Member Profile
Membership type: full
Feven Tigistu-Sahle
Country of origin: Ethiopia Currently in: Ethiopia, Addis Ababa General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2017 Doctorate Structural, Cell and Molecular Biology2012 Master Structural, Cell and Molecular Biology2005 Undergraduate Structural, Cell and Molecular Biology -
Current Research Activities
Biological Systems and Organisms
Health Biotechnology, Development of Diagnostic tools for communicable and non-communicable diseases.
Publications resulting from Research:
1. Laurén, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajärvi, A., Eronen, J., Siljander, P., Pettilä, V., Käkelä, R., Laitinen, S., Kerkelä, E., 2017. Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 1863 (1), pp. 1-8.
2. Hellwing, C., Tigistu‐Sahle, F., Fuhrmann, H., Käkelä, R. and Schumann, J., 2017. Lipid composition of membrane microdomains isolated detergent‐free from PUFA supplemented RAW264. 7 macrophages. Journal of Cellular Physiology.
3. Tigistu-Sahle, F., Lampinen, M., Kilpinen, L., Holopainen, M., Lehenkari, P., Laitinen, S. and Käkelä, R., 2017. Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells. Journal of Lipid Research, 58(1), pp.92–110.
4. Robciuc, M.R., Kivelä, R., Williams, I.M., de Boer, J.F., van Dijk, T.H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppänen, V.M., Käkelä, R. and Eklund, L., 2016. VEGFB/VEGFR1-induced expansion of adipose vasculature counteracts obesity and related metabolic complications. Cell metabolism, 23(4), pp.712-724.
5. Mäenpää, K., Leppänen, M.T., Figueiredo, K., Tigistu-Sahle, F. and Käkelä, R., 2015. Sorptive capacity of membrane lipids, storage lipids, and proteins: A preliminary study of partitioning of organochlorines in lean fish from a PCB-contaminated freshwater lake. Archives of Environmental Contamination and Toxicology, 68(1), pp.193-203.
6. Kilpinen, L. *, Tigistu-Sahle, F. *, Oja, S., Greco, D., Parmar, A., Saavalainen, P., Nikkilä, J., Korhonen, M., Lehenkari, P., Käkelä, R. and Laitinen, S., 2013. Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. Journal of Lipid Research, 54(3), pp.622–635.
7. Tigistu-Sahle F. *, Holopainen, M.*, Skirdenko, V., Hyvärinen, Kerkelä, E., Lehenkari, P., Laitinen, S. and Käkelä, R., 2017. Dynamics of incorporation of n-6 and n-3 polyunsaturated fatty acids into the glycerophospholipids of human bone marrow derived mesenchymal stromal cells. (manuscript)
Current profession
Current professional activities type:ResearchAs part of the Diagnostic Tool development team, we focus in analyzing and designing biotechnological techniques and biomarkers for identifying or staging various communicable diseases relevant to the Sub-sahran region.
Workshop and Conference Attended
2013 University of Helsinki, Finland ‘‘Lipid signaling: lipid derived 2nd messengers’’: Functional Lipidomics Seminar.2014 Tekes IMO Programme summit - Helsinki, Finland ‘‘Fatty acid metabolism of mesenchymal stem cells, Membranes and Receptors research network seminar’’.2012 University of Helsinki, Finland “Lipid markers & functionality of aging human bone marrow mesenchymal stem cells’’2013 San Juan, Puerto Rico ‘‘13th International Conference on Bioactive lipids in Cancer, Inflammation and Related Diseases’’.2012 Spestes, Greece “Aging bone marrow derived mesenchymal stromal cells have altered membrane lipid composition and functionality’’ FEBS SeminarAffiliations
University of HelsinkiPresentation given
2016“Metabolism of polyunsaturated fatty acids in human mesenchymal stromal cells’’Helsinki, FinlandEvent: Finnish National Lipid Forum2013Bioactive lipid mediatorsSan Juan, Puerto RicoEvent: ‘‘13th International Conference on Bioactive lipids in Cancer, Inflammation and Related Diseases’’.2013“Aging bone marrow derived mesenchymal stromal cells have altered membrane lipid composition and functionality’’Spestes, GreeceEvent: FEBS Seminar2012“Lipid markers & functionality of aging human bone marrow mesenchymal stem cells’’Helsinki, FinlandEvent: MEMBREC Seminar2014‘‘Fatty acid metabolism of mesenchymal stem cells, Membranes and Receptors research network seminar’’.Espoo, FinlandEvent: Tekes IMO Programme summit and reporting seminars.
