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Membership type: full

Gloria Virginia Lopez Gonzalez

Country of origin: Uruguay Currently in: Uruguay, Ciudad de la Costa, Canelones General field of specialization: Chemical Sciences
Academic Background

Degrees

2006 Doctorate Chemical Sciences
Research and Profession

Current Research Activities

Interdisciplinary

R+D+i of bioactive compounds, considering green chemistry principles, for the treatment of non-communicable diseases, such as cancer, diabetes, hypertension and cariovacular diseases.

Research Keywords: 
bioactive compounds
green chemistry
non-communicable diseases

Publications resulting from Research: 


M. Ingold, R. Dapueto, S. Victoria, G. Galliussi, C. Batthyany, M. Bollati-Fogolín, D. Tejedor, F. García-Tellado, J.M. Padron, W. Porcal, Gloria V. Lopez. A green multicomponent synthesis of tocopherol analogues with
antiproliferative activities. Eur. J. Med. Chem. 2018, 143, 1888-1902.

M. INGOLD , L. COLELA , R. DAPUETO , GLORIA V. LÓPEZ* , W. PORCAL* Ugi Four-component Reaction (U-4CR) Under Green Conditions Designed for Undergraduate Organic Chemistry Laboratories World Journal of Chemical Education 2017, 55, 153 - 157.

M. INGOLD , R. DAPUETO , GLORIA V. LÓPEZ* , W. PORCAL* Una reacción multicomponente verde en el laboratorio de química orgánica. Educación Química 2016, 27,15 - 20.

N. RIOS , L. PIACENZA , M. TRUJILLO , A. MARTINEZ , V. DEMICHELI , C. PROLO , MARÍA N. ALVAREZ , GLORIA V. LÓPEZ* , R. RADI* Sensitive detection and estimation of cell-derived peroxynitrite fluxes using fluorescein-boronate. Free Rad. Biol. Med. 2016, 101, 284 - 295.

M. INGOLD , GLORIA V. LÓPEZ , W. PORCAL Green conditions for Passerini three-component synthesis of Tocopherol analogues 2014, ACS Sustainable Chemistry & Engineering,2, 1093 - 1097.

F. ROSS , P. HERNÁNDEZ , W. PORCAL , GLORIA V. LÓPEZ , H. CERECETTO , M. GONZÁLEZ , T. BASIKA , C. CARMONA , G. MAGGIOLI , M. BONILLA , V. N. GLADYSHEV , M. BOIANI , G. SALINAS Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites PLoS ONE 2012, 7 4.

F. BLANCO , ANA M. FERREIRA , GLORIA V. LÓPEZ , LUCÍA BONILLA , M. GONZÁLEZ , H.
CERECETTO , A. TROSTCHANSKY , H. RUBBO 6-METHYL-NITROARACHIDONATE:A NOVEL ESTERIFIED NITROALKENE WHICH POTENTLY INHIBITS PLATELET AGGREGATION AND EXERTS cGMP MEDIATED VASCULAR RELAXATION. Free Radical Biology and Medicine 2011, 50, 3, 411 - 418.

GLORIA V. LÓPEZ , M. CABRERA , LUIS E. GÓMEZ , M. BREIJO , C. PINTOS , H. BOTTI , S.
RAYMONDO , A. VETTORAZZI , A. LÓPEZ DE CERAIN , A. MONGE , H. RUBBO , M. GONZÁLEZ , H. CERECETTO Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents .
Drug and Chemical Toxicology 2011, 34, 3, 285 - 293.

GLORIA V. LÓPEZ* , LUIS E. GÓMEZ , N. CAMPILLO , JUAN A PÁEZ , K. GILES , J. ATKINSON , M. GONZÁLEZ , H. RUBBO , H. CERECETTO Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity . Bioorg. Med. Chem. 2009, 17, 8143 - 8148.

GLORIA V. LÓPEZ , F. BLANCO , P. HERNÁNDEZ , A. FERREIRA , O.E. PIRO , C. BATTHYÁNY , M. GONZÁLEZ , H. RUBBO , H. CERECETTO Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical and biological
characterization Bioorg. Med. Chem. 2007, 15, 6262 - 6272.

K. CHEGAEV , L. LAZZARATO , B. ROLANDO , GLORIA V. LÓPEZ , C. CENA , R. FRUTTERO , A. GASCO Amphiphile NO-donor Antioxidants. Chemmedchem 2007, 2, 234 - 240.



Current profession

Current professional activities type: 
Research
Teaching
Associate Professor at Facultad de Química, Universidad de la República, Montevideo, Uruguay. As Professor of Organic Chemistry, I carry out teaching, research and extension tasks. Associate Researcher at Institut Pasteur de Montevideo, Montevideo, Uruguay. In the IPMONT I am part of an interdisciplinary group of researchers working on the development of new strategies to treat chronic noncommunicable diseases such as metabolic and cardiovascular diseases.

Affiliations

Laboratory of Vascular Biology and Drug Development, Institut Pasteur de Montevideo.