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Member Profile

Membership type: full

Soledad Astrada

Country of origin: Uruguay Currently in: Uruguay, Montevideo General field of specialization: Structural, Cell and Molecular Biology
Academic Background

Degrees

2016 Doctorate Structural, Cell and Molecular Biology
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

PhD

Research Keywords: 
Cancer
Bioactive peptides
cellular biology

Publications resulting from Research: 


Astrada S, Fernández Massó JR, Vallespí MG, Bollati-Fogolín M. Cell
Penetrating Capacity and Internalization Mechanisms Used by the Synthetic Peptide
CIGB-552 and Its Relationship with Tumor Cell Line Sensitivity. Molecules. 2018
Mar 30;23(4). pii: E801. doi: 10.3390/molecules23040801. PubMed PMID: 29601540;
PubMed Central PMCID: PMC6017325.

Sena F, Sotelo-Silveira M, Astrada S, Botella MA, Malacrida L, Borsani O.
Spectral phasor analysis reveals altered membrane order and function of root hair
cells in Arabidopsis dry2/sqe1-5 drought hypersensitive mutant. Plant Physiol
Biochem. 2017 Oct;119:224-231. doi: 10.1016/j.plaphy.2017.08.017. Epub 2017 Aug
26. PubMed PMID: 28910707.

Astrada S, Gomez Y, Barrera E, Obal G, Pritsch O, Pantano S, Vallespí MG,
Bollati-Fogolín M. Comparative analysis reveals amino acids critical for
anticancer activity of peptide CIGB-552. J Pept Sci. 2016 Nov;22(11-12):711-722.
doi: 10.1002/psc.2934. PubMed PMID: 27933724.

Malacrida L, Astrada S, Briva A, Bollati-Fogolín M, Gratton E, Bagatolli LA.
Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study
the hydration and time evolution of intracellular lamellar body-like structures.
Biochim Biophys Acta. 2016 Nov;1858(11):2625-2635. doi:
10.1016/j.bbamem.2016.07.017. Epub 2016 Jul 30. PubMed PMID: 27480804; PubMed
Central PMCID: PMC5045802.

Mastropietro G, Tiscornia I, Perelmuter K, Astrada S, Bollati-Fogolín M. HT-29
and Caco-2 reporter cell lines for functional studies of nuclear factor kappa B
activation. Mediators Inflamm. 2015;2015:860534. doi: 10.1155/2015/860534. Epub
2015 Mar 10. PubMed PMID: 25861164; PubMed Central PMCID: PMC4377483.

León IE, Porro V, Astrada S, Egusquiza MG, Cabello CI, Bollati-Fogolin M,
Etcheverry SB. Polyoxometalates as antitumor agents: Bioactivity of a new
polyoxometalate with copper on a human osteosarcoma model. Chem Biol Interact.
2014 Oct 5;222:87-96. doi: 10.1016/j.cbi.2014.10.012. Epub 2014 Oct 22. PubMed
PMID: 25451568.

Vallespí MG, Pimentel G, Cabrales-Rico A, Garza J, Oliva B, Mendoza O, Gomez
Y, Basaco T, Sánchez I, Calderón C, Rodriguez JC, Markelova MR, Fichtner I,
Astrada S, Bollati-Fogolín M, Garay HE, Reyes O. Antitumor efficacy,
pharmacokinetic and biodistribution studies of the anticancer peptide CIGB-552 in
mouse models. J Pept Sci. 2014 Nov;20(11):850-9. doi: 10.1002/psc.2676. Epub 2014
Jul 20. PubMed PMID: 25044757.

Fernández-Calero T, Astrada S, Alberti A, Horjales S, Arnal JF, Rovira C,
Bollati-Fogolín M, Flouriot G, Marin M. The transcriptional activities and
cellular localization of the human estrogen receptor alpha are affected by the
synonymous Ala87 mutation. J Steroid Biochem Mol Biol. 2014 Sep;143:99-104. doi:
10.1016/j.jsbmb.2014.02.016. Epub 2014 Mar 4. PubMed PMID: 24607813.

Noya V, Bay S, Festari MF, García EP, Rodriguez E, Chiale C, Ganneau C, Baleux
F, Astrada S, Bollati-Fogolín M, Osinaga E, Freire T. Mucin-like peptides from
Echinococcus granulosus induce antitumor activity. Int J Oncol. 2013
Sep;43(3):775-84. doi: 10.3892/ijo.2013.2000. Epub 2013 Jun 28. PubMed PMID:
23817837.

Fernández Massó JR, Oliva Argüelles B, Tejeda Y, Astrada S, Garay H, Reyes O,
Delgado-Roche L, Bollati-Fogolín M, Vallespí MG. The Antitumor Peptide CIGB-552
Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells. J Amino Acids.
2013;2013:251398. doi: 10.1155/2013/251398. Epub 2013 Jan 16. PubMed PMID:
23401744; PubMed Central PMCID: PMC3562689.

Gascue C, Tan PL, Cardenas-Rodriguez M, Libisch G, Fernandez-Calero T, Liu
YP, Astrada S, Robello C, Naya H, Katsanis N, Badano JL. Direct role of
Bardet-Biedl syndrome proteins in transcriptional regulation. J Cell Sci. 2012
Jan 15;125(Pt 2):362-75. doi: 10.1242/jcs.089375. Epub 2012 Feb 2. PubMed PMID:
22302990; PubMed Central PMCID: PMC3283873.




Current profession

Current professional activities type: 
Research
PhD Student, Reseash Assistant