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Membership type: full

Sheila Villa

Country of origin: Mexico Currently in: Mexico, Monterrey General field of specialization: Medical and Health Sciences incl Neurosciences
Academic Background

Degrees

2018 Doctorate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

1. Cancer prevention and treatment 2. Neurodegeneration and diseases such as Parkinson's 3. Toxicology and natural products 4. Therapeutic vectors. Delivery systems for the nervous system


Publications resulting from Research: 


1. Villa-Cedillo SA, Acosta-Espinoza EJ, Soto-Domínguez A, Rodríguez-Rocha H, Montes-de-Oca-Saucedo CR, García-García A, Loera-Arias MJ, Ríos-Vazquez CS, Sánchez-Torres G, Valdés J, Saucedo-Cárdenas O. (2025) Antioxidant PRDX3 gene therapy protects brain cells and prevents neurodegeneration in an animal model of Parkinson's disease. Neuropeptides. 110:102494. doi: 10.1016/j.npep.2024.102494.
2. De-Leon-Covarrubias UE, Perez-Trujillo JJ, Villa-Cedillo SA, Martinez-Perez AG, Montes-de-Oca-Saucedo CR, Loera-Arias MJ, Garcia-Garcia A, Saucedo-Cardenas O, Montes-de-Oca-Luna R. Metabolites. (2024) Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment. 30;14(8):418. doi: 10.3390/metabo14080418.
3. Pioquinto-Avila E, González-Cruz AO, Solís-Estrada J, Hernández-Juarez J, Balderas-Rentería I, Villa-Cedillo SA, Pérez-Trujillo JJ, Arredondo-Espinoza E. Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins. Anticancer Res. 44(6):2567-2575. doi: 10.21873/anticanres.17062.
4. Martinez-Perez AG, Garza-Morales R, Loera-Arias MJ, Villa-Cedillo SA, Garcia-Garcia A, Rodriguez-Rocha H, Flores-Maldonado OE, Valdes J, Perez-Trujillo JJ, Saucedo-Cardenas O. (2024) Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model. Mol Biol Rep. 9;51(1):408. doi: 10.1007/s11033-024-09303-0.
5. Villa-Cedillo SA, Matta-Yee-Chig D, Soto-Domínguez A, Rodríguez-Rocha H, García-García A, Montes-de-Oca-Saucedo CR, Loera-Arias MJ, Valdés J, Saucedo-Cárdenas O. (2023) CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model. Neuropeptides. 102:102385. doi: 10.1016/j.npep.2023.102385.
6. Soto-Domínguez A, Salas-Treviño D, Guillén-Meléndez GA, Castillo-Velázquez U, Ballesteros-Elizondo RG, Montes-de-Oca-Saucedo CR, Villa-Cedillo SA, Morales-Ávalos R, Rodríguez-Tovar LE, Montes-de-Oca-Luna R, Saucedo-Cárdenas O. (2023) Histopathological, ultrastructural, and biochemical traits of apoptosis induced by peroxisomicine A1 (toxin T-514) from Karwinskia parvifolia in kidney and lung. Toxicon X. Dec 22;17:100148. doi: 10.1016/j.toxcx.2022.100148. eCollection 2023 Mar.
7. Soto-Domínguez A, Salas-Treviño D, Guillén-Meléndez GA, Castillo-Velázquez U, Ballesteros-Elizondo RG, Montes-de-Oca-Saucedo CR, Villa-Cedillo SA, Morales-Ávalos R, Rodríguez-Tovar LE, Montes-de-Oca-Luna R, Saucedo-Cárdenas O. (2022) Histopathological, ultrastructural, and biochemical traits of apoptosis induced by peroxisomicine A1 (toxin T-514) from Karwinskia parvifolia in kidney and lung. Toxicon X. doi: 10.1016/j.toxcx.2022.100148.
8. Guillén-Meléndez GA, Soto-Domínguez A, Loera-Arias MJ, Castillo-Velázquez U, Villa-Cedillo SA, Piña-Mendoza EI, Estrada-Castillón E, Chávez-Montes A, González-Alcocer A, Becerra-Verdín EM, Castañeda-Martínez A, Pérez-Hernández RA, Salas-Treviño D. (2022). Effect of methanolic extract of Mimosa malacophylla A.Gray in vero and HEK-293 cell lines, and in the morphology of kidney and bladder of rats with induced urolithiasis. J Ethnopharmacol. doi: 10.1016/j.jep.2022.115552.
9. Guillén-Meléndez GA, Villa-Cedillo SA, Pérez-Hernández RA, Castillo-Velázquez U, Salas-Treviño D, Saucedo-Cárdenas O, Montes-de-Oca-Luna R, Gómez-Tristán CA, Garza-Arredondo AJ, Zamora-Ávila DE, de Jesús Loera-Arias M, Soto-Domínguez A. (2021). Cytotoxic Effect In Vitro of Acalypha monostachya Extracts over Human Tumor Cell Lines. Plants (Basel). doi: 10.3390/plants10112326.
10. Villa-Cedillo SA, Soto-Domínguez A, Rodríguez-Rocha H, García-García A, de Jesús Loera-Arias M, Rivera-Chávez LF, Acosta-Espinoza EJ, Valdés J, Zavala-Flores LM, Montes-de-Oca-Luna R, Saucedo-Cárdenas O. (2019). The mRVG-9R peptide as a potential therapeutic vector to the central nervous system cells. Cell Biol Int. doi: 10.1002/cbin.11161.
11. Villa-Cedillo SA, Nava-Hernández MP, Soto-Domínguez A, Hernández-Ibarra JA, Perez-Trujillo JJ, Saucedo-Cárdenas O. (2019). Neurodegeneration, demyelination, and astrogliosis in rat spinal cord by chronic lead treatment. Cell Biol Int. doi: 10.1002/cbin.11147.
12. Soto-Domínguez A, Ballesteros-Elizondo RG, Santoyo-Pérez ME, Rodríguez-Rocha H, García-Garza R, Nava-Hernández MP, Villa-Cedillo SA, Montes-de-Oca-Luna R, Saucedo-Cárdenas O (2018). Peroxisomicine A1 (toxin T-514) induces cell death of hepatocytes in vivo by triggering the intrinsic apoptotic pathway. Toxicon. DOI: 10.1016/j.toxicon.2018.09.010
13. Villa-Cedillo SA, Rodríguez-Rocha H, Zavala-Flores LM, Montes-de-Oca-Luna R, García-García A, Loera-Arias MJ, Saucedo-Cárdenas O (2017). Asn194Lys mutation in RVG29 peptide increases GFP transgene delivery by endocytosis to neuroblastoma and astrocyte cells. Journal of Pharmacy and Pharmacology. DOI: 10.1111/jphp.12766.
14. Ramos-Treviño, J, Bassol-Mayagoitia, S, Ruiz-Flores, P, Espino-Silva, PK, Saucedo-Cárdenas, O, Villa-Cedillo, SA, Nava-Hernández, MP (2017). In vitro evaluation of damage by heavy metals in tight and gap junctions of sertoli cells. DNA and Cell Biology. doi: 10.1089/dna.2017.3839.
15. Villa-Cedillo SA, Saucedo-Cárdenas O (2017). Gene therapy with neurotrophic factors for neurodegenerative diseases. Revista Mexicana de Ciencias Farmacéuticas. https://www.redalyc.org/pdf/579/57956616002.pdf.
16. Martínez-Romero, A., Villa-Cedillo, SA., Bustamante-Gómez, JB., Ortega-Sánchez, JL., García-Luján, C., Alba-Romero, JJ. (2009). Specific detection of anti hiv-1 and anti hiv-2 antibodies by antigens with improved immunoreactivity. Revista Chapingo Serie Zonas Aridas. ISSN: 0186-3131 2009 8:223-227.



Current profession

Current professional activities type: 
Research
Teaching
Higher Education Study
Researcher and professor of Cellular and Tissue Biology at the Department of Histology. Faculty of Medicine, University Autonomous Community of Nuevo Leon in Monterrey, Mexico.

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