmonella enteritidis Pharmazie,(1996) 51, 182
25- Khalil, R.M., Interaction of ibuprofen and indomethacin with caffeine(1996) Ibid, 51, 970
26- Ammar, O.H. and Khalil, R.M., Solubilization of certain analgesi cetomacrogol 1000(1996) Egypt J. Pharm. Sci., 37, 261
27- El-Ridy, M.S., Khalil, R.M., Moustafa, D.M., Mohamed, El-Rasdy, M., Osman, A., Gaber, M.H. and Monem, A.S., Chemoprophylaxis of schistosomiasis using liposome encapsulated oxamniquine(1997). Drug Dev. Ind. Pharm., 23, 771
28- Khalil, R.M., Interaction of hydrocortisone with gentisate hydrotopes
(1997) Pharmazie, 52, 866
29- Ammar, O.H., Khalil, R.M. and El-Nahas, S.A., Dissolution rate measurements as a predictory tool for assessing comparative bioavailability of generic ampicillin capsules.(1997) Egypt J. Pharm. Sci., 38, 527
30- Ammar, O.H. and Khalil, R.M., Preparation and evaluation of sustained release solid dispersions of drugs with eudragit polymers
(1997) Drug Dev. Ind. Pharm., 23, 1043
31- Ammar, O.H., El-Nahas, S.A.and Khalil, R.M., Cyclodextrins in acetazolamide eye drops formulations(1998) Pharmazie, 53, 559
32- Salama, H. A., Ammar, H. O. and Khalil, R. M., Liposomal delivery systems in hydrocortisone eye drops formulation (1998) Egypt. J. Pharm. Sci., 39, 19-30
33- Salama, H. A., Ammar, H. O. and Khalil, R. M., Liposomal delivery systems in timolol maleate eye drops formulation (1998) Egypt. J. Pharm. Sci., 39, 109-121
34- El-Ridy, M. S. and Khalil, R. M., Free versus liposomal – encapsulated lignocaine hydrochloride topical application (1999) Pharmazie, 54, 682
35- Khalil, R. M., Mostafa, D. M. and Kassem, M. A. Inclusion complexes of folic acid with B-cyclodextrin and hydroxyl propyl B-cyclodextrin (2004)Egypt. J. Pharm. Sci., 45, 79
36- Mostafa, D. M., Khalil, R. M. and Kassem, M. A., Inclusion Complexes of Meloxicam and Cyclodextrins(2008) BULL. NRC, Egypt, 33, 35
37- Kassem, M.A., Abdel Rahman, A.A., Ghorab, M.M., Ahmed, M.B., Khalil, R.M., . Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs. (2007) Int. J. Pharm., 340, 126-133
38- Ahmed Abd Elbary, Mahfouz A. Kassem, Mona M. Abou Samra, Rawia M. Khalil., Formulation and hypoglycemic activity of pioglitazone –cyclodextrin inclusion complexes(2008) Drug Discov. Ther., 2 (2), 94-107
39- El-Ridy, M.S., Abdelbary, A., Khalil, R.M. and Kassem, A.A.A., Niosomal Encapsulation of the Tuberculocidal Drug Rifampicin (2008) Egypt, Pharm. J. (NRC), 7, 69-76
40- R.M. Kalil, M.M. Ghorab, N. Abd El-Rahman and S. Kocova El-Arini, Enhancement of Dissolution of Nimesulide Using a novel Surface-Active Polymeric Carrier, Inutec® SP1(2010)Egypt. Pham. J. (NRC) 9 (2) 181-201
41- M. S. El-Ridy, A. Abdelbary, E.A.Nasr, R.M.Khalil, D.M.Mostafa, A. I. El-Batal, and S. H. Abd El-Alim. . Niosomal encapsulation of the antitubercular drug pyrazinamide (2011) Drug Development and Industrial Pharmacy; 37(9):1110–1118
42- Rawia M. Khalil, Fahima M. Hashem, Heba S. Zaki, Silvia Kocova El-Arini, Mona Basha and Sayed Z. Salem, Topical colchicines film for the treatment of Alopecia Areata (2012)Egypt. J. Dermatology and Venereology, 32:20-27
43- Rawia M. Khalil, A. Abd-Elbary, Mahfoz A. Kassem1, Mamdouh M. Ghorab3, and Mona Basha. Nanostructured lipid carriers (NLCs) versus solid lipid nanoparticles (SLNs) for topical delivery of meloxicam(2014) Pharm. Dev. Technol.19(3):304-14.(1.34)
44- Rawia M. Khalil, Ahmed Abd El-Baryb, Mahfoz A. Kassema, Mamdouh M. Ghorabc and Mona Bashaa. Influence of formulation parameters on physicochemical properties of meloxicam-loaded solid lipid nanoparticales (2013) Egyptian Pharmaceutical Journal 12, 63-72
45- Rawia M Khalil, Fahima M Hashem, Heba S Zaki, Silvia Kocova El- Arini, Mona B Ahmed, Sayed Z Salem. Development of a Novel Topical Colchicine Film and Evaluation of its Clinical Efficacy in Patients with Alopecia Areata(2012) Inventi Impact: Pharm Tech , Vol. 2013 , Article ID- " Inventi:ppt/633/12 " Available Fromhttp://www.inventi.in/Article/ppt/633/12.aspx
46- Rawia M. Khalil, Mamdouh M. Ghorabb, Noha Abd El-Rahmana and Silvia Kocova El-Arinia. Characterization of ternary solid dispersions of nimesulide with Inutec SP1 and b-cyclodextrin and evaluation of anti-inflammatory efficiency in rats.(2013) Egyptian Pharmaceutical Journal.12,46-56
47- Rawia M. Khalil, Ahmed Abd El-Barry,Mahfoz A. Kassem, Mamdouh M. Ghorab, Mona B Ahmed.Solid lipid nanoparticles for topical delivery of meloxicam: development and in vitro characterization 1st Annual International Interdisciplinary Conference, AIIC 2013, 24-26 April, Azores, Portugal – Proceedings 779-798-(Conference place: University of the Azores, Ponta Delgada) (European Scientific Journal (ESJ) june 2013 special edition No.3 )
48- Rawia Khalil, Mahfouz Kassem, Ahmed A. Elbary, Mohamed El Ridi and Mona AbouSamra , Preparation and characterization of nystatin-loaded solid lipid nanoparticles for topical delivery (2013) International Journal of Pharmaceutical Sciences and Research (IJPSR) 4(6): 2292-2300.(Impact factor 2.44 El SEVIER)
49- Rawia M. Khalil, A. Abd- Elbary, Mahfouz A. Kassem,Mohamed S. El Ridy, Mona M. Abou Samra, Ghada E. A. Awad and Soheir S. Mansy, Formulation and Characterization of Nystatin loaded Nanostructured Lipid Carriers for Topical Delivery against Cutaneous Candidiasis (2014)British Journal of Pharmaceutical Research (BJPR),4(4): 490-512. .(Impact factor 1.24ELSEVIER)

(Science Domain International)
50- Rawia Khalil, Fahima Hashem, Heba Zaki1, Silvia El-Arini, Polymeric nanoparticles as potential carriers for topical delivery of colchicine: development and in vitro characterization IJPSR, 2014; Vol. 5(5):1746- 1756. .(Impact factor 2.44 ELSEVIER)

51- Rawia M. Khalil, Ahmed A. Abd El Rahman, Mahfouz A. Kassem, Mohamed S. El Ridi, Mona M. Abou Samra, Ghada E. A. Awad, Soheir S. Mansy. Preparation and in vivo Assessment of Nystatin-Loaded Solid Lipid Nanoparticles for Topical Delivery against Cutaneous Candidiasis (2014), International Journal of Medical, Health, Pharmaceutical and Biomedical Engineering Vol:8 No:7,390-398, (World Academy of Science, Engineering and Technology)(impact factor 1.5)
52- Ibrahim A. El-said1, Ahmed A. Aboelwafa1, , Rawia M. Khalil , and Omaima N. ElGazayerly1. Baclofen novel gastroretentive extended releas gellan gum superporous hydrogel hybrid system: in vitro and in vivo evaluation. Drug Deliv, Early Online: 1–12 ! 2014 Informa Healthcare USA, Inc. DOI: 10.3109/10717544.2014.9056 http://informahealthcare.com/drd
ISSN: 1071-7544 (print), 1521-0464 (electronic).
53-M.S. El-Ridy *1, A.A. Abd ElRahman 2, G.M. Awad 3, R.M. Khalil 1 and M.M. Younis IN-VITRO AND IN-VIVO EVALUATION OF NIOSOMES CONTAINING CELECOXIB . IJPSR, 2014; Vol. 5(11): 4677-4688. .(Impact factor 2.44 ELSEVIER)
54- Samar M.Abouelatta, Ahmed A. Aboelwafa1 Rawia M. Khalil and Omaima N. ElGazayerly. Floating lipid beads for the improvement of bioavailability of poorly soluble basic drugs: In-vitro optimization and in- vivo performance in humans. European Journal of Pharmaceutics and Biopharmaceutics(2015)89:82-92. http://dx.doi.org/10.1016/j.ejpb.2014.11.011

55-Samar M. Abouelatta, Ahmed A. Aboelwafa, Rawia M. Khalil, Omaima N.El-Gazayerly ,Utilization of ionotropic gelation technique for bioavailability enhancement of cinnarizine: in-vitro optimization and in-vivo performance in human, Drug Deliv, Early Online: 1–11! 2015 Informa Healthcare USA, Inc.DOI:3109/10717544.2015.1064187.
































Current profession

• Head of department of pharmaceutical technology, National Research Centre (NRC) Cairo, Egypt. • PHD of pharmaceutical science, college of pharmacy, Cairo University (1989). • Member of the permanent scientific committee for promotion of research staff members, NRC. • Principal investigator, CO-Principal Investigator and Participant in many research projects in NRC. • Member in Egyptian Association and Syndicate of Pharmacists in Egypt.

Workshop and Conference Attended

July 30 -31, 2014. Zurich , Switzerland - ICPPS 2014 : International Conference on Pharmacy and Pharmaceutical Sciences

Affiliations

Syndicate of Pharmacists

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