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Membership type: full

Sumbal Saba

Country of origin: Pakistan Currently in: Brazil, Goiânia General field of specialization: Chemical Sciences
Academic Background

Degrees

2016 Doctorate Chemical Sciences
Research and Profession

Current Research Activities

Chemical Sciences

Chemistry; Organic Chemistry; Synthetic Organic Chemistry; Catalysis; Homogeneous and Heterogeneous; Green Chemistry; Photochemistry; Electrochemistry; Medicinal Chemistry

Research Keywords: 
Organic Chemistry
synthesis
green chemistry
new protocol in organic synthesis
organochalcogen chemistry

Publications resulting from Research: 


1. S. Saba, C. R. Dos Santos, B. R. Zavarise, A. A. S. Naujorks, M. S. Franco, A. R. Schneider, M. R. Scheide, R. F. Affeldt, J. Rafique, A. L. Braga. Eosin Y‐catalyzed photo‐induced direct C(sp2)‐H bond azo coupling of imidazo‐heteroarenes and anilines with aryl diazonium salts. Chemistry - A European Journal, 2019. DOI: doi.org/10.1002/chem.201905308.

2. A. G. Meirinho, V. F. Pereira, G. M. Martins, S. Saba, J. Rafique, A. L. Braga, S. R. Mendes. Electrochemical Oxidative C(sp2)–H Bond Selenylation of Activated Arenes. European Journal of Organic Chemistry, v. 2019, p. 6465-6469, 2019.

3. Y. Fakhria, J. Rahmanib, C. A. F. Oliveira, L. T. Franco, C. H. Corassin, S. Saba, J. Rafiquee, A. M. Khaneghahf. Aflatoxin M1 in human breast milk: A global systematic review, meta-analysis, and risk assessment study (Monte Carlo simulation). Trends in Food Science & Technology, v. 88, p. 333-342, 2019.

4. J. Rafique, S. Saba, M. S. Franco, L. Bettanin, A. R. Schneider, L. T. Silva, A. L. Braga. Direct, metal-free C(sp2)-H chalcogenation of indoles and imidazopyridines with dichalcogenides, catalyzed by KIO3. Chemistry - A European Journal, v. 24, p. 4173-4180, 2018.

5. G. M. Almeida, J. Rafique, S. Saba, T. Siminski, N. S. R.S. Mota, D. W. Filho, A. L. Braga, R. C. Pedrosa, F. Ourique. Novel selenylated imidazo[1,2- a ]pyridines for breast cancer chemotherapy: Inhibition of cell proliferation by Akt-mediated regulation, DNA cleavage and apoptosis. Biochemical and Biophysical Research Communications, v. 503, p. 1291-1297, 2018.

6. J. Rodrigues, S. Saba, A. C Joussef, J. Rafique, A. L. Braga. KIO3-catalyzed C(sp2)-H bond selenylation/sulfenylation of (hetero)arenes: synthesis of chalcogenated (hetero)arenes and their evaluation for anti-Alzheimer activity.. Asian Journal of Organic Chemistry, v. 7, p. 1819-1824, 2018, 2018.

7. S. Saba, J. Rafique, M. S. Franco, A. R. Schneider, L. Espindola, D. Silva, A. L. Braga. Rose Bengal Catalyzed Photo-Induced Selenylation of Indoles, Imidazoles and Arenes: A Metal Free Approach. Organic & Biomolecular Chemistry, v. 16, p. 880-885, 2018.

8. Y. H. Matzkeit, B. L. Tornquist, F. Manarin, G. V. Botteselle, J. Rafique, S. Saba, A. L. Braga, J. F. Felix, Ricardo Schneider. Borophosphate glasses: Synthesis, characterization and application as catalyst for bis(indolyl)methanes synthesis under greener conditions. Journal of Non-Crystalline Solids, v. 498, p. 153-159, 2018.

9. L. Bettanin, S. Saba, C. V.Doerner. M. S.Franco, M. Godoi, J. Rafique, A. L.Braga. NH4I-catalyzed chalcogen(S/Se)-functionalization of 5-membered N-heteroaryls under metal-free conditions, Tetrahedron, v. 47, p. 3971–3980, 2018.

10. A. G. Dal-Bó, R. C. Duarte, R. Cercená, M. Peterson, J. Rafique, S. Saba, E. Zapp, E. S. Gil, P. F.B. Gonçalves, F. S. Rodembusch, T. E. A. Frizon. New long-chain donor-acceptor-donor pyromellitic diimide (PMDI) derivatives. A combined theoretical and experimental study. Dyes and Pigments, v. 157, p. 143-150, 2018.

11. B. L. Tornquist, G. de. P. Bueno, J. C. M. Willig, I. M. de Oliveira, H. A. Stefani, J. Rafique, S. Saba, B. A. Iglesias, G. V. Botteselle, F. Manarin. Ytterbium (III) triflate/Sodium Dodecyl Sulfate: A Versatile Recyclable and Water-Tolerant Catalyst for the Synthesis of Bis(indolyl)methanes (BIMs). ChemistrySelect, v. 3, p. 6358-6363, 2018.

12. M. M. Peterle, M. R. Scheide, L. T. Silva, S. Saba, J. Rafique, Antonio L. Braga. Copper‐Catalyzed Three‐Component Reaction of Oxadiazoles, Elemental Se/S and Aryl Iodides: Synthesis of Chalcogenyl (Se/S)‐Oxadiazoles. ChemistrySelect, v. 3, p. 13191-13196, 2018.

13. J. C. M. Willig, A. A. Amaral, J. Rafique, S. Saba, S. Valiati, I. M. Oliveira, H. A. Stefani, F. Manarin, F, G. V. Botteselle. Synthesis of Bis(indolyl)methanes Using Fe3O4 Nanoparticle as a Robust, Efficient and Magnetically Recoverable Catalyst Under Solvent-Free Conditions. Revista Virtual de Química, v. 10, p. 1591-1606, 2018.

14. J. Rafique, S. Saba, T. E. A. Frizon, A. L. Braga. Fe O Nanoparticles: A Robust and Magnetically Recoverable Catalyst for Direct C-H Bond Selenylation and Sulfenylation of Benzothiazoles. ChemistrySelect, v. 3, p. 328-334, 2018.

15. S. Saba, G. Botteselle, M. Godoi, T. E. A. Frizon, F. Galetto, J. Rafique, A. L. Braga. Copper-Catalyzed Synthesis of Unsymmetrical Diorganyl Chalcogenides (Te/Se/S) from Boronic Acids under Solvent-Free Conditions. Molecules, v. 22, p. 1367, 2017.

16. L. Bettanin, S. Saba, F. Z. Galetto, G. A. Mike, J. Rafique A. L. Braga. Solvent- and metal-free selective oxidation of thiols to disulfides using I2 /DMSO catalytic system. Tetrahedron Letters, v. 58, p. 4713-4716, 2017.

17. L. T. Silva, J. B. Azeredo, S. Saba, J. Rafique, A. J. Bortoluzzi, and A. L. Braga, Solvent- and metal-free chalcogenation of bicyclic arenes using I2/DMSO as non-metallic catalytic system, European Journal of Organic Chemistry, v. 2017, p. 4740–4748, 2017.

18. J. Rafique, S. Saba, A. R. Schneider, M. S. Franco, S. M. Silva, and A. L. Braga, Metal- and Solvent-Free Approach to Access 3‑Se/S-Chromones from the Cyclization of Enaminones in the Presence of Dichalcogenid Catalyzed by KIO3, ACS Omega, v. 2, p. 2280–2290, 2017.

19. M. S. T. Rocha, J. Rafique, S. Saba, J. B. Azeredo, D. Back, M. Godoi, A. L. Braga, Stereoselective Hydrothiolation of Terminal Acetylene catalyzed by Magnetite (Fe3O4) Nanoparticles, Synthetic Communications, v.47, p. 291-298, 2017.

20. F. A. R. Barbosa, R. F. S. Canto, S. Saba, J. Rafique, A. L. Braga, Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multitargeted directed compounds against Alzheimer’s disease, Bioorganic and Medicinal Chemistry, v. 24, p. 5762–5770, 2016.

21. J. Rafique, S. Saba, and A. R. Rosário, and A. L. Braga, Regioselective, solvent- and metal-free chalcogenation of imidazo[1,2-a]pyridines employing I2/DMSO as an eco-friendly catalytic oxidation system, Chemistry - A European Journal, v. 22, p. 1-10, 2016. Hot Paper

22. S. Saba, J. Rafique and A. L. Braga, DMSO/Iodine-Catalyzed Oxidative C–Se/C–S Bond Formation: A Regioselective Synthesis of Unsymmetrical Chalcogenides with Nitrogen- or Oxygen-containing Arenes, Catalysis Science & Technology, v. 6, p. 3087-3098, 2016.

23. H. Khan, H. Amin, A. Ullah, S. Saba, J. Rafique, K. Khan, N. Ahmad and S. L. Badshah, Antioxidant and antiplasmodial activities of bergenin and 11-O-galloylbergenin isolated from Mallotus philippinensis, Oxidative Medicine and Cellular Longevity, v. 2016, p. 1-6, 2016.

24. A. G. D. Bó, Y. M. S. Micheletto, F. C. Giacomelli, G. Lopez, M. J. R. Sartor, J. Rafique, S. Saba, L. D. M. D. Silveira, J. Mendes and T. E. A. Frizon, Synthesis of new monodendrons, gallic acid derivatives, selfassembled in a columnar phase. Liquid Crystals, v. 43, p. 292-304, 2016. Selected for the Cover page of Journal Liquid Crystals

25. J. Rafique, R. F. S. Canto, S. Saba, F. A. R. Barbosa and A. L. Braga, Recent advances in the synthesis of biologically relevant selenium containing 5-member heterocycles, Current Organic Chemistry, v. 20, p. 166-188, 2016.

26. M. Arfan, R. Khan, A. Tavman and S. Saba, Spectral characterization and crystal structure of 2-amino-N′-[(1Z)-1-(4-chlorophenyl)ethylidene]-benzohydrazide. Journal of Saudi Chemical Society, v. 20, p. 40-44, 2016.

27. J. Rafique, S. Saba, R. F. S. Canto, T. E. A. Frizon, W. Hassan, E. P. Waczuk, M. Jan, D. F. Back, J. B. T. D. Rocha and A. L. Braga, Synthesis and Biological Evaluation of 2-Picolylamide-Based Diselenides with Non-Bonded Interactions. Molecules, v. 20, p. 10095-10109, 2015.

28. S. Saba, J. Rafique and A. L. Braga, Synthesis of Unsymmetrical Diorganyl Chalcogenides under Greener Conditions: Use of a Catalytic Iodine/DMSO Oxidant System, Solvent- and Metal-Free Approach. Advanced Synthesis & Catalysis, v. 357, p. 1446-1452, 2015.

29. T. E. Frizon, J. Rafique, S. Saba, I. H. Bechtold, H. Gallardo and A. L. Braga, Synthesis of new functionalized organoselenium materials: selenides and diselenides containing cholesterol. European Journal of Organic Chemistry, v. 2015, p. 3470-3476, 2015.

30. G. Abbas, M. Shahzad, Z. Saddiqe, M. J. Hassan, S. Saba, J. Rafique, R. Malik and H. Hussain, Various fractions of Hypericum x moserianum and Hypericum ericoides possess antiglycation, anti-lipid peroxidation, antioxidative activities and non-toxic effects in vitro. Pakistan journal of pharmaceutical sciences, v. 28, p. 933-98, 2015.

31. J. Rafique, S. Saba, A. R. Rosário, G. Zeni and A. L. Braga, K2CO3-mediated, direct C–H bond selenation and thiolation of 1,3,4-oxadiazoles in the absence of metal catalyst: an eco-friendly approach. RSC Advances, v. 4, p. 51648-51652, 2014.

32. M. Arfan, M. N. Tahir, R. Khan, S. Saba and M. S. Iqbal, (2-Aminophenyl)[(5S)-5-hydroxy-3,5-dimethyl-4,5-dihydro-1H-pyrazol-1-yl]methanone. Acta Crystallographica Section E, E65, o1834-o1835, 2009. [ doi:10.1107/S1600536809026294 ].

Patents:
1. S. Saba, Diselenide derivatives of 2-picolylamine and process of their obtaining, BR-10-2013-010963-0 A2, Publication date: 26/05/2015.

2. S. Saba, Process of production of diselenide derivatives of esters: compounds obtained, and the use of compounds (synthesis and application) as antioxidants and Glutathione Peroxidase Enzyme (GPX) mimetics, BR-10-2014-021458-5 A2, Publication date: 26/04/2016.

3. S. Saba, Process for the preparation of selenoesters derivatives of Dihydropyrimidinone and its application as antioxidants and as inhibitors of acetylcholinesterase in the treatment of Alzheimer disease, BR 10 2017 007303 3, 2017.




Current profession

Current professional activities type: 
Research
Higher Education Study
Assistant Professor of Chemistry Post-doc Ph.D. researcher

Affiliations

American Chemical Society - ACS
National Academy of Young Scientists (NAYS)

Presentation given

Event:
Event:
Prizes, Grants and Awards

TWAS Awards

Mar 2012
Fellowship
TWAS-CNPq PhD research program

Other Awards

Jul 2019
ACS Summer School on Green Chemistry & Sustainable Energy”, Colorado School of Mines Golden, Colorado
One of the two selected candidates from Brazil for attending fully funded “ACS Summer School on Green Chemistry & Sustainable Energy”, Colorado School of Mines Golden, Colorado
May 2018
Research Productivity Award 2017-2018, Pakistan Council for Science and Technology (PCST)
May 2018
Pakistan Productive Scientists Award, Pakistan Council for Science and Technology (PCST)
Jan 2017
HEC Approved PhD Supervisor
Nov 2016
Technology Award in Invention to Innovation Summit 2016, UET, Peshawar University
Nov 2016
SRC Awards for Innovative Chemistry Research (20,000 PKR), in Invention to Innovation Summit 2016, UET, Peshawar University
Apr 2016
Awarded to attend the TWAS/BioVisionAlexandria.NXT 2016 conference, Alexandria, Egypt (10-11, April 2016) and the BioVisionAlexandria 2016 conference
Jun 2014
Awarded to attend the BIOVISION.Next Fellowship Programme at BIOVISION 2014 - the World Life Sciences Forum, Lyon, France
May 2010
Awardee of National Internship Programme (NIP) as a Research Fellow in HEJ, Research institute of Chemistry
Feb 2020
“World Forum for Women in Science-2020”, Brazilian Academy of Sciences, Rio de Janeiro
Invited Speaker in “World Forum for Women in Science-2020”, Organized by the Brazilian Academy of Sciences, Rio de Janeiro, Brazil.
EB Role

Candidate Vice-President

Candidate
Vice-President
Latin America & Caribbean 2021 to 2025

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