Member Profile
Ila Jasra
Country of origin: India Currently in: United States, Covington, Kentucky General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2019 Doctorate Medical and Health Sciences incl Neurosciences -
Current Research Activities
Structural, Cell and Molecular Biology
My research focuses on the development of stem-cell-based therapies, with particular emphasis on the derivation and differentiation of induced pluripotent stem cells (iPSCs). My work encompasses generating iPSC-derived organoids and functional cell types for disease modeling and therapeutic interventions. In my current role at Cincinnati Children's Hospital Medical Center, I am spearheading projects to differentiate human iPSCs into intestinal organoids and pancreatic islet cells, optimizing 3D culture systems and bioreactor-based processes. These innovations aim to advance treatments for diabetes and gastrointestinal diseases. Previously, at the Alberta Diabetes Institute (ADI) Canada, I have developed methods for scaling up the differentiation of iPSCs into pancreatic islet cells in 3D bioreactors for therapeutic use. My work has included cutting-edge CRISPR-Cas9 genome editing to engineer iPSCs and optimize their differentiation into functional cell types. Additionally, I have extensive experience in isolating and characterizing stem cells, including mesenchymal, hematopoietic, and endothelial progenitor cells.
Publications resulting from Research:
Characterization of stem-cell-derived islets during differentiation and after implantation N. Cuesta-Gomez, K. Verhoeff, I.T. Jasra, R. Pawlick, N. Dadheech, et al. (2022)
Suspension culture improves iPSC expansion and pluripotency phenotype N. Cuesta-Gomez, K. Verhoeff, N. Dadheech, T. Dang, I.T. Jasra, M.B. de Leon, et al. (2023)
Optimizing generation of stem cell-derived islet cells K. Verhoeff, N. Cuesta-Gomez, I. Jasra, B. Marfil-Garza, N. Dadheech, et al. (2022)
Stem Cell–Derived Islet Transplantation in Patients with Type 2 Diabetes: Can Diabetes Subtypes Guide Implementation? K. Verhoeff, B.A. Marfil-Garza, Z. Czarnecka, N. Cuesta-Gomez, I.T. Jasra, et al. (2023)
Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation I.T. Jasra, N. Cuesta-Gomez, K. Verhoeff, B.A. Marfil-Garza, N. Dadheech, et al. (2023)
Opportunities and impediments to delivery of autologous human iPSC-islets in the curative treatment of type-1 diabetes N. Dadheech, N. Cuesta-Gomez, I.T. Jasra, K. Verhoeff, B. Marfil-Garza, et al. (2022)
Evaluating the potential for ABO-incompatible islet transplantation: expression of ABH antigens on human pancreatic, isolated islets, and embryonic stem cell-derived islets K. Verhoeff, N. Cuesta-Gomez, Ila Jasra, P. Albers, R. Pawlick, B.A. Marfil-Garza, et al. (2023)
Complete Suspension Differentiation of Human Pluripotent Stem Cells into Pancreatic Islets Using Vertical Wheel® Bioreactors N. Dadheech, M. Bermúdez de León, N. Cuesta-Gomez, I.T. Jasra, et al. (2023)
Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell–Based Islet Cell Transplant K. Verhoeff, B.A. Marfil-Garza, N. Cuesta-Gomez, I. Jasra, N. Dadheech, et al. (2022)
Towards Early Prediction of Human iPSC Reprogramming Success A. Singh, I.T. Jasra, O. Mouhammed, N. Dadheech, N. Ray, J. Shapiro (2023)
Correction: Optimizing Generation of Stem Cell-Derived Islet Cells K. Verhoeff, N. Cuesta-Gomez, I. Jasra, B. Marfil-Garza, N. Dadheech, et al. (2023)
Current profession
Current professional activities type:ResearchIn my current role at Cincinnati Children's Hospital Medical Center, I am spearheading projects to differentiate human iPSCs into intestinal organoids and pancreatic islet cells, optimizing 3D culture systems and bioreactor-based processes. These innovations aim to advance treatments for diabetes and gastrointestinal diseases.
Workshop and Conference Attended
2024 Hamburg ISSCR Stem Cell conferenceAffiliations
ATMP sweden
