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Membership type: full

Celia Quijano

Country of origin: Uruguay Currently in: Uruguay, Montevideo General field of specialization: Structural, Cell and Molecular Biology
Academic Background

Degrees

2019 Chemical Sciences
Research and Profession

Current Research Activities

Structural, Cell and Molecular Biology

Metabolic alterations in cell senescence

Research Keywords: 
cell senescence
mitochondria
bioenergetics
fatty acid metabolism
oxidants
antioxidants

Publications resulting from Research: 


Demicheli V, Moreno D, Jara G, Lima A, Carballal S, Rios N, Batthyany C, Ferrer- Sueta G, Quijano C, Estrín D, Martí M, Radi R.
Mechanism of the Reaction of human Mn-Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine-34. Biochemistry, 2016. [Epub ahead of print].

Quijano C, Trujillo M, Castro L, Trostchansky A. Interplay between oxidant species and energy metabolism. Redox Biol. 2016; 8:28-42.

Martino Adami PV, Quijano C, Magnani N, Galeano P, Evelson P, Cassina A, Do Carmo S, Leal MC, Castaño EM, Cuello AC, Morelli L. Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease. J Cereb Blood Flow Metab. 2015 [Epub ahead of print]

Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle. 2012; 11(7):1383-92.

Valez V, Aicardo A, Cassina A, Quijano C, Radi R. Oxidative Stress in Mitochondria Principles of Free Radical Biomedicine. Editors: K. Pantopoulos and H. Schipper. Nova Science Publishers Inc. 2012; 2:283 – 302.

Yadav H, Quijano C, Kamaraju KA, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, and Rane SG. Protection from Obesity and Diabetes by Blockade of TGF-b/Smad3 Signaling. Cell Metabolism. 2011; 14:67-79.

Wu JJ, Quijano C, Wang J, Finkel T. Metabolism meets autophagy. Cell Cycle. 2010; 9:4780-4781.

Wu JJ, Quijano C, Chen E, Liu H, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M and Finkel T. Mitochondrial dysfunction and oxidative stress mediate physiological impairment induced by the disruption of autophagy. Aging. 2009; 1:425-437.

Hernandez-Saavedra D, Quijano C, Demicheli V, Souza JM, Radi R, McCord JM. Thiol-sensitive mutant forms of human SOD2, L60F, and I58T: The role of Cys 140. Free Radic. Biol. Med. 2010; 48:1202-1210.

Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas L. Cyclosporine A-Induced Nitration of Tyrosine 34 MnSOD in Endothelial Cells: Role of Mitochondrial Superoxide. Cardiovasc Res. 2010; 87:356-365.

Liu J, Cao L, Chen J, Song S, Lee I, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L, Ahn B, Kumar NJ, Rovira II, Daniels MP, Xu X, van Lohuizen M, Motoyama N, Deng C and Finkel T. Deletion of Bmi1 induces oxidative stress and activates the DNA damage response pathway. Nature. 2009; 459:388-393.

González-Pérez S, Quijano C, Romero N, Melø TB, Radi R, Arellano JB. Peroxynitrite inhibits electron transport on the acceptor side of higher plant photosystem II. Arch Biochem Biophys. 2008; 473:25-33.

Quijano C, Castro L, Peluffo G, Valez V and Radi R. Enhanced mitochondrial superoxide formation in hyperglycemic endothelial cells: Direct measurements and formation of hydrogen peroxide and peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 2007; 293: H340-14.

Demicheli V, Quijano C, Alvarez B, Radi R. Inactivation and nitration of human SODs by fluxes of nitric oxide and superoxide. Nitric oxide reaction with superoxide outcompetes SOD dismutation, generating peroxynitrite. Free Radic. Biol. Med. 2007; 42:1359-1368.

Tortora V, Quijano C, Freeman BA, Radi R, Castro L. Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione and peroxynitrite: Defining de mechanisms and relative contribution of these species to aconitase inactivation. Free Radic. Biol. Med. 2007; 42:1075-88.

Ye Y, Quijano C, Robinson KM, Ricart KC, Strayer AL, Shacka JJ, Kirk M, Barnes S, Radi R, Beckman BS, Estévez AG. Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine containing peptides. J. Biol. Chem. 2007; 282:6324-37.

Quijano C, Cassina A, Castro L, Rodríguez R and Radi R. Peroxynitrite: a mediator of nitric-oxide dependent mitochondrial dysfunction in pathology. Nitric Oxide, Cell Signaling, and Gene Expression. Santiago Lamas and Enrique Cadenas eds. Taylor & Francis Group, Florida. 2006; 99-143.

Quijano C, Romero N and Radi R. Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: Modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic. Biol. Med. 2005; 39, 728-41.

Radi R, Cassina A, Hodara R, Quijano C and Castro L. Peroxynitrite reactions and formation in mitochondria. Free Radic. Biol. Med. 2002; 33, 1451-64.

Ferrer-Sueta G, Quijano C, Alvarez B, Radi R. Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite. Methods Enzymol. 2002; 349:23-37.

Quijano C, Hernandez-Saavedra D, Castro L, McCord JM, Freeman BA and Radi R. Reaction of peroxynitrite with Mn-superoxide dismutase: Role of the metal center in decomposition kinetics and nitration. J. Biol. Chem. 2001; 276, 11631-8.

Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. J Biol Chem. 2001; 276:46017-23.

Cerecetto H, Di Maio R, Gonzalez M, Risso M, Sagrera G, Seoane G, Denicola A, Peluffo G, Quijano C, Stoppani AO, Paulino M, Olea-Azar C, Basombrio MA. Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. Structure-activity relationships. Eur. J. Med. Chem. 2000; 35:343-50.

Cerecetto H, Di Maio R, González M, Risso M, Saenz P, Seoane G, Denicola A, Peluffo G, Quijano C and Olea-Azar C. 1,2,5,-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships. J. Med. Chem. 1999; 42:1941-1950.

Quijano C, Alvarez B, Gatti RM, Augusto O and Radi R. Pathways of peroxinitrite oxidation of thiol groups. Biochem. J. 1997; 322, 167-73.



Current profession

Current professional activities type: 
Research
Teaching
Associate Professor of Biochemistry at the School of Medicine in the Universidad de la República (UDELAR), Uruguay

Workshop and Conference Attended

2015 Uruguay Mini-Symposium ICGEB-CEINBIO: Frontiers in Biomedical Research
2014 Uruguay 1st Conference of the South American Chapter of Cell Stress Society International
2014 USA Cold Spring Harbor Laboratory Meeting Molecular Genetics of Aging
2013 Cambridge, United Kingdom Cell Senescence in Cancer and Ageing
2015 Brazil 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq)
2014 Uruguay XV Jornadas de la Sociedad Uruguaya de Biociencias
2013 Uruguay 8vas Jornadas de la Sociedad de Biooquímica y Biología Molecular
2011 Uruguay 7as Jornadas de la Seccional Bioquímica y Biología Molecular de la Sociedad Uruguaya de Biociencias
2008 USA Gordon Research Conference. Oxygen Radicals
2007 Uruguay V Meeting of the Society for Free Radical Research – South American Group
2006 Switzerland XIII Biennal Meeting of the Society for Free Radical Research International
2005 Brazil IV Meeting of the South American Group of the Society for Free Radical Biology and Medicine
2004 Argentina Society for Free Radical Research 12th Biennal Meeting
2002 USA 9th Annual Meeting of the Oxygen Society

Affiliations

Society for Free Radical Biology and Medicine (SFRBM)

Presentation given

2015
Metabolic reprogramming in cell senescence.
Montevideo, Uruguay
Event: Mini-Symposium ICGEB-CEINBIO: Frontiers in Biomedical Research
2014
Senescence: a cellular response to stress

Montevideo, Uruguay
Event: 1st Conference of the South American Chapter of Cell Stress Society International
2014
Inhibition of lipid synthesis activates the DNA damage response and triggers premature senescence in human fibroblasts
Cold Spring Harbor, NY, USA
Event: Cold Spring Harbor Laboratory Meeting Molecular Genetics of Aging
2011
El metabolismo de la célula senescente y su influencia sobre el fenotipo secretor
Montevideo, Uruguay
Event: 7as Jornadas de la Seccional Bioquímica y Biología Molecular de la Sociedad Uruguaya de Biociencias
2006
Enhanced mitochondrial superoxide formation during hyperglycemic challenge to endothelial cells: Impact on intracellular hydrogen peroxide levels and peroxynitrite formation
Davos, Switzerland
Event: XIII Biennal Meeting of the Society for Free Radical Research International
2002
Superoxide and nitric oxide mitochondrial interactions in hyperglycemic vascular endothelial cells
San Antonio, Texas, USA
Event: 9th Annual Meeting of the Oxygen Society
Prizes, Grants and Awards

Other Awards

May 2008
National Institutes of Health (NIH) Intramural Research Training Award (IRTA) Fellowship.
Postdoctoral fellowship at the National Institutes of Health (NIH) in Bethesda, Maryland, USA (2008-2011).
Apr 2004
Young Investigator Award from the “Society for Free Radical Biology and Medicine"
Award to students attending the Society for Free Radical Biology and Medicine (SFRBM) 12th Biennial Meeting in Buenos Aires, Argentina
Apr 2006
Young Investigator Award from the “Sociedad Uruguaya de Biociencias (SUB)”.
Honorific Mention awarded by the Uruguayan Society of Bioscience
Nov 2011
Sistema Nacional de Investigadores , Nivel I
National System of Researchers, level I”. Award given by the “Agencia Nacional de Investigación e Innovación (ANII)" (National Agency for Investigation and Innovation (ANII). Uruguay.