Member Profile
Ambeu-Loko N'ta Christelle Mélissa
Country of origin: Côte d'Ivoire Currently in: Côte d'Ivoire, Abidjan General field of specialization: Chemical Sciences-
Degrees
2015 Doctorate Chemical Sciences -
Current Research Activities
Chemical Sciences
Our research activities are located at the Chemistry-Biology interface. Indeed, my research activities began with my doctoral thesis carried out at the University of Rennes 1 under the scientific direction of Professor Jean-Pierre BAZUREAU (France) and Professor Janat Akhanovna MAMYRBEKOVA-BÉKRO (Côte d'Ivoire), from 2012 to 2015. My research work concerned the development of a multi-step synthesis strategy for 169 new compounds (5-arylidene rhodanines, “aza” and “aza azoles” derivatives) comprising several heterocyclic platforms. Five (05) of these compounds have a significant anticancer potential and can provide access to the construction of a new platform of promising kinase inhibitor molecules. This work has led to several publications in indexed international journals (Molecules, Current Microwave Chemistry, Medicinal Chemistry Research, Chemistry of Heterocyclic Compounds, Molecular Diversity and Computational Molecular Bioscience). I did postdoctoral internships at the University of Rennes 1 (January 2016 – February 2018) and at University of Nantes (2019, 2022) where I worked respectively on the synthesis of rhodanines N-(3-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)propyl)sulfonamides and on the synthesis of 2-aminochloropyridines and diamino-(dihydro)-triazines which gave interesting biological activities. My stay abroad had a positive impact since it gave birth to an international Ivorian-Nantes partnership. After my recruitment at Felix HOUPHOUET-BOIGNY University (UFR SSMT) in 2018, I joined the Laboratory of Constitution and Reaction of Matter (LCRM) where I carried out research on the synthesis of compounds from the combination of two antimicrobial pharmacophores (pyrimidine, benzimidazole), SecA inhibitors. At the Laboratory of Constitution and Reaction of Matter (LCRM), I am working on a new research project which concerns the synthesis of compounds resulting from the combination of two pharmacophores (pyrimidine, benzimidazole) antimicrobials, SecA inhibitors. This work led to three publications: one is published (Organic Preparations and Procedures International 2023, DOI:10.1080/00304948.2023.2178212) and two are submitted for publication.
Publications resulting from Research:
P1. FANTE Bamba, AMBEU-LOKO N’ta Christelle Mélissa, COULIBALY Souleymane, SORO Yaya et COUSTARD Jean-Marie
An Original Transposition of 4-Fluorobenzylamino Group from 1-(4-Fluorobenzylamino)-1-methylsulfanyl-2-nitroethylene in Triflic Acid
Organic Preparations and Procedures International 2023, DOI:10.1080/00304948.2023.2178212
P2. Coulibaly Wacothon Karime, Affi Sopi Thomas, James Titah, Mamadou Guy-Richard Koné, Affoué Estelle Brigitte Yao, Camille Déliko Dago, Christelle N’ta Ambeu, Jean-Pierre Bazureau, Josh Daniel McLoud, Benié Anoubilé, Nahossé Ziao
Anti-proliferative Activity Study on 5-Arylidene Rhodanine Derivatives Using Density Functional Theory (DFT) and Quantitative Structure Activity Relationship (QSAR)
International Journal of Computational and Theoretical Chemistry 2022; 10(1): pp. 1-8
P3. Wacothon Karime Coulibaly, Jean Stéphane N’dri, Mamadou Guy-Richard Koné, Camille Déliko Dago, Christelle N’ta Ambeu, Jean-Pierre Bazureau, Nahossé Ziao
Studies of the Chemical Reactivity of a Series of Rhodanine Derivatives by Approaches to Quantum Chemistry
Computational Molecular Bioscience 2019, 9, pp. 49-62.
P4. Christelle N'Ta Ambeu, Rémy Le Guével, Anne Corlu, Janat Akhanovna Mamyrbekova and Jean-Pierre Bazureau
A practical multi-step synthesis of ethyl N-functionalized β-aminobenzimidazole acrylate derivatives as promising cytotoxic agents
Molecular Diversity 2018, 22(3), pp. 685-708.
P5. Camille Déliko Dago, Christelle N'ta Ambeu, Wacothon Karime Coulibaly, Yves-Alain Békro, Janat A. Mamyrbekova-Békro, Rémy Le Guével, Anne Corlu and J-P. Bazureau.
Investigation on the synthesis of new 3-(4-(arylalkoxy)phenylethyl)-2-thioxo-1,3-thiazolidine-4-ones and their biological evaluation against cancer cells.
Chemistry of Heterocyclic Compounds 2017, 53(3), pp. 341–349.
P6. Christelle N'ta Ambeu, Camille Déliko Dago, Wacothon Karime Coulibaly, Yves-Alain Békro, Janat A. Mamyrbekova-Békro, Béatrice Foll-Josselin, Audrey Defontaine, Claire Delehouzé, Stéphane Bach, Sandrine Ruchaud, Rémy Le Guével, Anne Corlu, Philippe Jéhan, Fabian Lambert, Nicolas Le Yondre and J-P. Bazureau
Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors
Medicinal Chemistry Research 2016, 25, pp. 2940–2958.
P7. Christelle N’ta Ambeu; Camille Déliko Dago; Wacothon Karime Coulibaly; Yves-Alain Békro; Janat A. Mamyrbekova-Békro; Jean-Pierre Bazureau.
Microwave Assisted Prospective Synthesis of New 5-Arylidene Rhodanine Derivatives Bearing a 3-[4-(3-Aminopropyl)-piperazin-1-yl]propyl Side Chain
Current Microwave Chemistry 2016, vol.3, number 2, pp.145-156 (12).
P8. Camille Déliko Dago, Christelle N'ta Ambeu, Wacothon Karime Coulibaly, Yves-Alain Békro, Janat A. Mamyrbekova-Békro, Audrey Defontaine, Blandine Baratte, Stéphane Bach, Sandrine Ruchaud, Rémy Le Guével, Myriam Ravache, Anne Corlu, Jean Pierre Bazureau.
Synthetic development of new 3-(4-arylmethylamino)butyl-5-arylidene-rhodanines under microwave irradiation and their effects on tumor cell lines and against protein kinases.
Molecules 2015, 20, pp.12412-12435.
P9. KABRAN Guy Roger, AMBEU N’ta Christelle M., MAMYRBEKOVA-BÉKRO Janat Akhanovna, BÉKRO Yves-Alain
Phénols et Flavonoïdes Totaux Dans Les Extraits Organiques de Dix Plantes Utilisées Dans la Tradithérapie du Cancer du Sein en Côte d’Ivoire
European Journal of Scientific Research 2012, 68(2), pp.182-190.
P10. KABRAN Guy Roger Mida, AMBEU N’ta Christelle, MAMYRBEKOVA-BÉKRO Janat Akhanovna, BÉKRO Yves-Alain
CCM D’extraits Sélectifs de 10 Plantes Utilisées Dans le Traitement Traditionnel du Cancer du Sein en Côte d’Ivoire
European Journal of Scientific Research 2011, 63(4), pp. 592-603.
Current profession
Current professional activities type:OtherTeacher Researcher
Workshop and Conference Attended
2017 http://www.sciforum.net/conference/ecmc-3; https://sciforum.net/manuscripts/4687/manuscript.pdf Synthesis of ethyl N-functionalized β-amino benzimidazole acrylate derivatives and their cytotoxic biological evaluationAffiliations
University of NantesPresentation given
2016Synthesis of pentamidine analogs bearing heterocyclic platforms and their biological evaluationsAmboise, FranceEvent: 30th french-belgian Days (JFB) of pharmacochemistry -
Other Awards
Aug 2023Grant agreement from Schlumberger FoundationThe Faculty for the Future program, launched in 2004, awards fellowships to women from developing and emerging economies to pursue PhD or Post-doctoral research in Science, Technology, Engineering and Mathematics (STEM) fields at leading universities worldwide. The Schlumberger Foundation is committed to gender parity in science and recognizes that full access to and participation in a STEM curriculum is essential for the empowerment of women and girls. By facilitating STEM research for women scientists in emerging economies, scientific and technological advances will be enhanced in the local communities and regions from where selected candidates are awarded for this program. The fellowship award is subject to the following conditions: a) compliance with and continued veracity of the information provided in application form; b) acceptance and enrolment at one of the institutions listed in application form and c) the signing of a Grant Agreement to be established between the grantee and the Schlumberger Foundation and, in some cases, also between the Schlumberger Foundation and host institution.Oct 2022Advanced training scholarship for teacher-researchers AMRUGESupport for the Modernization and Reform of Universities and High School in Ivory CoastJun 2015Scholarship outside Ivory Coast from DOBDirection of Guidance and Scholarships) of the Ministry of Higher Education and Scientific Research of Ivory Coast (MESRS-CI)Jun 2014Scholarship outside Ivory Coast from DOBDirection of Guidance and Scholarships of the Ministry of Higher Education and Scientific Research of Ivory Coast (MESRS-CI)Jun 2013Scholarship outside Ivory Coast from DOBDirection of Guidance and Scholarships of the Ministry of Higher Education and Scientific Research of Ivory Coast (MESRS-CI)Jun 2012Ivorian scholarship from DOBDirection of Guidance and Scholarships of the Ministry of Higher Education and Scientific Research of Ivory Coast (MESRS-CI)
