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Membership type: full

Rasheeba Nizam

Country of origin: India Currently in: Kuwait, Kuwait City General field of specialization: Structural, Cell and Molecular Biology
Academic Background

Degrees

Structural, Cell and Molecular Biology
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

My current research is intrigued on understanding the atieopathogenesis of complex polygenic and rare single gene disorders in Kuwait. I keep a broader investigative view towards these needs by actively exploring their root causes. My publications have been centered on linking molecular mechanisms underlying polymorphism to specific diseases like beta thalassemia, sickle cell anemia, lupus, rheumatoid arthritis, diabetes, obesity and psoriasis. My long term research interest includes understanding the root cause of inflammatory diseases such as psoriasis, autism and diabetes, due to its outpacing prevalence in this region.

Research Keywords: 
research
genomics
molecular biology

Publications resulting from Research: 


1. AlFadhli S, Al-Mutairi M, Al Tameemi B, Rasheeba Nizam (2016) Influence of MX1 promoter rs2071430 G/T polymorphism on susceptibility to systemic lupus erythematosus. Clinical Rheumatology Mar;35(3):623-9.

2. AlFadhli S, Ghanem A, Rasheeba Nizam (2015) Genome-wide peripheral Blood transcriptome analysis of Arab female Lupus and Lupus nephritis. GENE pii: S0378-1119(15)00728-3.
3. AlFadhli S, Ghanem A, Rasheeba Nizam (2015) Genome-wide differential expression reveals candidate gene involved in the pathogenesis of Lupus and Lupus nephritis. International journal of rheumatic diseases. doi: 10.1111/1756-185X.12745

4. Suad AlFadhli, Rasheeba Nizam (2014) Differential expression of alternative splice variants of CTLA4 in Kuwaiti autoimmune disease patients. GENE 534 (2):307–312.

5. Suad AlFadhli, Rasheeba Nizam (2014) Rhupus: A crosswalk between lupus and rheumatoid arthritis. OA Arthritis 10; 2(1):3.

6. Suad AlFadhli, Rasheeba Nizam (2014) Violating the theory of single gene-single disorder: Inhibitor development in hemophilia. I J Blood transfusion and medicine
31(2):162-8.

7. Suad AlFadhli, Mays Hadi, Mashael Al-Mutairi, Rasheeba Nizam (2013) Effect of UGT1A1 Promoter Polymorphism in the Development of Hyperbilirubinemia and Cholelithiasis in Hemoglobinopathy Patients. PLOS ONE 8(10): e77681.

8. Suad AlFadhli, Matra Salem, Shome DK, Najat Mahdi, Rasheeba Nizam (2015) The effects of mutations in HFE and SLC40A1 genes on biochemical parameters of Iron status in Arab Beta-Thalassemia patients. (under review).

9. Suad AlFadhli, Rasheeba Nizam (2015) Association of PTPN22 and STAT4 polymorphisms with lupus and overlapping autoimmunity in a Kuwaiti Population. (under review).



Current profession

Current professional activities type: 
Research
My research is intrigued on understanding the atieopathogenesis of complex polygenic and rare single gene disorders in Kuwait. I keep a broader investigative view towards these needs by actively exploring their root causes. My publications have been centered on linking molecular mechanisms underlying polymorphism to specific diseases like beta thalassemia, sickle cell anemia, lupus, rheumatoid arthritis, diabetes, obesity and psoriasis. My long term research interest includes understanding the root cause of inflammatory diseases such as diabetes, psoriasis and autism, due to its outpacing prevalence in this region.

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