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Jalila Ben Salah-Abbes

Country of origin: Tunisia Currently in: Tunisia, Monastir General field of specialization: Biological Systems and Organisms
Academic Background

Degrees

2019 Biological Systems and Organisms
Research and Profession

Current Research Activities

Biological Systems and Organisms

In our scientific carrier we interested to the safety of food and feed for human and animals and the impact of mycotoxins in immune diseases. We usually, tray to answer the question: how we can use the contaminated cereals without risk for animals and Humans? And what are the best strategies using additives without risk from minerals, extract plants and bacteria to get rid against mycotoxin contaminant. We focused with our lab team to invent strategies based on natural product to eliminate mycotoxin problems by detoxification or inactivation in feedstuff, we achieved the following: - We interested in the biological effects of a clay mineral called montmorillonite collected from Tunisian environment in the area of food and feed detoxification. We concentrated to study this mineral as an anti-cating agent against Zearalenone (ZEN) contaminated feed for their physical and chemical properties, such as ion exchange capacity, adsorption and related molecular sieve properties. According to these properties, it is assumed that ZEN may partition into the hydrophobic phase created by surfactant tails at the montmorillonite surface and within the interlamellar space, a mechanism which may be responsible for the majority of the adsorption processes. Moreover, the used clay is friendly to the environment, cheap and not shown any toxic effects at the higher level doses and not poses significant hidden risks due to interaction with nutrients and other important feed borne chemicals. Furthermore, it’s effective against aflatoxins toxicities and used now as additive for animal contaminated diet in many Tunisian animal feed company and we propose to introduce a final product suitable for human consumption and to extrapolate this clay outside Tunisia to Afraican countries suffer from mycotoxin contamination feed and food. - We also have extracted and purified many bioactive compounds from Tunisian radish (Raphanus sativus). The most potential compound isolated from radish is the 4-(Methylthio)-3-butenyl isothiocyanate (MTBITC). This sulphurous compound has been evaluated for in vitro and in vivo study against ZEN toxicities. The in vitro study indicated that MTBITC was able to prevent many human cell lines against ZEN toxicities. Besides, we demonstrated that MTBITC is a strong anti-proliferative compound. It killed cancer cells by an ROS dependent apoptotic mechanism and neither increased ROS nor toxicity in normal cells, and is capable of modulating biotransformation enzyme activity and preventing certain cancers. The most pertinent results demonstrated in our research carrier are the antigenotxic effects of MTBITC against ZEN. The possible mechanism of protection offered by MTBITC against ZEN-genotoxicity is due to its ability to inhibit oxidative process by neutralizing reactive oxygen species as well as its interaction with estrogen receptors that are occupied by the mycotoxin ZEN. In addition, it could not be excluded that MTBITC acts as antigenotioxic complex which enhances the DNA repair system or DNA synthesis which is proved by the disappearance of the new DNA band caused by ZEN treatment. - In parallel we focused now to another axis related to using pro and prebiotic bacteria to reduce immunotoxicity for animals and humans related to mycotoxin ingestion. In summary, we have shown that MTBITC extracted from Tunisian R. Sativus, montmorillonite clay from national environment and probiotic bacteria isolates dairy exerts their chemoprotective abilities by binding, metabolisation and modulating the activities of ZEN-sensitive enzymes as well as protecting DNA from ZEN induced damage. These results may prove useful in developing MTBITC, clay and probiotic bacteria based chemoprotection regime and as an additive in food and feed contaminated diet.

Research Keywords: 
Biological control

Publications resulting from Research: 


 Article 1
Samir Abbès, Zouhour Ouanes, Jalila Ben Salah-Abbès, Zohra Houas, Ridha Oueslati, Hassen Bacha and Omar Othman (2006). The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by zearalenone in mice. Toxicon 47; 567-574.
 Article 2
Samir Abbès, Jalila Ben Salah-Abbès, Zouhour Ouanes, Zohra Houas, Omar Othman, Hassen Bacha, Mosaad A. Abdel-Wahhab, Ridha Oueslati (2006). Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in balb/c mice. International Immunopharmacology, 6; 1251-1258.
 Article 3
Samir Abbès, Jalila Ben Salah-Abbès, Zouhour Ouanes, Hassen Bacha, Omar Othman, Mosaad A. Abdel-Wahhab and Ridha Oueslati (2006). Hydrated sodium calcium aluminosilicate Protects Against Genotoxic Effects In Zearalenone-Treated Balb/C Mice. The Egy. J. of Hosp. Med. 22; 49-59. ISSN: 1687-2002/12084.
 Article 4
Samir Abbès, Zouhour Ouanes, Jalila Ben Salah-Abbès, Mosaad A. Abdel-Wahhab, Ridha Oueslati, Hassen Bacha (2007). Preventive role of aluminosilicate clay against micronuclei and chromosome aberration induction in bone marrow cells of Zearalenone treated Balb/c mice. Mutation research, 631; 85-92.
 Article 5
Samir Abbès, Jalila Ben Salah-Abbès, Kais Nahdi, Ridha Ben Younes, Mona M. Hetta, Ahmed A. El-Kady, Mosaad A. Abdel-Wahhab, Ridha Oueslati (2007). Inactivation of cadmium induced immunotoxicological alterations in rats by Tunisian montmorllonite clay. International Immunopharmacology, 7; 750-760.
 Article 6
Jalila Ben Salah-Abbès, Samir Abbès, Zouhour Ouanes, Zohra Houas, Mosaad A. Abdel-Wahhab, Hassen Bacha, Ridha Oueslati (2008). Tunisian radish extract (Raphanus sativus) enhances the antioxidant status and protects against oxidative stress induced by zearalenone in Balb/c mice. Journal of Applied Toxicology, 28; 6-14.
 Article 7
Jalila Ben Salah-Abbès, Samir Abbès, Zohra Houas, Mosaad A. Abdel-Wahhab, Ridha Oueslati (2008). Zearalenone induces immunotoxicity in mice: possible protective effects of Radish Extract (Raphanus Sativus). Journal of Pharmacy and Pharmacology, 60; 761-770

 Article 8
Samir Abbès, Jalila Ben Salah-Abbès, Zouhour Ouanes, Mouna M. Hetta, Mohamed Ibrahim, Hassen Bacha, Mosaad A. Abdel-Wahhab, Ridha Oueslati (2008). Efficacy of Tunisian montmorillonite to bind Aflatoxin in vitro and to ameliorate the physiological alteration in vivo. Applied clay science, 42; 151-157.
 Article 9
Jalila Ben Salah-Abbès, Samir Abbès, Mossad Attia Abdel-Wahhab, Ridha Oueslati (2009). Raphanus sativus extract protects against Zearalenone induced reproductive toxicity, oxidative stress and mutagenic alterations in male Balb/c mice. Toxicon 53; 525-533.
 Article 10
Jalila Ben Salah-Abbès, Samir Abbès, Zouhour Ouanes, Zohra Houas, Mossad Attia Abdel-Wahhab, Bacha H., Ridha Oueslati (2009). Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxicity of Zearalenone in vivo and in vitro. Mutation Research, 677; 59-65.
 Article 11
Jalila Ben Salah-Abbès, Samir Abbès, Mossad Attia Abdel-Wahhab, Ridha Oueslati (2009). Raphanus sativus extract prevents and ameliorates Zearalenone-induced peroxidative hepatic damage in Balb/c mice. Journal of Pharmacy and pharmacology 61:1545-1554.
 Article 12
Jalila Ben Salah-Abbès, Samir Abbès, Mossad Attia Abdel-Wahhab, Ridha Oueslati (2010). In vitro free-radical scavenging, antiplorifilative and anti-zearalenone cytotoxicity effects of 4-(Methylthio)-3-butenyl isothiocyanate from (Tunisian) Raphanus sativus. Journal of Pharmacy and Pharmacology, 62; 331-339.
 Article 13
Jalila Ben Salah-Abbès, Samir Abbès, Abdel-Wahhab MA, Ridha Oueslati, (2010) Immunotoxicity of Zearalenone in Balb/c mice in a high subchronic dosing study counteracted by Raphanus sativus extract. Journal of Immunopharmacology and Immunotoxicology 32; 628-636.
 Article 14
Samir Abbès, Jalila Ben Salah-Abbès, Mossad Attia Abdel-Wahhab, Ridha Oueslati (2010). Immunotoxicological and biochemical effects of Aflatoxins in rats prevented by Tunisian Montmorillonite with reference to HSCAS. Journal of Immunopharmacology and Immunotoxicology 32; 514-522.

 Article 15
Samir Abbès, Jalila Ben Salah-Abbès, Yousra Bouraoui, Ridha Oueslati (2012). Detection of natural occurance of aflatoxins (B1 and M1) in feed, Blood samples and raw milk of lactating dairy cows in Beja, Tunisia using ELISA test. Food additive and Contaminant: part B 5, 11-15.
 Article 16
Samir Abbès, Jalila Ben Salah-Abbès, Hakima Sharafi, Akbari NK, Oueslati R (2012). Interaction of Lactobacillus plantarum MON03 with Tunisian Montmorillonite clay and ability of the composite to immobilize Zearalenone in vitro and counteract immunotoxicity In vivo. Journal of Immunopharmacology and Immunotoxicology. 34, 944-950. (IF 2013= 1,109)
 Article 17
Samir Abbès, Jalila Ben Salah-Abbès, Hakima Sharafi, Jebali R, Akbari NK, Oueslati R. (2013). Ability of Lactobacillus rhamnosus GAF01 to Remove AFM1 in Vitro and to Counteract AFM1 Immunotoxicity in Vivo. Journal of Immunotoxicology. 10, 279-286.
 Article 18
Samir Abbès, Jalila Ben Salah-Abbès, Hakima Sharafi, Oueslati R, Akbari NK. (2013). Lactobacillus paracasei BEJ01 Prevents Immunotoxic Effects During Chronic Zearalenone Exposure in Balb/c Mice. Journal of Immunopharmacology and Immunotoxicology. 35, 341-348.
 Article 19
Jalila Ben Salah-Abbès, Samir Abbès, Haous Zohra, Oueslati R. (2013). Tunisian Radish (Raphanus sativus) Extract Prevents Cadmium-induced Immunotoxic and Biochemical Alterations in Rats. Journal of Immunotoxicology 12, 40-47.
 Article 20
Jalila Ben Salah-Abbès, Samir Abbès, Rania Jebali, Zohra Haous, and Ridha Oueslati. (2014). Potential Preventive Role of Lactic Acid Bacteria Against Aflatoxin M1 Immunotoxicity and Genotoxicity in Mice. Journal of Immunotoxicology 12, 107-114.
 Article 21
Jebali Raniaǂ, Samir Abbèsǂ, Jalila Ben Salah-Abbès, Ben Younes R, Haouas Zohra, Oueslati Ridha. (2014) Ability of Lactobacillus plantarum MON03 to mitigate Aflatoxins (B1 and M1) immunotoxicities in mice. Journal of Immunotoxicology 2, 1-10.
 Article 22
Samir Abbès, Jalila Ben Salah-Abbès, Rania Jebali, Ben Younes Ridha, Oueslati Ridha. (2014) Interaction of Aflatoxin B1 and Fumonisin B1 in Mice Causes Immunotoxicity and Oxidative Stress: Possible Protective Role using Lactic Acid Bacteria Journal of Immunotoxicology 14, 1-9.
 Article 23
Jalila Ben Salah-Abbès, Samir Abbès, Hakimeh Sharafi, Kambiz Akbari Noghabi, Ridha Oueslati (2015). Physiological alteration of AFB1 in Rats counteracted by Lactobacillus paracasei BEJ01and montmorillonite clay supplementation (soumis for publication)



Current profession

Current professional activities type: 
Research
Teaching
-Teaching courses of Immunology - Doing research related to food contaminants -Supervise master and PhD students - Active member in many scientific societies - General secretary of Tunisan society of psych-neuro-endicrino Immunoogy (AT-PNEI)

Workshop and Conference Attended

2006 Cairo, Egypte The Pan-Arab Conference of The Egyptian Society of pediatric Gastroenterology, Hepatology & nutrition.
2006 GEUMSAN, KOREA 9th International Symposium on ginseng
2006 Institut Pasteur / Paris Frence Congrès Annuel de la Société Française de Toxicologie «Toxicologie de la Pharmacodépendanceaux Médicaments et aux Drogues»: , .
2009 Baltimore, USA Society of Toxicology meeting,
2010 Barcelona, Espagne International Congress of Toxicology,
21-22 April 2012 Bibliotheca Alexandrina, Egypt. the Academy of Sciences for the developing world conference world/BioVision Next Alexandria. 2012 (TWAS/BVA.NXT 2012)
2012 Tianjin, China. 12th conference/23ème annual meeting of "the Academy of Sciences for the developing countries (TWAS)" .
2013 Buenos Aires, Argentine 13th conference/24ème annual meeting of "the Academy of Sciences for the developing countries (TWAS)" .
19-21 November 2013 Alexandria, Egypt Workshop “Researchers Ethics and Commercialization” , Bibliotheca Alexandrina,
2015 Bibliotheca Alexandrina, Alexandria, Egypt TWAS 11th Annual Meeting "Green Economy: A Road Map for Sustainable Development and Poverty Reduction in the Arab Region"

Affiliations

Faculty of Sciences of Bizerte, Research Unit IMEC

Presentation given

2012
Immunotoxicity and genotoxicity induced by Zearalenone: Possible protective effects by isothiocyanates extracted from Tunisian Raphanus sativus
Tianjin China
Event: TWAS 12thConference/23rd meeting
2008
GENOTOXICITY AND CLASTOGENICITY OF ZEARALENONE MYCOTOXIN: PREVENTIVE ROLE OF ALUMINOSILICATE CLAY
South Africa
Event: PAMES
2015
Help poor families to have incomes from forest resources by valorisation of Toxic fungi and improve of sustainability development culture among North West Tunisian Family inhabitants.
Alexendria, Egypt
Event: TWAS-ARO "Green Economy: A Road Map for Sustainable Development and Poverty Reduction in the Arab Region"
2013
Ability of Lactobacillus plantarum MON03 to mitigate/counteract AFB1 and AFM1 in vitro and in vivo
Buenos Aires, Argentine
Event: 13th conference/24ème annual meeting of "the Academy of Sciences for the developing countries (TWAS)" .