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Membership type: full

Bensu Karahalil

Country of origin: Turkey Currently in: Turkey, ankara General field of specialization: Biological Systems and Organisms
Academic Background

Degrees

2005 Doctorate Biological Systems and Organisms
Research and Profession

Current Research Activities

Biological Systems and Organisms

Toxicology Risk assessment Ocuupational and environmental toxicology Cosmetic toxicology

Research Keywords: 
toxicology

Publications resulting from Research: 


1. Şardaş, S., Karahalil, B., Karakaya, A.E., Şaşmaz, R.: Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and longwave radiation, Mutation Res., 312, 79-83, 1994.
2. Şardaş, S., Karahalil, B., Akyol, D., Kükner, S., Karakaya, A.E.: The effect of smoking SCE rate of newborn to smoking mothers, Mutation Res., 341, 249-253, 1995.
3. Karakaya, A.E., Karahalil, B., Yılmazer, M., Aygün, N., Şardaş,S., Burgaz,S.: Evaluation of genotoxic potential of styrene in furniture workers using unsaturated polyester resins, Mutation Res., 392, 261-268, 1997.
4. Şentürker, S., Karahalil, B., İnal, M., Yılmaz, H., Müslümanoğlu, H., Gedikoğlu, G., Dizdaroğlu, M.: Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia, FEBS Letters, 416, 286-290, 1997.
5.Karahalil, B., Roldan-Arjona, T., Dizdaroğlu, M.: Substrate specificity of Schizosaccharomyces pombe Nth protein for products of oxidative DNA damage, Biochemistry, 37, 590-595, 1998.
6. Karahalil, B., Girard, P., Boiteux, S., Dizdaroğlu, M.: Substrate specificity of the Ogg 1 protein of Saccharomyces cerevisiae: Excision of guanine lesions produced in DNA by ionizing radiation- or metal ion/hydrogen peroxyde-generated free radicals, Nucleic acid Res., 26, 1228-1232, 1998.
7. Karahalil, B., Burgaz, S., Fişek, G., Karakaya, A.E.: Biological monitoring of young workers exposed to polycyclic aromatic hydrocarbons in engine repair workshops, Mutation Res., 412, 261-269,1998.
8. Burgaz, S., Erdem, O., Karahalil, B., Karakaya, A.E: Cytogenetic biomonitoring of workers exposed to bitumen fumes; Mutation Res., 419, 123-130, 1998.
9. Dizdaroğlu, M., Karahalil, B., Şentürker, S., Buckley, T.S., Roldan-Arjona, T.: Excision of products of oxidative DNA base damage by human NTH 1 protein, Biochemistry, 38,243-246, 1998.
10.Burgaz, S., Karahalil, B., Bayrak, P., Taşkın, L., Yavuzaslan, F., Bökesoy, I., Anzion, R.P.M., Bos, R.P.,Platin, N.: Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and in exfoliated buccal epithelial cells of nurses handling antineoplastics, Mutation Res., 439, 97-104,1999.
11. Karahalil, B., Karakaya, A.E., Burgaz., S.: The micronucleus assay in exfoliated buccal cells: application to occupational exposure to polycyclic aromatic hydrocarbons, Mutation Res., 442, 29-35, 1999.
12. Kocabaş, N. A., Karahalil, B., Karakaya, A. E., Şardaş, S.: Influence of GSTM1 genotype on comet assay and chromosome aberrations after induction by bleomycin in cultured human lymphocytes, Mutation Res., 469, 199-205, 2000.
13. Burgaz, S., Karahalil, B., Canlı, Z., Terzioglu, F., Ançel, G., Anzion, R.B.M., Bos, R.P., Hüttner, E.: Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations, Hum. Exp. Toxicol., 21,129-135, 2000.
14. Karahalil B., Şardaş S., Kocabaş N.A., Alhayıroğlu E., Karakaya, A.E., Civelek, E.: Chromosomal aberrations under basal conditions and after treatment with X-ray in human lymphocytes as related to the GSTM1 genotype, Mutation Res., 515, 135-140, 2002.
15. Burgaz, S., Demircigil, G.C., Karahalil, B., Karakaya, A.E.: Chromosomal damage in peripheral blood lymphocytes of traffic policemen and taxi drivers exposed to urban air pollution, Chemosphere, 47, 57-64, 2002.
16. Karahalil, B., Hogue, B.A., de Souza-Pinto, N.C., Bohr, V. A.: Base excision repair capacity in mitochondria and nuclei: tissue-specific variations, FASEB J., 16,1895-11902, 2002.
17. Biri, A., Civelek, E., Karahalil, B., Sardas, S.: Assessment of DNA damage in woman using oral contraceptives, Mutation Res., 521, 113-119, 2002.
18. Jensen, A., Calvayrac, G., Karahalil, B., Bohr, V.A., Stevnsner, T.: Mammalian OGG1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei, J Biol. Chem. 278, 19541-8, 2003.
19.Karahalil, B., Souza-Pinto, N., Parsons, J.L., Elder, .H., Bohr,V.: Compromised incision of oxidised pyrimidine in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases, J Biol. Chem., 278, 33701-33707, 2003.
20. Stuart, J., Karahalil, B., Barbara, H., Souza-Pinto, N., Bohr, V.: Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction, FASEB J, 18, 595-597, 2004.
21. Karahalil, B., Yağar, S.,Bahadır, G.,Şardaş, S.: Evaluation of genotoxic effects of Diazepam and Propofol by Chromosomal Aberration Assay in Cardiac Patients, Mutation Res., 581, 181-186, 2005.
22. Karahalil, B, Aygün Kocabaş, N.: hOGG1 Ser326Cys genetic polymorphism in a Turkish population. Arch Toxicol, 79, 377-380, 2005.
23 İmam, Z.S, Karahalil, B., Hogue, B.A., Souza-Pinto, N.C., Bohr, V.A.: Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging, 27,1129-1136, 2006.
24. Karahalil, B., Rahravi, H., Ertaş, N., Karakaya, A.E.: Examination of urinary mercury levels in dentists using cold-vapour atomic absorption spectrometry and mercury toxicity, Hum. Exp. Toxicol. 24, 383-388, 2005.
25. Kocabaş N.A., Karahalil, B.: XRCC1 Arg399Gln Genetic Polymorphism in a Turkish Population. Int. Toxicol., 25, 419-422, 2006.
26. Karahalil, B., Kocabaş, NA, Özçelik, T.: DNA Repair Gene Polymorphisms and Bladder Cancer Susceptibility in a Turkish Population, Anticancer Res., 26, 4955-4958, 2006.
27. Karahalil, B., Yağar, S., Özin, Y.: Release of α-glutathione s-transferase (α-GST) and hepatocellular damage induced by Helicobacter pylori and eradication treatment, Curr. Drug Safety, 2, 43-46, 2006.
28. Karahalil, B., Aykanat, B., Ertaş, N.: Dental lead levels in children from two different urban and suburban areas of Turkey. Int. J Hyg. Environ. Health 210, 107-12, 2007.
29. Kaymak C, Karahalil B, Ozcan NN, Oztuna D. Association between GSTP1 gene polymorphism and serum alpha-GST concentrations undergoing sevoflurane anaesthesia, Eur J Anaesthesiol.,25, 193-199, 2008.
30. Karahalil B, Emerce E, Koçer B, Han S, Alkiş N, Karakaya AE. The association of OGG1 Ser326Cys polymorphism and urinary 8-OHdG levels with lung cancer susceptibility: a hospital-based case-control study in Turkey. Arh Hig Rada Toksikol., 59:241-250, 2008.
31. Karahalil B, Coskun E, Emerce E., ADRA2A polymorphism and smoking in a Turkish population. TIH, 24, 171-176, 2008.
32. Au WW, Sardas S, Karakaya AE, Karahalil B: Vth International Conference on Environmental Mutagens in Human Populations: introduction. Mutation Res., 659, 2-3, 2008.
33. Karahalil B, Gumus T, Emerce E, Izdes S, Kanbak O, Kesimci E. Comet assay in evaluating DNA damage associated with ischaemia-reperfusion injury in patients undergoing coronary surgery. Arh Hig Rada Toksikol., 60,307-315, 2009.
34. Karahalil B, Emerce E, Kocabas NA, Akkas E, Associations between GSTM1 and OGG1 Ser326Cys polymorphisms and smoking on chromosomal damage and birth growth in mothers. Mol Biol Rep., 38:2911-2918, 2011.
35.Karahalil B, Polat S, Senkoylu A, Bölükbaşı S. Evaluation of DNA damage after tourniquet-induced ischaemia/reperfusion injury during lower extremity surgery, Injury, 41:1003-1007, 2010.
36. Engin AB, Karahalil B, Engin A, Karakaya AE. Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma. Genet Test Mol Biomarkers, 14, 559-564, 2010.
37. Türkan H, Aydin A, Sayal A, Karahalil B.: The Effect of Sevoflurane and Desflurane on Markers of Oxidative Status in Erythrocyte, TIH, 27:181-186, 2011.
38. Yağar S, Yavaş S, Karahalil B.: The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep. 38:3383-3389, 2011.
39. Karahalil B, Kesimci E, Emerce E, Gumus T, Kanbak O.: The impact of OGG1, MTH1 and MnSOD gene polymorphisms on 8-hydroxy-2'-deoxyguanosine and cellular superoxide dismutase activity in myocardial ischemia-reperfusion. Mol Biol Rep. 38:2427-2435, 2011.
40. Karahalil B., Bohr VA, De Souza-Pinto, NC.: Base Excision Repair Activities Vary in Human Lung Cancer Cells and Corresponding Normal Controls, Anticancer Res., 30:4963-4971, 2010.
41. Engin AB, Karahalil B, Engin A, Karakaya AE. DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma. Mol Biol Rep., 38:5379-5386, 2011.
42. Dhawan A, Shanker R, Laffon B, Tajes JF, Fuchs D, van der Laan G, van Broekhuizen P, Becker H, Moriske HJ, Teixeira JP, Carriere M, Herlin-Boime N, Engin AB, Coskun E, Karahalil B. NanoLINEN: nanotoxicology link between India and European Nations. J Biomed Nanotechnol., 7:203-204, 2011.
43. Türkan H, Aydin A, Sayal A, Eken A, Akay C, Karahalil B. Oxidative and antioxidative effects of desflurane and sevoflurane on rat tissue in vivo. Arh Hig Rada Toksikol., 62:113-119, 2011.
44. Gopalan RC, Emerce E, Wright CW, Karahalil B, Karakaya AE, Anderson D. Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay. Toxicol Lett., 207:322-325, 2011.
45.Engin AB, Karahalil B, Karakaya AE, Engin A. Association between XRCC1 Arg399Gln and P53 Arg72Pro polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol., 62:207-214, 2011.
46. Karahalil B, Ulukaya M, Alp O. Pilot Study of Environmental Monitoring of Konya Region near Abandoned Mercury Mine in Turkey. Bull Environ Contam Toxicol. 88:150-153, 2012.
47. Kesimci E, Engin AB, Kanbak O, Karahalil B. Association between ABCB1 gene polymorphisms and fentanyl's adverse effects in Turkish patients undergoing spinal anesthesia. Gene. 493:273-277, 2012.
48. Gönül N, Kadioglu E, Kocabaş NA, Ozkaya M, Karakaya AE, Karahalil B. The role of GSTM1, GSTT1, GSTP1 and OGG1 polymorphisms in type 2 diabetes mellitus risk: A case-control study in a Turkish population. Gene 505:121-127, 2012.
49. Karahalil B., Engin AB., Coşkun E.: Could OGG1 enzyme polymorphism be a biomarker of susceptibility in cancer? Review, TIH, 30, 814-825, 2012.
50. Engin AB, Doruk E, Karahalil B.: Effect of N-acetyl cysteine, Neopterin and Dexamethasone on the Viability of Titanium dioxide Nanoparticles Exposed Cell Lines, Pteridines, 23(4),111-122, 2012.
51. Karahalil B., Bohr VA., WilsonIII DM.: Impact of DNA Polymorphisms in Key DNA Base Excision Repair Proteins on Cancer Risk. Review Article, HET, 31: 981-1005, 2012.
52. Kadioglu E., Kocabaş NA., Demircigil GD., Coskun E., Ozcagli E. Durmaz E., Karahalil B., Burgaz S., Sardas S.: Assessment of Individual Susceptibility to Baseline DNA and Cytogenetic Damage in a Healthy Turkish Population: Evaluation with Lifestyle Factors, Genetic Testing and Molecular Biomarkers, 16, 1157-1161, 2012.
53. Cinar O, Dilbaz S, Terzioglu F, Karahalil B, Yücel C, Turk R, Taskin L, Kose SK. Does cigarette smoking really have detrimental effects on outcomes of IVF? Eur J Obstet Gynecol Reprod Biol. Eur J Obstet Gynecol Reprod Biol. 2014 Mar;174:106-10.
54. Karahalil B, Kadioglu E, Tuzuner-Oncul AM, Cimen E, Emerce E, Kisnisci RS. Micronucleus assay assessment of possible genotoxic effects in patients treated with titanium alloy endosseous implants or miniplates. Mutat Res. 760:70-2, 2014.
55.Karahalil B. Melamine toxicity and safety issue in infant Formula, Journal of Translational Toxicology, 1, 2014, 72-75.
56. Karahalil B, Orhan G, Ak F. The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis.Clin Neurol Neurosurg.;139:288-94, 2015.
57. Braz MG, Karahalil B. Genotoxicity of Anesthetics Evaluated In Vivo (Animals). Review.Biomed Res Int., 2015:1-8, 2015.
58.Engin AB, Karahalil B, Karakaya AE, Engin A. Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer.World J Gastroenterol.21(12):3636-43, 2015.
59.Orhan G, Eruyar E, Mungan SÖ, Ak F, Karahalil B. The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis. Clin Neurol Neurosurg. 2016; 146:96-101.
60. Orhan G, Elkama A, Mungan SÖ, Eruyar E, Karahalil B. The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke. Neurol Sci. 2016 ;37(6):955-61.
61. Ciba M, Ak M, Karahalil B.: Alpha-glutathione-s-transferase can be biomarker for both drug-related toxicity as well as individual susceptibility, Minerva Psichiatrica, 2016, 57, 61-72.
62. Terzioğlu F, Karahalil B, Yücel Ç, Türk R. The effect of cotinine concentrations in seminal plasma and follicular fluid on the pregnancy outcomes of couples undergoing assisted reproductive techniques. Turk J Med Sci. 2016, 17;46(5):1495-1501.
63. Karahalil B. Overview of Systems Biology and Omics Technologies. Curr Med Chem. 2016;23(37):4221-4230.
64. Terzioglu F, Turk R, Yucel C, Dilbaz S, Cinar O, Karahalil B. The effect of anxiety and depression scores of couples who underwent assisted reproductive techniques on the pregnancy outcomes. Afr Health Sci. 2016;16(2):441-50.
65. Karahalil B, Elkama A, Orhan G. Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke. J Gene Med. 2017;19(3).
66. Kesimci E, Çoşkun E, Uğur G, Müderris T, İzdeş S, Karahalil B. Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients? Turk J Anaesthesiol Reanim. 2017;45(5):264-269.
67. Karahalil B, Hare E, Koç G, Uslu İ, Şentürk K, Özkan Y. Hepatotoxicity associated with statins. Arh Hig Rada Toksikol. 2017 Dec 20;68(4):254-260.
68. Salihoğlu E, Demokan S, Karanlık H, Karahalil B, Önder S, AkaydınS.; Investigation of expression levels of DNA repair genes in molecular subtypes of breast cancer, J Proteomics Bioinform, 10 (12) 2017.
69. Elkama A, Karahalil B. Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis. Arh Hig Rada Toksikol. 2018 Mar 1;69(1):25-31.


BOOK CHAPTERS
1.Karahalil B.: Benefits and risks of phytoestrogens (Ed. Yıldız, F., Adlercreutz, H.) Phytoestrogens in Functional Foods, Taylor & Francis. CRC Press, New York, NY, 2006.

2.Karahalil B.: Advances in Food Biochemistry (Ed. Fatih Yıldız) Pharmacogenomics and Toxicogenomics in Food Chemicals, Taylor&Francis, CRC Press., 2010.

3. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management (Eds.Vineet Kumar, Nandita Dasgupta, Shivendu Ranjan) March 26, 2018 by CRC Press, ISBN 9781498799416 - CAT# K30584, Karahalil B., Chapter: Challenges, Recommendations, and Strategies for Nanotoxicology Evaluation and Its Management


INTERNATIONAL CONGRESSES
1. Şardaş, S., Karakaya, A.E., Gök, S., Karahalil, B.: Genotoxic risk in the hospital environment. 50th International Congresses of FIP, September 3-7, Abst. P 11, İstanbul, Turkey, 1990.

2. Şardaş, S., Karakaya, A.E., Karahalil, B.: Sister chromatid exchange in nurses and anesthesilogist, International Congress of the European Association of Poising Control Centers, September 25-29, Abst. P 87, Milano, Italy, 1990.

3. Şardaş, S., Karahalil, B., Karakaya, A.E., Şaşmaz, R.: Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and longwave ultraviolet radiation, 3rd International Symposium on Pharmaceutical Sciences, Ankara University, Faculty of Pharmacy, June 15-18, Abst. P 98, Ankara, Turkey, 1993.

4. Şardaş, S., Karahalil, B., Ada, M., Karakaya, A.E., Aydın, N,. Şaşmaz, R.: Evaluation of genotoxicity in patients under antiepileptic and PUVA treatment, 50th European ISSX Meeting, September, 26-29, Abst. P 162, Tours, France, 1993.

5. Karahalil, B., Şardaş, S., Akyol, D., Kükner, S., Karakaya, A.E.: The effect of smoking on SCE rate of newborn infants born to smoking mothers, 1st International Meeting on Pharmacy and Pharmaceutical Sciences, September 4-7, Abst. P 145, İstanbul, Turkey, 1994.

6. Karakaya, A.E., Şardaş, S., Karahalil, B., Akyol, D.: The effect of smoking on SCE rate of newborn infants born to smoking mothers. The International Toxicologist "Horizons in Toxicology: Preparing for the 21st Century" July 2-6, 1995 Abst. 46- P-8, Washington, USA.

7. Burgaz, S., Karahalil, B., Yılmazer, M., Aygün, N., Şardaş, S., Karakaya, A.E.: Evaluation of genotoxic risk for styrene exposed workers, 2nd International Conference on Environmental Mutagens in Human Populations, August, 20-25, 1995, Abst. P4-4, Praque, Czech Republic.

8. Burgaz, S., Karahalil, B., Yılmazer, M., Aygün, N., Şardaş, S., Karakaya, A.E.: Evaluation of genotoxic risk for styrene exposed workers, Abstracts of the Biennial Meeting of the World Institute of Ecology and Cancer and the European Institute of Ecology and Cancer (WIEC-INEC), Journal of Environmental Pathology, Toxicology and Oncology, Vol. 14, No.3-4, Abst. P 241, October 6-8, Bursa, Turkey, 1995.

9. Roldan-Arjona, T., Karahalil, B., Wei, F., Carter, K., Kungland, A., Dizdaroğlu, M., Lindahl, T.: Eukaryotic DNA glycosylases that repair oxidative DNA damage, DNA Repair and Genome Instability Workshop, June 9-11, Abst.P 72, Madrid, Spain, 1997.

10. Karakaya, A.E., Karahalil, B., Fişek, G., Burgaz, S.: Biological monitoring of young workers exposed to polycyclic aromatic hydrocarbons ine engine repair workshops, EUROTOX’97, June 25-28, Abst. P 6-18, Aarhus, Denmark, 1997.

11. Roldan-Arjona, T., Karahalil, B., Dizdaroğlu, M.: Substrate specificity of eukaryotic NTH homologues. NATO-Advanced Study Instıtute on “DNA Damage and Repair”, October 14-24, ,Abst. P 25, Antalya, Turkey, 1997.

12. Şentürker, S., Karahalil, B., İnal, M., Yılmaz, H., Müslümanoğlu, H., Gedikoğlu, G., Dizdaroğlu, M.: Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia. NATO-Advanced Study Instıtute on “DNA Damage and Repair”, October 14-24, Abst. P11, Antalya, Turkey,1997.

13. Karahalil, B., Burgaz, S., Erdem., O., Karakaya, A.E.: Cytogenetic biomonitoring of workers exposed to bitumen fumes, International Congress of Toxicology ICT VIII, July 5-10, Abst. P1A25, Paris, France, 1998.

14. Karahalil, B., Erdem, O., Burgaz, S., Karakaya, A.E.; Biological monitoring of polycyclic aromatic hydrocarbons by genotoxicity endpoints and chemical procedures in exposed workers, SecoTox 98, October 19-21, Abst. P 225, Antalya, Turkey, 1998. (Sözlü Bildiri) .

15. Karahalil, B., Canlı, Z., Ançel, G., Terzioğlu, F., Anzion, R.B.M., Bos, R.P., Hüttner, E., Burgaz, S.: Urinary cyclophosphamide excretionnand chromosomal aberrations in perpheral lymphocytes of nurses after occupational exposure to antineoplastic agents, NATO-Advanced Study Institute on “Human Monitoring after Environmental and Occupational Exposure to Chemical and Physical Agents” , September 23-October 3, Abst. P 15, Tekirova, Antalya, Turkey, 1999.

16. Karahalil, B., Burgaz, S., Karakaya, A.E.: The micronucleus assay in exfoliated buccal cells: Application to occupational exposure to polycyclic aromatic hydrocarbons, The 4 th Congress of Toxicology in Developing Countries, November 6-10, Abst. P048, Antalya, Turkey, 1999.

17. Karahalil, B., Kocabaş, A.N., Karakaya, A. E., Şardaş, S.: Influence of GSTM1 genotype on comet assay and chromosome aberrations after induction by bleomycin in cultured human lymphocytes, 4th Congress of Toxicology in Developing Countries, November 6-10, Abst. P154, Antalya, Turkey, 1999.

18. Çakmak, G., Karahalil, B., Karakaya, A. E., Burgaz, S.: Exposure of traffic policemen and taxi drivers to urban air pollutants as measured by cytokinesis-blocked micronucleus technique in lymphocytes, 4th Congress of Toxicology in Developing Countries, November 6-10, Abst. P 049, Antalya, Turkey, 1999.

19. Karahalil, B., Kocabaş, N.A., Karakaya, A.E., Şardaş, S.: Influence of GSTM1 genotype on comet assay and chromosome aberrations after induction by bleomycin in cultured human lymphocytes, The 4th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries, April 12-16, Abst. P009, Antalya, Turkey, 2000.

20. Çakmak, G., Karahalil, B., Karakaya, A.E., Burgaz, S.: Exposure traffic policemen and taxi drivers to urban air pollutants as measured by chromosomal aberration frequencies in peripheral lymphocytes, The 4th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries, April 12-16, Abst. P002, Antalya, Turkey, 2000.

21. Karahalil, B., Roldan-Arjona, T., Dizdaroğlu, M.: Substrate specificity of Schizosaccharomyces pompe Nth protein for products of oxidative DNA damage, The 6th International Symposium on Pharmaceutical Sciences (ISOP-6), June 27-29, Abst. P-179, Ankara, Turkey, 2000.

22. Çakmak, G., Karahalil, B., Karakaya, A.E., Burgaz, S.: Exposure of traffic policemen and taxi drivers to urban air pollutants as measured by cytogenetic effects in lymphocytes, The 6th International Symposium on Pharmaceutical Sciences (ISOP-6), June 27-29, Abst. P-171, Ankara, Turkey, 2000.

23. Burgaz, S., Çakmak, G., Karahalil, B., Karakaya, A.E.: Exposure of traffic policemen and taxi drivers to urban air pollutants as measured by cytogenetic effects in lymphocytes, Toxicology Letters, EUROTOX’2000, September 17-20, Abst. 268, London, England, 2000.

24. Karakaya, A.E., Kocabaş, N.A., Karahalil, B., Şardaş, S.: Relationship between the GSTM1 genetic polymorphism and genotoxicity tests (Comet Assay and Chromosome Aberration) induced by bleomycin in human lymphocytes, Toxicology Letters, EUROTOX’2000, September 17-20, Abst. 272, London, England, 2000.

25. Karahalil, B., Canlı, Z., Ançel, G., Terzioğlu, F, Anzion, R.B.M., Hüttner, E., Burgaz, S.: Urinary cyclophoshamide excretion and chromosomal aberrations in peripheral lymphocytes of nurses after occupational exposure to antineoplastic agents, Toxicology Letters, EUROTOX’2000, September 17-20, Abst. 271, London, England, 2000.

26. Demiroğlu, C., Demircigil, Ç.G., Durmaz, E., Karahalil, B., Akaydın,S., Torun,M., Burgaz,S.: Analysis of cytokinesis-block micronuclei and antioxidant status in nurses handling antineoplastic drugs, Toxicology Letters, EUROTOX 2001, September 13-16, Vol.123, Suppl1,p.120, İstanbul, Turkey, 2001.

27. Durmaz, E., Demircigil, Ç.G., Demiroğlu, C., Karahalil,B., Akaydın,S., Torun,M., Burgaz,S.: Analysis of chromosomal aberrations and plasma antioxidant levels in oncology nurses,Toxicology Letters, EUROTOX 2001, September 13-16, Vol.123, Suppl1,p.121, İstanbul,Turkey, 2001.
28. Karahalil, B., Kocabas, N.A., Civelek, E., Karakaya, A.E., Sardas,S.: The Evaluation of Relation to GSTM1 Genetic Polymorphism and Chromosomal Aberrations and Challenge Assay. EUROTOX-2001, September 13-16, Istanbul, Turkey, 2001.

29. Karahalil, B., Souza-Pinto, N., Bohr. V.: Comparison of base excision repair activities in nucleus and mitochondria from various mouse tissues, American Association for Cancer Research (AACR), 93rd Annual Meeting, April 6-10, Abst. 3116A, San Francisco, California, 2002.

30. Stuart, J. A., Souza-Pinto, N.C., Karahalil, B., Stevnsner, T., Hogue, B.A., Bohr, V.A.: Importance of mitochondrial oxoguanine DNA glycosylase (Ogg1) in the repair of mtDNA oxidative damage, Keystone Symposia, Abst.133, April 6-11, Colorado, USA, 2002.

31. Karahalil, B., Souza-Pinto, N., Bohr, V.A.: DNA repair processes in mouse and human mitochondria, NIH Retreat Meeting, March 19-21, Baltimore, USA, 2002.

32. Souza-Pinto, N.C., Karahalil, B., Elder, R.H., Bohr, V.A.: DNA repair activities in mitochondria from mice deficient in two major oxidative damage DNA glycosylases, OGG1 and NTH1. 8th Annual NIA Intramural Retreat, March 26-28, Baltimore, USA, 2003.

33. Imam, S.Z., Karahalil, B., Dizdaroglu, M., May, A., Souza-Pinto, N.C., Bohr, V.A.: Oxidative markers of DNA damage in brain regions: Implications in aging and neurodegenaration, 8th Annual NIA Intramural Retreat, March 26-28, Baltimore, USA, 2003.

34. Stuart, J.A., Karahalil, B., Hogue.B., Souza-Pinto, N.C., Bohr, V.A.: Nuclear and mitochondrial base excision repair in a caloric restriction model of life span extention, Eighth Annual NIA Intramural Retreat, March 26-28, Baltimore, USA, 2003.

35. Karahalil, B.: Biomonitoring of drug-induced DNA damage by Sister Chromatid Exchange and Micronucleus, Al-Azhar 3rd International Conference for Pharmaceutical&Biological Sciences, p.11, December 16-18, 2003, Cairo, Egypt (Sözlü Bildiri)

36. Durmaz, E., Karahalil, B.: Determination of acetominophen-induced oxidative damage by gas chromatograpy-isotope dilution mass spectrometry, 7th International Symposium on Pharmaceutical Sciences, Ankara-Turkey, P-204, 2003.

37. Civelek, E., Şardaş, S., Karahalil, B., Biri, A.: Assessment of DNA damage in women using oral contraseptives, 5th International Congress of Turkish Society of Toxicology, Antalya-Turkey, P-057, 2003.

38. Civelek, E., Şardaş, S., Kocabaş, N.A., Karahalil, B., Alhayıroğlu, E., Karakaya, A.E.: Chromosomal aberrations under basal conditions and after treatment with x-ray in human lymphocytes, as related to the GSTM1 genotype, 5th International Congress of Turkish Society of Toxicology, Antalya-Turkey, P-058, 2003.

39. Durmaz, E., Akaydın, S., Karahalil, B., Demiroğlu, G., Çakmak, G.D., Torun, M., Burgaz, S.: Bieomycin-induced chromosomal aberrations and antioxidant status in oncology nurses and control subjects, 5th International Congress of Turkish Society of Toxicology, Antalya-Turkey, P-059, 2003.

40.Yağar, S., Şardaş, S., Bahadır, B., Karahalil, B.: Genotoxic effects of intravenous anesthetic agents in cardiac surgery, 5th International Congress of Turkish Society of Toxicology, Antalya-Turkey, P-068, 2003.

41. Karahalil, B., Hogue, B.A., De Souza-Pinto, N.C., Bohr, V.A.: Base excision repair capacity in mitochondrial and nuclei: tissue specific variations, 10th International Congress of Toxicology, July 11-15, p. 71, abst. 510, Tampere, Finland, 2004.

42. Kocabaş, N.A., Özçağlı, E., Çakmak, G.D., Coşkun, E., Kadıoğlu, E., Durmaz, E., Karahalil, B., Burgaz, S., Şardaş, S.: Effects of glutathione S-transferase (GST) polymorphisms o n chromosomal aberrations and micronucleus frequencies in a Turkish population.35th Annual Meeting of the European Environmental Mutagen Society, 3-7 July, Kos Island, Greece, P133, Abst. 128, 2005.

43. Karahalil, B., Souza-Pinto, N.C., Parsons, J.L., Elder, R.H., Bohr, V.A.: Compromised incision of oxidised pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases, 35th Annual Meeting of the European Environmental Mutagen Society, 3-7 July, Kos Island, Greece, P5, Abst. 62, 2005.
44. Karahalil, B., Kocabaş, NA.: hOGG1 ser326Cys genetic polymorphism in a Turkish population, Abstract P8-19, Toxiology Letters, Volume 158, Suppl. 1. EUROTOX-2005, September 11-14, Cracow, Poland, 2005.
45. Karahalil, B., Kocabaş, NA.: XRCC1 Arg399Gln genetic polymorphism in a Turkish population, 36th Annual Meeting of the European Environmental Mutagen Society, P119 July 2-6, Prag, Czech republic, 2006.
46. Emerce E, Karahalil B, Koçer B, Han S, Alkış N, Karakaya AE.: hOOG1 Ser326Cys polymorphism and lung cancer susceptibility in Turkish population, The 5th International Conference on Environmental Mutagens in Human Populations, May 20-24, P-50, Antalya, Turkey, 2007.
47. Engin AB, Karahalil B, Kurukahvecioğlu O, Karakaya AE.: Gastric carcinoma and oxidative stress: Implications of hOGG1 Ser326Cys, The 5th International Conference on Environmental Mutagens in Human Populations, May 20-24, P-51, Antalya, Turkey, 2007.

48. Emerce ET, Karahalil B, Akkaş E, Kocabaş NA., Effect of the GSTM1 polymorphism on the Relationship Between Maternal Exposure to Environmental Tobacco Smoke and Neonatal Birth Weight, 6th International Congress of Turkish Society of Toxicology, the theme of the meeting is “Chemical Safety and Toxicology”, 2-5 November 2006, Antalya, Turkey, page:187.

49. Emerce ET, Karahalil B, Koçer B, Han S, Alkış N, Karakaya AE., hOGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility in Turkish Population, 5th International Conference on Environmental Mutagens in Human Populations, 20-24 May 2007, Antalya, Turkey, page:73.

50. Karahalil B, Yıkan A, Emerce ET, Alkış N., Association of the OGG1 Ser326Cys polymorphism with gynecologic cancer risk, 11th International Congress of Toxicology, the theme of the meeting is “Toxicology: Discovery Serving Society”, 15-19 July 2007, Montreal, Canada, PM2.058.

51. Emerce ET, Karahalil B, Koçer B, Han S, Alkış N, Karakaya AE., hOGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility in Turkish Population, 44th Congress of the European Societies of Toxicology, the theme of the meeting is “Missing Links”, 7-10 October 2007, Amsterdam, The Netherlands, page: 174.

52. Karakaya AE, Karahalil B, Emerce-Tufan E, Kocer B, Han S, Alkis N., Association of the OGG1 Ser326Cys Polymorphism with Lung Cancer Risk In A Turkish Population, 47th Annual Meeting and ToxExpo, Society of Toxicology, the themes of the meeting are “Developmental Basis of Disease, Oxidative Signaling and Redox Biology, Nanotechnology, and Stem Cell Biology and Toxicology”, 16-20 March 2008, Seattle, America, No: 404.

53. Emerce-Tufan E, Karahalil B, Akkaş E, Kocabaş NA., Maternal Smoking Effects on Neonatal Birth Growth and Its Association with Maternal GSTM1 and OGG1 Polymorphisms, 3rd EACEH - Euro-Asian Conference on Hazardous Waste & Human Health, 27-30 March 2008, İstanbul, Turkey, p: 62.

54. Emerce-Tufan E, Karahalil B, Gumus T, Izdes S, Kanbak O, Kesimci E., The Effects of Ischemia/Reperfusion Injury on Lactate Levels and DNA Damage in Patients Undergoing Coronary Artery Bypass Graft Surgery, 38th Annual Meeting of Environmental Mutagen Society, the theme of the meeting is “Environmental Mutagens and Human Health”, 21 – 25 September 2008, Cavtat, Croatia, page: 127.

55. Emerce-Tufan E, Karahalil B, Coskun E., Alpha-2A Adrenergic Receptor Gene (ADRA2A) Polymorphism in Turkish Population, 45th Congress of the European Societies of Toxicology, the theme of the meeting is “From Toxins to Omics: Health, Safety and Well-being”, 5 - 8 October 2008, Rhodes, Greece, page:81.

56. Karahalil B, Emerce-Tufan E, Gumus T, Izdes S, Kanbak O, Kesimci E., The Alkaline Comet Assay as Biomarker in Assessment of DNA Damage After Ischemia-Reperfusion Injury in Patients Undergoing Coronary Surgery, 45th Congress of the European Societies of Toxicology, the theme of the meeting is “From Toxins to Omics: Health, Safety and Well-being”, 5 - 8 October 2008, Rhodes, Greece, page:83.

57. Emerce E, Karahalil B, Kesim E, Gümüş T, Kanbak O., Effect of the Individual Susceptibility on Oxidative Damage in Ischemia-Reperfusion Depending on Coronary Artery Bypass Graft Surgery, 7th Congress of the Society of Turkish Toxicology with International Attendance, the theme of the meeting is “Rational Usage of Toxicology in Protection of Human Health and Environment” 30 May – 1 June 2009, Ankara, Turkey, page: 87.

58. Emerce E, Karahalil B, Kesim E, Gümüş T, Kanbak O., Association of the OGG1 Ser326Cys Polymorphism with Oxidative DNA Damage in Myocardial Ischemia-Reperfusion, 9th International Symposium on Pharmaceutical Sciences, 23 – 26 June 2009, Ankara, Turkey, page: 398.

59. Emerce E, Karahalil B, Kesim E, Gümüş T, Kanbak O., The Roles of DNA Gene Polymorphisms and Antioxidant Activity in Ischemia – Reperfusion Status in Clinic, 10th International Conference on Environmental Mutagens, the theme of the meeting is “The Renaissance of Environmental Mutagenesis”, 20 – 25 August 2009, Florence, Italy, page: 254.

60. Scheibye-Knudsen, M., Keijzers, G., Karahalil, B., Bohr, VA.: Mitochondrial DNA repair in tissues from the CSB m/m mouse, Cockayne syndrome: molecular mechanisms and translational implications, Boston, September 12-15, 2009, Massachusetts, USA.

61. Karahalil B.: Application of Genomic Technologies to Toxicology, 7. Turkish Society of Toxicology Congress with International Participation: Rational use of toxicology Protection of Human Health and the Environment. 30 May-1 June 2009, Ankara, Turkey.

62. B. Karahalil, E. Kadioglu, A.M. Tuzuner-Oncul, E. Cimen, E. Emerce, R.S. Kisnisci.: Assessment of genotoxic effects in patients treated with titanium alloy endosseous implants or miniplates by micronucleus assay P202-021, XII. International Congres of Toxicology, Toxicology Letters 196S (2010), S37–S351, 19-23 July 2010, Barcelona-Spain.

63. Keçik MC, Karahalil B.: Antipsychotic induced hepatotoxicity - case reports, literature review, 8 Turkish Society of Toxicology Congress with International Participation, 15-18 November 2012, Antalya, Turkey.

64. Battal D, Karahalil B.: Why we need validation of bioanalytical methods in forensic and clinical toxicology? 8. Turkish Society of Toxicology Congress with International Participation, 15-18 November 2012, Antalya, Turkey.

65. Elkama A, Orhan G, Eruyar E, Karahalil B.: The impact of detoxifying gene polymorphisms on the risk of stroke. TURKHELTOX Toxicology Congress - 9th Congress of the Turkish Society of Toxicology with participation of the Hellenic Society of Toxicology, 21-24 Ekim 2015, Çeşme, İzmir.

66. Karahalil B, Orhan G, Ak F.: The impact of dexoifying and repair gene polymorphism and the levels of serum ROS in the susceptibility to multiple sclerosis a hospital based case control study. 31st of the european committee for treatment and research in multiple sclerosis ECTRIMS, 7-10 Ekim 2015, Barcelona, Spain.

67. Karahalil B.: Genetic polymorphisms can be prognostic and predictive biomarkers for cancer risk. GPSS-International Gazi Pharmacy Symposium Series, 12-15 Kasım 2015, Antalya, Turkey.

68. Salihoğlu E, Demokan S, Karanlık H, Karahalil B, Önder S, AkaydınS.; Investigation of expression levels of DNA repair genes in molecular subtypes of breast cancer, 9th World Biomarkers Congress and the 20th International Congress on Pharmaceutical Biotechnology, 7-9 July 2017, Madrid, Spain.

69. Aşcı AE, Elkama A, Karahalil B.: The role of folate dependent genetic susceptibility in the risk of Multiple Sclerosis. 2nd International GaziPharma Simposium Series, 11-13 Ekim2017, Ankara.

70. Evrim E, Orhan G, Elkama A, Karahalil B.: The role of manganese superoxide dismutase and glutathione peroxicdase gene polymorphisms in Parkinson’s disease. Society of Toxicology 56th Annual Meeting, 10-15 Mart 2017, Baltimore, Amerika.

71. Elkama A, Ak M, Nemutlu E, İlik N, Karahalil B.: Serum alpha-GST activity as an alternative biomarker in olanzapine induced hepatotoxicity under the impact of genetic polymorphism of GSTs. EUROTOX’2017, 10-13 Eylül 2017, Sevilla, İspanya.



Current profession

Current professional activities type: 
Higher Education Study
Teaching, Research and Administration all together