Member Profile
Membership type: full
Amina Khatun
Country of origin: Bangladesh Currently in: Bangladesh, Dhaka General field of specialization: Agricultural Sciences-
Degrees
2015 Doctorate Agricultural Sciences2009 Master Agricultural Sciences2008 Undergraduate Agricultural Sciences -
Current Research Activities
Agricultural Sciences
Research and Teaching
Publications resulting from Research:
Publications (selected):
1. Khatun A¶, Nazki S¶, Jeong CG, Gu S, Salam SU, Lee SI, Yang MS, Lim B, Kim KS, Kim BS, Lee KT, Park CK, Lee SM, and Kim WI. Effect of polymorphisms in porcine guanylate-binding proteins on host 2 resistance to PRRSV infection in experimentally challenged pigs. Vet Res, 2020, Feb 19;51(1):14. (¶Contributed equally).
2. Khatun A¶, Park SY¶, Shabir N, Nazki S, Kang AR, Jeong CG, Seo BJ, Yang MS, Kim BS, Seo YH and Kim WI. Evaluation of the inhibitory effects of (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one (DiNap), a natural product analog, on the replication of type 2 PRRSV in vitro and in vivo. Molecules, 2019, Feb 26. (¶Contributed equally).
3. Shabir N¶, Khatun A¶, Nazki S, Gu S, Lee SM, Yang MS, Kim BS and Kim WI. In vitro immune responses of porcine alveolar macrophages reflect host immune responses against porcine reproductive and respiratory syndrome viruses. BMC Vet Res, 2018, Dec 4;14(1):380. (¶Contributed equally).
4. Kim SC, Nazki S, Kwon S, Juhng JH, Mun KH, Jeon DY, Jeong CG, Khatun A, Kang SJ and Kim WI. The prevalence and genetic characteristics of porcine circovirus type 2 and 3 in Korea. BMC Vet Res, 2018, Sep 26; 14(1): 294.
5. An CH, Nazki S, Park SC, Jeong YJ, Park SJ, Khatun A, Kim WI, Park YI, Jeong JC and Kim CY. Plant synthetic GP4 and GP5 proteins from porcine reproductive and respiratory syndrome virus elicit immune responses in pigs. Planta, 2018; Jan 01. doi.org/10.1007/s00425-017-2836-z
6. Lim B, Khatun A, Kim SW, Nazki S, Jeong CG, Gu S, Lee J, Lee KT, Park CK, Lee SM, Kim WI and Kim KS. Polymorphisms in the porcine CD163 associated with response to PRRSV infection. Animal Genetics, 2017; Dec 28.
7. Seo BJ, Lee JH, Kang IJ, Shabir N, Khatun A, Yang MS, Park C, Kim BS and Kim WI. Effects of high molecular weight poly-γ-glutamic acid on PIGS with porcine reproductive and respiratory syndrome virus (PRRSV) infection. Acta veterinaria-Beograd, 2017; Jun 26; 67(2):153-167.
8. Shabir N, Khatun A, Nazki S, Kim BS, Choi EJ, Sun D, Yoon KJ and Kim WI. Evaluation of the cross-protective efficacy of a chimeric porcine reproductive and respiratory syndrome virus constructed based on two field strains. Viruses, 2016; Aug 22; 8(8).
9. Sun D, Khatun A, Kim WI, Cooper V, Cho YI, Wang C, Choi EJ and Yoon KJ. Attempts to enhance cross-protection against porcine reproductive and respiratory syndrome viruses using chimeric viruses containing structural genes from two antigenically distinct strains. Vaccine, 2016, Aug 5; 34(36):4335-4342.
10. Moon SH, Khatun A, Kim WI, Hossain MM, Oh Y, Cho HS. Application of next generation sequencing (NGS) system for whole-genome sequencing of porcine reproductive and respiratory syndrome virus (PRRSV). Korean J Vet Serv. 2016, 39 (1), 41-49.)
11. Khatun A, Shabir N, Seo BJ, Kim BS, Yoon KJ and Kim WI. The Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs. Journal of Virology, 2016, Apr 14; 90(9):4454-68.
12. Niu P, Shabir N, Khatun A, Seo BJ, Gu S, Lee SM, Lim SK, Kim KS and Kim WI. Effect of polymorphisms in the GBP1, Mx1 and CD163 genes on host responses to PRRSV infection in pigs. Veterinary Microbiology, 2016, Jan 15; 182:187-195.
13. Khatun A, Shabir N, Yoon KJ and Kim WI. Effects of ribavirin on the replication and genetic stability of porcine reproductive and respiratory syndrome virus. BMC Veterinary Research, 2015, Feb 7; 11: 21.
14. Shabir N, Khatun A and Kim WI. Different immunological features of two genetically distinct type 2 porcine reproductive and respiratory syndrome (PRRS) viruses. Korean J Vet Serv., 2014, 37 (1), 1-9.
15. Shabir N, Yoon BD, Khatun A, Kim BS, Shin JH, Ahn KH and Kim WI. Effects of dietary addition of β-glucan on pigs infected with Salmonella Typhimurium. J. Anim. Vet. Adv. 2013, 12(23):1657-1664.
16. Khatun A, Giasuddin M, Islam KM, Khanom S, Samad MA, Islam MR, Noor M, Bhuiyan JU, Kim WI, Eo SK and Rahman MM. Surveillance of avian influenza virus type A in semi-scavenging ducks in Bangladesh. BMC Veterinary Research, 2013, Oct 7; 9:196.
Papers Presented in Scientific Meetings/Conferences
A. Oral presentations-11 (in numbers)
I. A Khatun, N Shabir, S Nazki, CG Jeong, WI Kim. ORF1a of RVRp22, a ribavirin-resistant attenuated phenotype of PRRSV, plays an important role on viral virulence and genetic stability assessed in pigs. EuroVirology Conference (10th International Virology Summit), 2018, July 02-04, Vienna, Austria.
II. S Nazki, A Khatun, CG Jeong, S Salam, S Gu, SM Lee, WI Kim. Evaluation of pathogenicity and immunity of type 2 Porcine Reproductive and Respiratory Syndrome virus in pigs. EuroVirology Conference (10th International Virology Summit), 2018, July 02-04, Vienna, Austria.
III. CG Jeong, A Khatun, S Nazki, , WI Kim. Comparative pathogenicity of Type 1 and Type 2 Porcine Reproductive and Respiratory Syndrome virus in pregnant sows. EuroVirology Conference (10th International Virology Summit), 2018, July 02-04, Vienna, Austria.
IV. A Khatun, S Nazki, S Gu, CG Jeong, AR Kang, BJ Seo, SM Lee, KS Kim, WI Kim. Effect of polymorphisms in porcine Guanylate-Binding Protein and CD163 genes on resistance to PRRSV infection in Pigs. International Plant and Animal Genome Conference Asia (PAG Asia), 2017, May 29-31, Conrad Seoul, Seoul, South Korea.
V. Nadeem Shabir, Penxia Niu, Amina Khatun, BJ Seo, Suna Gu, SM Lee, KS Kim, WI Kim: Effect of polymorphisms of GBP1, Mx1 and CD163 genes in pigs infected with PRRSV. Korean Society of Veterinary Science, Gyeongju. Vol. 55, No. 2 Supplement, Conference 2015, October 29-30, Gyeongju, South Korea.
VI. A Khatun, N Shabir, BJ Seo, BS Kim and WI Kim. High genetic and Biological stability of a PRRSV strain resistant to lethal dose ribavirin during sequential passages in pigs. Korean Society of Veterinary Science. Vol. 55, No. 2 Supplement, Conference 2015, October 29-30, Gyeongju, South Korea.
VII. JH Lee, IJ Kang, N Shabir, A Khatun, BS Kim, WI Kim. Effects of high molecular poly-γ-glutamic acid on pigs challenged with PRRSV and its application on farm. 23rd International Pig Veterinary Society (IPVS) Congress, Mexico2014, June 8-11, Cancun, Quintana Roo, Mexico.
VIII. A Khatun, N Shabir, KJ Yoon, WI Kim. Enhanced Genetic Stability of Porcine Reproductive and Respiratory Syndrome Viruses Resistant to Ribavirin. Proceedings, Korean Society of Veterinary Science. 2013 KSVS International Symposium on One Health and the Role of Veterinary Medicine. Vol. 53, No. 3 Supplement, Conference 2013, October 10, Seoul, South Korea.
IX. N Shabir, A Khatun, EJ Choi, KJ Yoon, WI Kim. Evaluation of protective efficacy of a chimeric Porcine Reproductive and Respiratory Syndrome Virus Constructed Based on two Korean field isolates. Proceedings, Korean Society of Veterinary Science. 2013 KSVS International Symposium on One Health and the Role of Veterinary Medicine. Vol. 53, No. 3 Supplement, Conference 2013, October 10, Seoul, South Korea.
X. N Shabir, A Khatun, EJ Choi, CH Lee, D Sun, KJ Yoon, WI Kim. Immuno-modulatory Roles of Structural Proteins of Porcine Reproductive and Respiratory Syndrome Viruses. ASV (American Society for Virology) 31st Annual Meeting-2012, July 21-25, University of Wisconsin-Madison, Madison, Wisconsin, USA.
XI. A Khatun, EJ Choi, CH Lee, KJ. Yoon, WI. Kim. Antiviral effect of various mutagens against PRRS virus. CRWAD (Conference of Research Workers in Animal Diseases) 92nd Annual Meeting-2011, December 4-6, 2011 and 2011 International PRRS symposium, December 2-3, 2011. Marriott, Downtown Magnificent Mile, Chicago, Illinois, USA.
B. Poster presentations-17 (in number)
I.
II. S.-M. Lee, B. Kim, A. Khatun, S. Nazki, S. Salam, S. Gu, C.-G. Jeong, W.-I. Kim. Respiratory innate immune response and dendritic cell/macrophage network dynamics upon porcine reproductive and respiratory syndrome virus (PRRSV) JA142 infection in pigs. EVIW (6th European Veterinary Immunology Workshop) 2018. September 5-7, Utrecht, The Netherlands.
III. B. Lim, A. Khatun, S.-W. Kim, S. Nazki, K.-T. Lee, C.-K. Park, S.-M. Lee, W.-I. Kim, K.-S. Kim. Characterization and Expression Analysis of Porcine CD163 Gene in PRRSV infected Pigs. International Plant & Animal Genome (PAG) XXVI Conference, 2018. January 12-17, San Diego, CA, USA.
IV. S.-M. Lee, B. Kim, A. Khatun, S. Nazki, S. Salam, S. Gu, C.-G. Jeong, W.-I. Kim. Porcine reproductive and respiratory syndrome virus JA142 induces a protective T-cell mediated immune responses in pigs. 98th Conference of Research Workers in Animal Diseases (CRWAD), Annual Meeting-2017, December 3-5. Marriott, Downtown Magnificent Mile, Chicago, Illinois, USA.
V. S.-M. Lee, N. Shabir, A. Khatun, S. Nazki, S. S. Gu, M.-S. Yang, B. Kim, W.-I. Kim. Association of immune responses of porcine alveolar macrophages and host immune responses against porcine reproductive and respiratory syndrome viruses. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), 2017, Oct 29-Nov 2, Kanazawa, Japan.
VI. A.-R. Kang, W.-I. Kim, A. Khatun, S. Nazki, C.-G. Jeong, B.-J. Seo, B.-S. Kim. Evaluation of antiviral efficacy of synthetic natural products against PRRSV replication. Korean Society of Veterinary Science (KSVS), Vol. 55, No. 3 Supplement, Conference 2016. October 27-28, Jinju, South Korea.
VII. C.-G. Jeong, B.-J. Seo, A. Khatun, S. Nazki, A.-R. Kang, W.-I. Kim. Detection of toxins and toxin genes of Clostridium novyi type B field isolates. Korean Society of Veterinary Science (KSVS), Vol. 55, No. 3 Supplement, Conference 2016. October 27-28, Jinju, South Korea.
VIII. A Khatun, WI Kim, S Nazki, AR Kang, CG Jeong, J Juhng, BJ Seo. Assessment of the replication efficiency of porcine reproductive and respiratory syndrome viruses (PRRSVs) in porcine alveolar macrophages (PAMs) at different age of host-pigs. Korean Society of Veterinary Science (KSVS), Vol. 55, No. 3 Supplement, Conference 2016. October 27-28, Jinju, South Korea.
IX. P Niu, N Shabir, A Khatun, S Gu, KS Kim, SM Lee, WI Kim. Validation of Genetic Makers for Pig Resistance to PRRSV infection. International Plant & Animal Genome Conference, 2015. January 10-14, San Diego, CA, USA.
X. N Shabir, A Khatun, EJ Choi, KJ Yoon, WI Kim. Evaluation of protective efficacy of a chimeric porcine reproductive and respiratory syndrome virus. ASV (American Society for Virology) 33rd Annual Meeting-2014, June 21-25, Colorado State University, Fort Collins, Colorado, USA.
XI. A Khatun, N Shabir, KJ Yoon, WI Kim. Effects of ribavirin on porcine reproductive and respiratory syndrome virus replication and genetic stability. ASV (American Society for Virology) 33rd Annual Meeting-2014, June 21-25, Colorado State University, Fort Collins, Colorado, USA.
XII. JS Mo, A Khatun, N Shabir, BD Yoon, WI Kim. Effects of dietary addition of β-glucan on Salmonella infection in pigs. 22nd International Pig Veterinary Society (IPVS) Congress, IPVS2012 Korea, June 10-13, Jeju Island, Korea.
XIII. N Shabir, A Khatun, EJ Choi, CH Lee, KJ Yoon, WI Kim. Differential cytokine expression by porcine alveolar macrophages infected with different porcine reproductive and respiratory syndrome viruses. 22nd International Pig Veterinary Society (IPVS) Congress, IPVS2012 Korea, June 10-13, Jeju Island, Korea.
XIV. A Khatun, K.-J. Yoon, W.-I. Kim. Effect of four different antiviral mutagens against PRRS virus replication. 22nd International Pig Veterinary Society (IPVS) Congress, IPVS2012 Korea, June 10-13, Jeju Island, Korea.
XV. JH Lee, N Shabir, A Khatun, IJ Kang, WI Kim. Evaluation of antiviral effect of poly-γ-glutamate against porcine reproductive and respiratory syndrome virus and immune modulation in pigs. 22nd International Pig Veterinary Society (IPVS) Congress, IPVS2012 Korea, June 10-13, Jeju Island, Korea.
XVI. A Khatun, KJ Yoon, WI Kim. Ribavirin and 5-fluorouracil are highly effective against the replication of Porcine Reproductive and Respiratory Syndrome virus. ASV (American Society for Virology) 31st Annual Meeting-2012, July 21-25, University of Wisconsin-Madison, Madison, Wisconsin, USA.
XVII. A Khatun, EJ Choi, CH Lee, D Sun, KJ Yoon, WI Kim. Different immunobiological features of two genetically distinct type 2 PRRS viruses. CRWAD (Conference of Research Workers in Animal Diseases) 92nd Annual Meeting-2011, December 4-6, 2011 and 2011 International PRRS symposium, December 2-3, 2011. Marriott, Downtown Magnificent Mile, Chicago, Illinois, USA.
Novel DNA sequences published in National Center for Biotechnology Information (NCBI), USA
Species Gene GenBank Accession number Sequence #
I PRRSV (Mutant viruses) Whole genome KP256233 & KM386622 02
II PRRSV (Chimeric virus) Whole genome KP704287 01
III PRRSV (field isolates) Whole genome KY434183 & KY434184 02
IV Duck adenovirus 1 (EDS’76) Hexon KU053276~ KU053281 06
V Porcine circovirus 2 Capsid (CP) MF631805~06, MF6318 08~10,
MF631812, MF631814~ MF631834 27
VI Porcine circovirus 3 Capsid (CP) MF631803~04, MF631807,
MF631811 & MF631813 05
VII Sus scrofa (swine) CD163 molecule NM_213976.1 01
VIII Sus scrofa (swine) MX1 NM_214061.2 01
IX Sus scrofa (swine) GBP1 NM_001128473.1 01
X Clostridium novyi type B
(field isolate) Whole genome CP029458~60 03
a. Chromosome CP029458 01
b. Plasmid, pCN1 CP029459 01
c. Plasmid, pCN2 CP029460 01
Total numbers of sequences 49
Current profession
Current professional activities type:ResearchTeachingCurrently, I’m working as an Assistant Professor and Chairman of the department of Pathology, Faculty of Animal Science and Veterinary Medicine (FASVM), Sher-e-Bangla Agricultural University (SAU), Dhaka, Bangladesh. My major roles are teaching (undergraduates and graduates), research and administration (as chairman of this department). I have an extended interests for molecular works on host-pathogen interactions, immunology of infectious diseases of farm animals, different RNA viruses and their preventive control strategies i.e. FMDV, PPRV, Influenza virus, Rabies virus and PRRSV), bovine tuberculosis and antimicrobial resistance mechanism and control of clinical and environmental pathogens as well. Previously, I was employed as a "Postdoctoral Research Fellow" following my doctorate (PhD) degree at the College of Veterinary Medicine, Chonbuk National University (CBNU), Republic of Korea; wherein, I was focusing on couple of research projects and also engaged successfully as a "Research In-Charge" for graduates (MS and PhD program) in the department of Veterinary Immunology under the same college and university. My previous researches (major) has been focused mostly on the functional genomics of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) largely prospecting of viral pathogenesis intended to address two major hurdles faced by PRRS vaccinology i.e. low genetic fidelity and limited cross-protection. PRRSV, a quickly evolving RNA virus, is the most challenging threat to the swine industries worldwide. Previously, we have been developed a candidate strain of PRRSV through mutagen-driven lethal mutagenesis which possesses high genetic stability evinced during replication sequentially in pigs passage by passage. And, the cross-protective efficacy against PRRSV strains was enhanced by introducing heterogeneity in the neutralizing epitopes constructed into an immunogenic backbone of PRRSV using reverse-genetics approaches. Wherein, we have been developed a chimeric vaccine platform for PRRSV aimed to enhance the heterologous protection against highly divergent PRRSV strains. Besides, to gain the holistic view of PRRS, we have also been focusing on the host-genetics associated with increased resistance and immune-responses against PRRSVs to understand the genetic basis of the disease resistance in pigs.
Affiliations
Conference of Research Workers in Animal Diseases (CRWAD)American Society for Virology (ASV)International Plant and Animal Genome (PAG)International Pig Veterinary Society (IPVS)International Cytokine and Interferon Society (ICIS)The Korean Society of Veterinary Science (KSVS)Bangladesh Veterinary Council (BVC)Bangladesh Society for Veterinary Education and Research (BSVER)Ecology and EvolutionVeterinary Licensure in BangladeshPresentation given
ORAL Presentation' 2018 (Selected)ORF1a of RVRp22, a ribavirin-resistant attenuated phenotype of PRRSV, plays an important role on viral virulence and genetic stability assessed in pigsVienna, Austria (July 02-04)Event: Euro Virology 2018 10th International Virology Summit, 2018ORAL Presentation' 2017Effect of polymorphisms in porcine Guanylate-Binding Protein and CD163 genes on resistance to PRRSV infection in PigsConrad Seoul, Seoul, Republic of Korea (May 29-31)Event: International Plant and Animal Genome Conference Asia (PAG Asia), 2017ORAL Presentation' 2015High genetic and Biological stability of a PRRSV strain resistant to lethal dose ribavirin during sequential passages in pigsGyeongju, Republic of Korea.Event: The Korean Society of Veterinary Science ( October 29-30)ORAL Presentation'2014Effects of high molecular poly-γ-glutamic acid on pigs challenged with PRRSV and its application on farmCancun, Quintana Roo, Mexico (June 8-11)Event: 23rd International Pig Veterinary Society (IPVS) Congress, Mexico2014ORAL Presentation'2013Enhanced Genetic Stability of Porcine Reproductive and Respiratory Syndrome Viruses Resistant to RibavirinSeoul, Republic of Korea (October 10)Event: The Korean Society of Veterinary Science (KSVS) International Symposium on One Health and the Role of Veterinary MedicineORAL Presentation'2013Evaluation of protective efficacy of a chimeric Porcine Reproductive and Respiratory Syndrome Virus Constructed Based on two Korean field isolatesSeoul, Republic of Korea (October 10)Event: The Korean Society of Veterinary Science (KSVS) International Symposium on One Health and the Role of Veterinary MedicineORAL Presentation'2012Immuno-modulatory Roles of Structural Proteins of Porcine Reproductive and Respiratory Syndrome VirusesUniversity of Wisconsin-Madison, Madison, Wisconsin, USA (July 21-25)Event: ASV (American Society for Virology) 31st Annual Meeting-2012ORAL Presentation'2011Antiviral effect of various mutagens against PRRS virusMarriott, Downtown Magnificent Mile, Chicago, Illinois, USA (December 2-5)Event: Conference of Research Workers in Animal Diseases (CRWAD) 92nd Annual Meeting-2011 -
Other Awards
Sep 2015Postdoctoral Research FellowshipChonbuk National University (CBNU) Postdoctoral Research Fellowship Period: Sep’2015 ~ presentAug 2010PhD research FellowshipChonbuk National University (CBNU) PhD research Fellowship Period: Aug’2010 ~ Aug’2015Feb 2018GOLD MEDALThe ‘Chancellor’s Gold Medal’ award for excellence in MS degree Awarded: on Feb’2018May 2018Invited SpeakerInternational Animal Biotechnology Symposium'2018 Chungbuk National University (CNU), Republic of KoreaJul 2014Excellent poster presentation awardAwarded by The Korean Society of Veterinary Science (KSVS)Oct 2013Excellent oral presentation awardAwarded by The Korean Society of Veterinary Science (KSVS)
