Shabana Usman Simjee SimjeeCountry of origin: Pakistan Currently in: Pakistan, Karachi General field of specialization: Medical and Health Sciences incl Neurosciences
Degrees2001 Doctorate Medical and Health Sciences incl Neurosciences1997 Master Medical and Health Sciences incl Neurosciences1991 Master Medical and Health Sciences incl Neurosciences1990 Undergraduate Medical and Health Sciences incl Neurosciences
Current Research Activities
Medical and Health Sciences incl Neurosciences
Research focus is in the area of chronic pain, epilepsy, and tumors. Currently, my team interest is in testing novel pharmacotherapeutics including targeted / nanotherapeutics for tumor and epilepsy. In addition, the research interest of the group is also focused on molecular mechanisms of neurogenesis in adult brain, with an emphasis on the hippocampal region and neocortex. This will aid in the conceptual understanding of brain function and structural plasticity and in development of novel approaches to restore brain function in disease states
Publications resulting from Research:
Hanif F, Perveen K, Malhi SM, Jawed H, Simjee SU. (2018), Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 52: 306-313.
Shaheen F, Nadeem-Ul-Haque M, Ahmed A, Simjee SU, Ganesan A, Jabeen A, Shah ZA, Choudhary MI. (2018), Synthesis of breast cancer targeting conjugate of temporin-SHa analog and its effect on pro- and anti-apoptotic protein expression in MCF-7 cells. Peptides 106: 68-82.
Siddiqui RA, Simjee SU, Kabir N, Ateeq M, Shah MR, Hussain SS. (2018), N-(2-hydroxyphenyl)acetamide and its gold nanoparticle conjugation prevent glycerol-induced acute kidney injury by attenuating inflammation and oxidative injury in mice. Mol Cell Biochem doi: 10.1007/s11010-018-3371-3.
Gul A, Kunwar B, Mazhar M, Faizi S, Ahmed D, Shah MR, Simjee SU. (2018), Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-κB and iNOS activation. Int Immunopharmacol. 59:310-317.
Hussain SS, Rafi K, Faizi S, Razzak ZA, Simjee SU. (2018), A novel, semi-synthetic diterpenoid 16(R and S)-phenylamino-cleroda-3,13(14), Z-dien-15,16 olide (PGEA-AN) inhibits the growth and cell survival of human neuroblastoma cell line SH-SY5Y by modulating P53 pathway. Mol Cell Biochem. doi: 10.1007/s11010-018-3347-3.
Mbiantcha Marius, Almas Jabeen, Ateufack Gilbert, Shabana U. Simjee, Bomba Tatsinkou, Francis Desire, Nida Dastagir (2018), NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum (Mimosaceae) on rats. Asian Pacific Journal of Tropical Biomedicine 8(3): 150-59.
Gul A, Kunwar B, Mazhar M, Perveen K, Simjee SU, (2017), N-(2-Hydroxyphenyl) acetamide: A novel suppressor of RANK/RANKL pathway in collagen-induced arthritis model in rats. Inflammation, 40(4):1177- 1190.
Hasan F., Najam R., Simjee SU. (2017), Metformin-A non-conventional drug for the local treatment of periodontal diseases: A randomized clinical control study. Med. Forum 28(6): 162-166.
Mazhar M, Faizi S, Gul A, Kabir N, Simjee SU, (2017), Effects of naturally occurring flavonoids on ferroportin expression in the spleen in iron deficiency anemia in vivo, RSC Adv., 7: 23238.
Mbiantcha M, Almas J, Simjee SU, Nida D, Aisha F, (2017), Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats, BMC Complement Altern Med, 17:111.
Hanif F, Muzaffar K, Perveen K, Malhi SM, Simjee SU (2017), Glioblastoma Multiforme: A Review of its Epidemiology and Pathogenesis through Clinical Presentation and Treatment. Asian Pac J Cancer Prev, 18(1): 3-9.
Mazhar F, Malhi SM, Simjee SU (2017), Comparative studies on the effects of clinically used anticonvulsants on the oxidative stress biomarkers in pentylenetetrazole-induced kindling model of epileptogenesis in mice. J Basic Clin Physiol Pharmacol. 28(1): 31-42.
Itefaq Hussain Qureshi, Shabana Usman Simjee (2016), Effects of combined regimens of gabapentin and verapamil with diazepam on kindled model of epilepsy in mice
J Bahria Uni Med Dental Coll ;6(1):18-22.
Zafar Ali Shah, Attiya Hameed, Aqeel Ahmed, Shabana U. Simjee, Almas Jabeen, Abid Ullah, Farzana Shaheen (2016) Cytotoxic and anti-inflammatory salicin glycosides from leaves of Salix acmophylla. Phytochem Lett 17: 107-113.
Jabeen A, Mesaik MA, Simjee SU, Lubna, Bano S, Faizi S (2016), Anti-TNF-α and anti-arthritic effect of patuletin: A rare flavonoid from Tagetes patula. Int Immunopharmacol. 36:232-40.
Shaheen F, Ziaee MA, Ali SA, Simjee SU, Ahmed A, Choudhary MI (2016), The First Solid-phase Synthesis and Structural Studies on Phakellistatin 15. Rec. Nat. Prod. 10: 397-406.
Rehan Ahmed Siddiqui, Nurul Kabir, M. Ateeq, Shabana U. Simjee, M. Raza Shah. (2016) Characterizing kidney structures in health and diseases using eosin fluorescence from hematoxylin and eosin stained sections. J Histotech, 39(4): 107-115.
Simjee SU, Perveen H, Zehra SQ, Ayub A, Siddiqui BS, Begum S (2016), Suppression of Thermal and Chemical Nociception in Rats by Methanol Extract and its Sub-Fractions from Lantana camara. J.Chem.Soc.Pak. 38(4): 685-692.
R Farheen, BS Siddiqui, I Mahmood, SU Simjee, S Majeed (2016), GC, GC-MS Analysis of Lipophilic Fractions of Aerial Parts of Fagonia indica Burm. f. Showing Growth Inhibitory Effect on HT 29 Colorectal Cancer Cells. J. Chem Soc Pak. 38 (4): 717.
Farheena R, Siddiqui BS, Mahmooda I, Simjee SU, Majeed S. (2015). Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm. Phytochem Letters 13: 256–261.
Hanif F, Perveen K, Jawed H, Ahmed A, Malhi SM, Jamall S, Simjee SU. (2014). N-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87. Cancer Cell International 14: 133.
Perveen K, Hanif F, Jawed H, Jamall S, Simjee SU. (2014). N-(2-hydroxy phenyl) acetamide: A novel suppressor of Toll like receptors (TLR2 and TLR4) in adjuvant-induce arthritic rats. Mol Cell Biochem. 394(1-2): 67-75.
Saeed Arayne M, Sultana N, Khan MM, Simjee SU (2014) Leflunomide with meloxicam on progression of rheumatoid arthritis and its associated depression in AIA rats. Clinic Pharmacol Biopharmaceut 3:114. doi: 10.4172/2167-065X.1000114.
Jawed H, Jamall S, Shah SUA, Perveen K, Hanif F, Simjee SU. (2014). N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats. Mol Cell Biochem. 387(1): 81-90
Malhi SM, Jawed H, Hanif F, Ashraf N, Farhat Z, Siddiqui BS, Begum S, Kabir N, Simjee SU. (2014). Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel anti-epileptic compound HHL-6. BioMed Res Int. vol 2014: Article ID 876712.
Ashraf MN, Gavrilovici C, Ali Shah SU, Shaheen F, Choudhary MI, Rahman AU, Fahnestock M, Simjee SU, Poulter MO. (2013). A novel anticonvulsant modulates voltage-gated sodium channel inactivation and prevents kindling-induced seizures. J. Neurochem 126(5): 651-61.
Perveen K, Hanif F, Jawed H, Simjee SU. (2013). Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats. BioMed Res. Int. Volume 2013 (2013), Article ID 635143, http://dx.doi.org/10.1155/2013/635143.
Shah SUA, Jawed H., Awan SI, Anjum S, Simjee SU. (2013). The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis. BioMed Res. Intl. Volume 2013 (2013), Article ID 487610, http://dx.doi.org/10.1155/2013/487610
Hanif F, Perveen K, Jawed H, Simjee SU. (2013). In vitro growth inhibition of U87 glioblastoma cells by N-(2- hydroxyphenyl) acetamide. Intl. J Med & Pharm Sci. (IJMPS) Vol 3(4), 69-78
Shah SU, Ashraf N, Soomro ZH, Shah MR, Kabir N, Simjee SU. (2012). The anti-arthritic and anti-oxidative effect of NBD (6-nitro-1,3-benzodioxane) in adjuvant induced arthritis (AIA) in rats. Inflammation Res. 61(8):875-87.
Simjee SU, Shaheen F, Choudhary MI, Rahman AU, Jamall S, Shah SU, Khan N, Kabir N, Ashraf N. (2012). Suppression of c-Fos Protein and mRNA Expression in Pentylenetetrazole-Induced Kindled Mouse Brain by Isoxylitones. J Mol Neurosci. 47(3): 559-570.
Jawed H, Anjum S, Awan SI, Simjee SU (2011). Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats. Inflamm. Res. 60(12):1113-20.
Jawed H, Shah SUA, Jamall S, Simjee SU (2010). N-(2-hydroxy phenyl) acetamide inhibits inflammation-related cytokines and ROS in adjuvant-induced arthritic (AIA) rats. Intl. Immunopharmacol. 10(8):900-5.
Raza ML, Zeeshan Mohammad, Manzoor A, Farzana S, Simjee SU. (2010). Anticonvulsant activity of DNS II fraction in the acute seizure models. J Ethnopharmacol. 128(3): 600-605.
Ahmad S, Ashraf N, Nisar-ur-Rehman, Nazir M, Ashraf S, Akhtar KS, Muhammad Saleem, Riaz N, Jabbar A, Simjee SU. (2010), Anticonvulsant and antimicrobial activities of the methanolic extract of Cymbopogon jwarancusa. J. Trop. Med. Plants 11(1): 39-44.
Khan S, Nisar M, Simjee SU, Rehman W, Khan R, Jan I, Momin D-S. (2010). Evaluation of micronutrients level and antinociceptive property of Eremostachys laciniata (L) Bunge. African J Biotech. 9(5): 775-777.
Gul A, Rahman MA, Salim A, Simjee SU. (2009). Advanced glycation end products in senile diabetic and nondiabetic patients with cataract. J Diabetes Complications 23 (5): 343-348.
Gul A, Rahman MA, Salim A, Simjee SU. (2008) Advanced glycation end products in senile diabetic and non-diabetic patients with cardiovascular complications. AGE 30(4):303-9.
Gul A, Rahman MA, Hasnain SN, Salim A, Simjee SU (2008). Could Oxidative Stress Associate with Age-Products in Cataractogenesis? Current Eye Research, 33: 669-675.
Nisar M, Khan I, Simjee SU, Gilani AH, Obaidullah, Perveen H. (2008). Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc. J Ethnopharmacol. 116(3):490-494.
Simjee SU, Jawed H, Quadri J, Saeed SA. (2007). Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease modifying anti-rheumatoid drugs in the adjuvant induced arthritic rat. Arthritis Research & Therapy 9(5):R91.
Saeed SA, Shad KF, Simjee SU (2007). Dual inhibition of cycloxygenase and lipoxygenase enzymes by human cerebrospinal fluid. Exp Brain Res. Apr; 178(4): 560-4.
Merly L., Simjee S., Smith SL. (2007). Induction of inflammatory cytokines by cartilage extracts. Int. Immunopharmacol. 7(3): 383-391.
M. Kamran Azim, Humera Perveen, M. Ahmed Mesaik and Shabana U. Simjee (2007). Anti-nociceptive activity of natural honey in thermal-nociception models in mice. Phytother. Res. 21(2): 194-197.
Sheikh Arshad Saeed, Shumaila Tasneem, Nazia Qidwai and Shabana Usman Simjee (2005). Low dose aspirin depresses human platelets aggregation triggered by activating agents whose mechanisms involve arachidonic acid. JCPSP 15(10): 665.
Sheikh Arshad Saeed, Imran Manzoor, Javeria Quadri, Shumaila Tasneem and Shabana Usman Simjee (2005). Demystifying Phytochemicals: An Insight. Intl. J. Pharmacol. 1(3): 234-238.
Shabana Simjee, Barbara Pleuvry, Paul Coulthard (2004). Modulation of the gait deficits in arthritic rats by infusions of muscimol and bicuculline. Pain, 109(3): 453-460
Coulthard P, Simjee SU, Pleuvry BJ. (2003). Gait analysis as a correlate of pain induced by carrageenan intraplantar injection. J Neuroscience Methods, 128(1-2): 95-102.