Member Profile
Membership type: full
Muniza Shaikh
Country of origin: Pakistan Currently in: Pakistan, Karachi General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2019 Doctorate Structural, Cell and Molecular Biology -
Current Research Activities
Structural, Cell and Molecular Biology
Field of Training: Structural Biology Institution: Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi. Studied protein-ligand interactions of therapeutically important enzymes using in silico designing of inhibitors, molecular docking, MD simulation studies and STD-NMR techniques. She has been trained on the NMR Spectroscopic evaluation of kinetic parameters of therapeutically important enzymes via progress curve analysis, and estimation of binding epitope and affinity of ligands by saturation transfer difference (STD) NMR spectroscopy.
Publications resulting from Research:
• Javaid, S., Ishtiaq, M., Shaikh, M., Hameed, A., & Choudhary, M. I. (2017). Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro. Bioorganic Chemistry, 70, 44-56.
• Khan, J. A., Javaid, S., Maryam, A. G., Huwait, E., Shaikh, M., Shafqat, A., & Choudhary, M. I. Studies on new urease inhibitors by using biochemical, STD-NMR spectroscopy, and molecular docking methods. Medicinal Chemistry Research, 1-16.
• Khan, M., Khan, K. M., Parveen, S., Shaikh, M., Fatima, N., & Choudhary, M. I. (2019). Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies. Bioorganic Chemistry, 83, 595-610.
• Shaikh, M., Siddiqui, S., Zafar, H., Naqeeb, U., Subzwari, F., Imad, R., & Choudhary, M. I. (2019). Antiglycation activity of triazole Schiff's bases against fructose-mediated glycation: In vitro and in silico study. Medicinal chemistry (Shariqah (United Arab Emirates)).
• Javaid, S., Shaikh, M., Fatima, N., & Choudhary, M. I. (2019). Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies. PloS one, 14(11), e0225056.
Current profession
Current professional activities type:Research
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Other Awards
Dec 2011Syed Abid Ali Zaidi Gold MedalFor Securing First class first Position in M.Sc. Biochemistry
