Member Profile
Membership type: full
Celia Quijano
Country of origin: Uruguay Currently in: Uruguay, Montevideo General field of specialization: Structural, Cell and Molecular Biology-
Degrees
Chemical Sciences -
Current Research Activities
Structural, Cell and Molecular Biology
Metabolic alterations in cell senescence
Publications resulting from Research:
Demicheli V, Moreno D, Jara G, Lima A, Carballal S, Rios N, Batthyany C, Ferrer- Sueta G, Quijano C, Estrín D, Martí M, Radi R. Mechanism of the Reaction of human Mn-Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine-34. Biochemistry, 2016. [Epub ahead of print].
Quijano C, Trujillo M, Castro L, Trostchansky A. Interplay between oxidant species and energy metabolism. Redox Biol. 2016; 8:28-42.
Martino Adami PV, Quijano C, Magnani N, Galeano P, Evelson P, Cassina A, Do Carmo S, Leal MC, Castaño EM, Cuello AC, Morelli L. Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease. J Cereb Blood Flow Metab. 2015 [Epub ahead of print]
Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle. 2012; 11(7):1383-92.
Valez V, Aicardo A, Cassina A, Quijano C, Radi R. Oxidative Stress in Mitochondria Principles of Free Radical Biomedicine. Editors: K. Pantopoulos and H. Schipper. Nova Science Publishers Inc. 2012; 2:283 – 302.
Yadav H, Quijano C, Kamaraju KA, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, and Rane SG. Protection from Obesity and Diabetes by Blockade of TGF-b/Smad3 Signaling. Cell Metabolism. 2011; 14:67-79.
Wu JJ, Quijano C, Wang J, Finkel T. Metabolism meets autophagy. Cell Cycle. 2010; 9:4780-4781.
Wu JJ, Quijano C, Chen E, Liu H, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M and Finkel T. Mitochondrial dysfunction and oxidative stress mediate physiological impairment induced by the disruption of autophagy. Aging. 2009; 1:425-437.
Hernandez-Saavedra D, Quijano C, Demicheli V, Souza JM, Radi R, McCord JM. Thiol-sensitive mutant forms of human SOD2, L60F, and I58T: The role of Cys 140. Free Radic. Biol. Med. 2010; 48:1202-1210.
Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas L. Cyclosporine A-Induced Nitration of Tyrosine 34 MnSOD in Endothelial Cells: Role of Mitochondrial Superoxide. Cardiovasc Res. 2010; 87:356-365.
Liu J, Cao L, Chen J, Song S, Lee I, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L, Ahn B, Kumar NJ, Rovira II, Daniels MP, Xu X, van Lohuizen M, Motoyama N, Deng C and Finkel T. Deletion of Bmi1 induces oxidative stress and activates the DNA damage response pathway. Nature. 2009; 459:388-393.
González-Pérez S, Quijano C, Romero N, Melø TB, Radi R, Arellano JB. Peroxynitrite inhibits electron transport on the acceptor side of higher plant photosystem II. Arch Biochem Biophys. 2008; 473:25-33.
Quijano C, Castro L, Peluffo G, Valez V and Radi R. Enhanced mitochondrial superoxide formation in hyperglycemic endothelial cells: Direct measurements and formation of hydrogen peroxide and peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 2007; 293: H340-14.
Demicheli V, Quijano C, Alvarez B, Radi R. Inactivation and nitration of human SODs by fluxes of nitric oxide and superoxide. Nitric oxide reaction with superoxide outcompetes SOD dismutation, generating peroxynitrite. Free Radic. Biol. Med. 2007; 42:1359-1368.
Tortora V, Quijano C, Freeman BA, Radi R, Castro L. Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione and peroxynitrite: Defining de mechanisms and relative contribution of these species to aconitase inactivation. Free Radic. Biol. Med. 2007; 42:1075-88.
Ye Y, Quijano C, Robinson KM, Ricart KC, Strayer AL, Shacka JJ, Kirk M, Barnes S, Radi R, Beckman BS, Estévez AG. Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine containing peptides. J. Biol. Chem. 2007; 282:6324-37.
Quijano C, Cassina A, Castro L, Rodríguez R and Radi R. Peroxynitrite: a mediator of nitric-oxide dependent mitochondrial dysfunction in pathology. Nitric Oxide, Cell Signaling, and Gene Expression. Santiago Lamas and Enrique Cadenas eds. Taylor & Francis Group, Florida. 2006; 99-143.
Quijano C, Romero N and Radi R. Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: Modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic. Biol. Med. 2005; 39, 728-41.
Radi R, Cassina A, Hodara R, Quijano C and Castro L. Peroxynitrite reactions and formation in mitochondria. Free Radic. Biol. Med. 2002; 33, 1451-64.
Ferrer-Sueta G, Quijano C, Alvarez B, Radi R. Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite. Methods Enzymol. 2002; 349:23-37.
Quijano C, Hernandez-Saavedra D, Castro L, McCord JM, Freeman BA and Radi R. Reaction of peroxynitrite with Mn-superoxide dismutase: Role of the metal center in decomposition kinetics and nitration. J. Biol. Chem. 2001; 276, 11631-8.
Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. J Biol Chem. 2001; 276:46017-23.
Cerecetto H, Di Maio R, Gonzalez M, Risso M, Sagrera G, Seoane G, Denicola A, Peluffo G, Quijano C, Stoppani AO, Paulino M, Olea-Azar C, Basombrio MA. Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. Structure-activity relationships. Eur. J. Med. Chem. 2000; 35:343-50.
Cerecetto H, Di Maio R, González M, Risso M, Saenz P, Seoane G, Denicola A, Peluffo G, Quijano C and Olea-Azar C. 1,2,5,-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships. J. Med. Chem. 1999; 42:1941-1950.
Quijano C, Alvarez B, Gatti RM, Augusto O and Radi R. Pathways of peroxinitrite oxidation of thiol groups. Biochem. J. 1997; 322, 167-73.
Current profession
Current professional activities type:ResearchTeachingAssociate Professor of Biochemistry at the School of Medicine in the Universidad de la República (UDELAR), Uruguay
Workshop and Conference Attended
2015 Uruguay Mini-Symposium ICGEB-CEINBIO: Frontiers in Biomedical Research2014 Uruguay 1st Conference of the South American Chapter of Cell Stress Society International2014 USA Cold Spring Harbor Laboratory Meeting Molecular Genetics of Aging2013 Cambridge, United Kingdom Cell Senescence in Cancer and Ageing2015 Brazil 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq)2014 Uruguay XV Jornadas de la Sociedad Uruguaya de Biociencias2013 Uruguay 8vas Jornadas de la Sociedad de Biooquímica y Biología Molecular2011 Uruguay 7as Jornadas de la Seccional Bioquímica y Biología Molecular de la Sociedad Uruguaya de Biociencias2008 USA Gordon Research Conference. Oxygen Radicals2007 Uruguay V Meeting of the Society for Free Radical Research – South American Group2006 Switzerland XIII Biennal Meeting of the Society for Free Radical Research International2005 Brazil IV Meeting of the South American Group of the Society for Free Radical Biology and Medicine2004 Argentina Society for Free Radical Research 12th Biennal Meeting2002 USA 9th Annual Meeting of the Oxygen SocietyAffiliations
Society for Free Radical Biology and Medicine (SFRBM)Presentation given
2015Metabolic reprogramming in cell senescence.Montevideo, UruguayEvent: Mini-Symposium ICGEB-CEINBIO: Frontiers in Biomedical Research2014Senescence: a cellular response to stressMontevideo, UruguayEvent: 1st Conference of the South American Chapter of Cell Stress Society International2014Inhibition of lipid synthesis activates the DNA damage response and triggers premature senescence in human fibroblastsCold Spring Harbor, NY, USAEvent: Cold Spring Harbor Laboratory Meeting Molecular Genetics of Aging2011El metabolismo de la célula senescente y su influencia sobre el fenotipo secretorMontevideo, UruguayEvent: 7as Jornadas de la Seccional Bioquímica y Biología Molecular de la Sociedad Uruguaya de Biociencias2006Enhanced mitochondrial superoxide formation during hyperglycemic challenge to endothelial cells: Impact on intracellular hydrogen peroxide levels and peroxynitrite formationDavos, SwitzerlandEvent: XIII Biennal Meeting of the Society for Free Radical Research International2002Superoxide and nitric oxide mitochondrial interactions in hyperglycemic vascular endothelial cellsSan Antonio, Texas, USAEvent: 9th Annual Meeting of the Oxygen Society -
Other Awards
May 2008National Institutes of Health (NIH) Intramural Research Training Award (IRTA) Fellowship.Postdoctoral fellowship at the National Institutes of Health (NIH) in Bethesda, Maryland, USA (2008-2011).Apr 2004Young Investigator Award from the “Society for Free Radical Biology and Medicine"Award to students attending the Society for Free Radical Biology and Medicine (SFRBM) 12th Biennial Meeting in Buenos Aires, ArgentinaApr 2006Young Investigator Award from the “Sociedad Uruguaya de Biociencias (SUB)”.Honorific Mention awarded by the Uruguayan Society of BioscienceNov 2011Sistema Nacional de Investigadores , Nivel INational System of Researchers, level I”. Award given by the “Agencia Nacional de Investigación e Innovación (ANII)" (National Agency for Investigation and Innovation (ANII). Uruguay.
