Member Profile
Membership type: full
Youssra Al-Hilaly
Country of origin: Iraq Currently in: Iraq, Baghdad General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2014 Doctorate Structural, Cell and Molecular Biology2003 Master Chemical Sciences -
Current Research Activities
Structural, Cell and Molecular Biology
Publications resulting from Research:
Article
1. Youssra K. Al‐Hilaly; Bronwen E. Foster; Luca Biasetti; Liisa Lutter; Saskia J Pollack; Janet E. Rickard; John M.D. Storey; Charles R. Harrington; Wei‐Feng Xue; Claude M. Wischik; Louise C. Serpell (2019) Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain. FEBS Letters.
2. Al-Hilaly, Youssra K, Pollack, Saskia J, Rickard, Janet E, Simpson, Michael, Raulin, Ana-C, Baddeley, Thomas, Schellenberger, Pascale, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2018) Cysteine-independent inhibition of alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT). Journal of Molecular Biology, 430 (21). pp. 4119-4131. ISSN 0022-2836
3. Al-Hilaly, Youssra K, Pollack, Saskia J, Vadukul, Devkee, Citossi, Francesca, Rickard, Janet E, Simpson, Michael, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2017) Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking. Journal of Molecular Biology, 429 (4). pp. 3650-3665. ISSN 0022-2836
4. Al-Hilaly, Youssra K, Biasetti, Luca, Brakeman, Ben J, Pollack, Saskia J, Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R, Xue, Wei-Feng and Serpell, Louise C (2016) The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease. Scientific Reports, 6. p. 39171. ISSN 2045-2322
5. Marshall, Karen E, Vadukul, Devkee M, Dahal, Liza, Theisen, Alina, Fowler, Milena W, Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J, Staras, Kevin and Serpell, Louise (2016) A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration. Scientific Reports, 6. ISSN 2045-2322
6. Bukar Maina, Mahmoud, Al-Hilaly, Youssra and Serpell, Louise (2016) Nuclear tau and its potential role in Alzheimer’s disease. Biomolecules, 6 (1). 9 1-20. ISSN 2218-273X
7. Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William, Morris, Kyle L, Sada, Alaa, Thorpe, Julian R and Serpell, Louise C (2013) A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease. Acta Neuropathologica Communications, 1 (83). pp. 1-17. ISSN 2051-5960
8. Muslih, Raad K., Al-Kazzaz, Fatin F., Al-Hilaly Youssra K, (2012) Separation and Study Isoenzymes of Soluble Acetyl Cholinesterase in Nromal Human Brain and Gliomas Tumors. Al-Qadisiyah Journal of Pure Science, [S.l.], v. 17, n. 1, p. 112-120, ISSN 2411-35
Book Section
Vadukul, Devekee M, Al-Hilaly, Youssra K and Serpell, Louise C (2018) Methods for structural analysis of amyloid fibrils in misfolding diseases. In: Gomes, Cláudio M (ed.) Protein misfolding diseases. Humana Press, New York, NY, pp. 109-122. ISBN 9781493988198
Workshop and Conference Attended
2018 UK Protein disulphide bonds: biochemistry, biotechnology and biomedical impact ConferenceAffiliations
Alzheimer Research UK south coast networkBiochemical society, UKRoyal Society of Biology (RSB)Iraqi Society of Clinical BiochemistryPresentation given
2018Alzheimer’s disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linkingUK, University of KentEvent: Protein disulphide bonds: biochemistry, biotechnology and biomedical impact conference -
Other Awards
Jul 2018Biochemical Society Early Career Bursary