Member Profile
Patricia Talamás-Rohana
Country of origin: Mexico Currently in: Mexico, Ciudad de México General field of specialization: Structural, Cell and Molecular Biology- Academic Background
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Degrees
1987 Doctorate Structural, Cell and Molecular Biology - Research and Profession
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Current Research Activities
Structural, Cell and Molecular Biology
As to the year 2020, I am working on various lines of research. Since for almost 20 years I worked mainly on aspects of cell biology and immunology of protozoan parasites, particularly Entamoeba histolytica / dispar and Leishmania mexicana. With E. histolytica I continue to study aspects of vesicular transport, specifically the role of EhRab21 and its relevance in pathogenic mechanisms. With L. mexicana we recently published an article in which we demonstrate that the 63 kDa glycoprotein (gp63) is responsible for presenting the activity of cyclooxygenase-2 (COX-2), the enzyme responsible for the production of prostaglandin E2 (PGE2). This is an important finding because this enzymatic activity can modulates the host’s immune response. Currently, we are studying the mechanisms by which this activity can modulate the host's immune response. To date, most of the projects in my laboratory are aimed at the study of Ovarian Cancer. In 2009, I began a transition towards the study of this pathology, by establishing a collaboration agreement with the National Cancer Institute, particularly with the Ovarian Cancer Group led by Dr. Dolores Gallardo-Rincón, through which, through out these years we have received support for obtaining patient samples, as well as the advice from Dr. Gallardo in the tutoring committees of my students. The projects in Ovarian Cancer are the following: - Participation of the PHF20L1 protein, a transcriptional regulator, in the progression of the epithelial ovarian cancer. - Characterization of fucosyltransferase 4 in cells exposed to ascitic fluid and its participation in the progression of ovarian cancer. - Phenotypic and functional characterization of T lymphocytes in a murine model of ovarian cancer. - Characterization of innate lymphoid cells and their role in tumor development in a murine model of ovarian cancer. Likewise, in collaboration with Dr. Arturo Vera of the Bioelectronics Section of the Engineering Department, we are working on a project aimed at seeking an improvement in the treatment of breast cancer through electrochemotherapy. The project in question is entitled “Evaluation of electrochemotherapy as a potential first-line treatment for primary invasive ductal carcinoma of the breast through the establishment of in vitro electroporation protocols and its transfer to an in vivo model”.
Publications resulting from Research:
1: Montaño S, Constantino-Jonapa LA, Sixto-López Y, Hernández-Ramírez VI,
Hernández-Ceruelos A, Romero-Quezada LC, Ruvalcaba-Ledezma JC, Talamás-Rohana P,
López-Contreras L. Vorinostat, a possible alternative to metronidazole for the
treatment of amebiasis caused by Entamoeba histolytica. J Biomol Struct Dyn. 2020
Feb;38(2):597-603. doi: 10.1080/07391102.2019.1578693. Epub 2019 Apr 26. PubMed
PMID: 30744531.
2: Alberto-Aguilar DR, Hernández-Ramírez VI, Osorio-Trujillo JC, Gallardo-Rincón
D, Toledo-Leyva A, Talamás-Rohana P. Ascites from Ovarian Cancer Induces Novel
Fucosylated Proteins. Cancer Microenviron. 2019 Dec;12(2-3):181-195. doi:
10.1007/s12307-019-00227-z. Epub 2019 Jul 2. PubMed PMID: 31267484; PubMed
Central PMCID: PMC6937354.
3: Varela-Rodríguez L, Sánchez-Ramírez B, Rodríguez-Reyna IS, Ordaz-Ortiz JJ,
Chávez-Flores D, Salas-Muñoz E, Osorio-Trujillo JC, Ramos-Martínez E,
Talamás-Rohana P. Biological and toxicological evaluation of Rhus trilobata Nutt.
(Anacardiaceae) used traditionally in Mexico against cancer. BMC Complement
Altern Med. 2019 Jul 1;19(1):153. doi: 10.1186/s12906-019-2566-9. PubMed PMID:
31262287; PubMed Central PMCID: PMC6604276.
4: Pulido-Ortega J, Talamás-Rohana P, Muñoz-Ortega MH, Aldaba-Muruato LR,
Martínez-Hernández SL, Campos-Esparza MDR, Cervantes-García D, Leon-Coria A,
Moreau F, Chadee K, Ventura-Juárez J. Functional Characterization of an
Interferon Gamma Receptor-Like Protein on Entamoeba histolytica. Infect Immun.
2019 Oct 18;87(11). pii: e00540-19. doi: 10.1128/IAI.00540-19. Print 2019 Nov.
PubMed PMID: 31427448; PubMed Central PMCID: PMC6803330.
5: Constantino-Jonapa LA, Hernández-Ramírez VI, Osorio-Trujillo C, Talamás-Rohana
P. EhRab21 mobilization during erythrophagocytosis in Entamoeba histolytica.
Microsc Res Tech. 2018 Sep;81(9):1024-1035. doi: 10.1002/jemt.23069. Epub 2018
Sep 20. PubMed PMID: 30238543.
6: Estrada-Figueroa LA, Díaz-Gandarilla JA, Hernández-Ramírez VI,
Arrieta-González MM, Osorio-Trujillo C, Rosales-Encina JL, Toledo-Leyva A,
Talamás-Rohana P. Leishmania mexicana gp63 is the enzyme responsible for
cyclooxygenase (COX) activity in this parasitic protozoa. Biochimie. 2018
Aug;151:73-84. doi: 10.1016/j.biochi.2018.05.016. Epub 2018 Jun 2. PubMed PMID:
29864507.
7: Toledo-Leyva A, Villegas-Pineda JC, Encarnación-Guevara S, Gallardo-Rincón D,
Talamás-Rohana P. Effect of ovarian cancer ascites on SKOV-3 cells proteome: new
proteins associated with aggressive phenotype in epithelial ovarian cancer.
Proteome Sci. 2018 Feb 13;16:3. doi: 10.1186/s12953-018-0133-9. eCollection 2018.
PubMed PMID: 29456457; PubMed Central PMCID: PMC5810116.
8: Herrera-Martínez M, Hernández-Ramírez VI, Hernández-Carlos B, Chávez-Munguía
B, Calderón-Oropeza MA, Talamás-Rohana P. Antiamoebic Activity of Adenophyllum
aurantium (L.) Strother and Its Effect on the Actin Cytoskeleton of Entamoeba
histolytica. Front Pharmacol. 2016 Jun 27;7:169. doi: 10.3389/fphar.2016.00169.
9: Villegas-Pineda JC, Garibay-Cerdenares OL, Hernández-Ramírez VI,
Gallardo-Rincón D, Cantú de León D, Pérez-Montiel-Gómez MD, Talamás-Rohana P.
Integrins and haptoglobin: Molecules overexpressed in ovarian cancer. Pathol Res
Pract. 2015 Dec;211(12):973-81. doi: 10.1016/j.prp.2015.10.002. Epub 2015 Nov 6.
PubMed PMID: 26549463.
Current profession
At this moment I am at the Infectomics and Molecular Pahtogenesis Department at "Centro de Investigación y de Estudios Avanzados del IPN" (CINVESTAV, for short). I am a professor and have a research laboratory where I am the advisor of 5 Ph.D. students, two research technicians, and thres visiting students (social service from a B.Sc. program and from a M.Sc. program). I also participate giving some lectures during the courses for our M.Sc. students.
Affiliations
Mexican Society of Cell BiologyMexican Society of Biochemistry
