Member Profile
Membership type: full
Nirmani Yasara Jayawickrama Wijethunga
Country of origin: Sri Lanka Currently in: Sri Lanka, Galle General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2022 Doctorate Medical and Health Sciences incl Neurosciences2017 Master Structural, Cell and Molecular Biology -
Current Research Activities
Medical and Health Sciences incl Neurosciences
Publications resulting from Research:
01-Article
Fejzo M , Rocha N , Cimino I , Lockhart S, Petry C, Kay R,Burling K, Barker P, George A, Yasara N et al.,
GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature (2023).
https://doi.org/10.1038/s41586-023-06921-9
02-Article
Badat M, Ejaz A, Hua P, Rice S, Zhang W, Hentges L, Fisher C, Denny N, Schwessinger R, Yasara N, Roy N,
Issa F , Roy A, Telfer P , Hughes J, Mettananda S, Higgs D and Davies J
Direct correction of haemoglobin E/β- thalassaemia using base editors. Nature communication 19;14(1):2238
https://doi.org/10.1038/s41467-023-37604-8
03- Article
Karusheva Y, Petry CJ, Yasara N, Kottahachchi D, Premawardhena A, Barker P, Burling K, Sattar N, Welsh P, Mettananda S, O'Rahilly S
Association of GDF15 levels with body mass index and endocrine status in β‐thalassaemia. Clinical Endocrinology, 99: 182-189 (2023),
https://doi.org/10.1111/cen.14897
04-Article
Yasara N, Wickramarathne N, Mettananda C, Silva I, Hameed N, Attanayaka K, Rodrigo R, Wickramasinghe N, Perera L, Manamperi A, Premawardhena A, Mettananda S
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion- dependent β- thalassaemia. Scientific Reports 12(1), 2752 (2022).
https://doi.org/10.1038/s41598-022-06774-8
05-Article
Yasara N, Premawardhena A, Mettanand S.
A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic Orphanet Journal of Rare Disease, 16(1),114 (2021)
https://doi.org/10.1186/s13023-021-01757-w
06- Article
Mettananda S, Yasara N, Fisher C.A, Taylor S, Gibbons R, Higgs D. Synergistic silencing of α-globin and
induction of γ-globin by histone deacetylase inhibitor,
vorinostat as a potential therapy for β-thalassaemia Scientific Reports, 9(1), 11649 (2019)
https://doi:10.1038/s41598-019-48204-2
07- Article
Yasara N, Wickramarathne N, Mettananda C, Manamperi A, Premawardhena A, Mettanand S.
Efficacy and safety of oral hydroxyurea in transfusion dependent beta-thalassaemia: a protocol for randomized double-blind controlled clinical trial,BMJ open 2020 e041958
https://doi:10.1136/bmjopen-2020-041958
08- Article
Rathnasiri A, Rathnayaka H, Yasara N, Mettananda S
Electronic screen device usage and screen time among preschool children in a suburban area of Sri Lanka, BMC
pediatrics, 22(1),390(2022)
https://doi.org/10.1186/s12887-022-03452-6
09- Preprint
Fejzo M , Rocha N , Cimino I , Lockhart S, Petry C, Kay R, Burling K, Barker P, George A, Yasara N et al.,
Fetally encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy
[Preprint]. doi:10.1101/2023.06.02.542661.
10- Book Chapter
Yasara J.W.N and Mettananda S.
Genetic modifiers of β-thalassemia and their therapeutic implications
Book title: Fetal Hemoglobin: The Panacea for Major β-
Hemoglobinopathies Publisher: Nova Science Publishers,
New York, USA (ISBN: 978-1-53617-955-2)
Current profession
Current professional activities type:Teaching
Affiliations
SLAAS -
Other Awards
May 2022Senate honoursSenate honours for conducting high-quality research and publishing in the year 2022 in international indexed journal- University of Kelaniya Sri LankaMay 2021Senate honoursSenate honours for conducting high-quality research and publishing in the year 2021 in international indexed journal- University of Kelaniya Sri LankaAug 2020Senate honoursSenate honours for conducting high-quality research and publishing in the year 2020 in international indexed journal- University of Kelaniya Sri LankaMay 2017Best oral presentationBest oral presentation for Anti-Oxidant and Anti-proliferative activity of Triphala at 10th International Research Conference at General Sir John Kotelawala Defense University, Sri Lanka
