Member Profile
Membership type: affiliate
Brenda Wanjiru Muriithi
Country of origin: Kenya Currently in: Kenya, Nairobi General field of specialization: Structural, Cell and Molecular Biology-
Degrees
2018 Undergraduate Medical and Health Sciences incl Neurosciences -
Current Research Activities
Other
Using in silico bioinformatics, PCR, and sequencing approaches, I am currently interrogating the association of ABC Transporter G family member 2 (ABCG2) with amodiaquine, piperaquine, or lumefantrine resistance. Amodiaquine-resistant, piperaquine-resistant and lumefantrine-resistant Plasmodium berghei (P. berghei) ANKA parasites are being utilized as a surrogate for P. falciparum. Employing Clustal Omega, i am investigating the sequence conservation of the ABCG2 protein across different P. berghei orthologs, and ITASSER to determine ligand binding sites. I am currently mapping non-synonymous mutations by employing PCR and sequencing in the ligand binding regions.
Publications resulting from Research:
Beatrice Gachie, Jean Chepngetich, Brenda Muriithi, Kelvin Thiong’o, Jeremiah Gathirwa, Francis Kimani, Peter Mwitari, Gabriel Magoma, Daniel Kiboi (2023). Lumefantrine pressure selects nonsynonymous mutation in cysteine desulfurase IscS gene in the rodent malaria parasite Plasmodium berghei ANKA.
Beatrice Gachie, Kelvin Thiong’o, Brenda Muriithi, Jean Chepngetich, Noah Onchienku, Jeremiah Gathirwa, Peter Mwitari, Gabriel Magoma, Francis Kimani, Daniel Kiboi. Prevalence of mutations in the cysteine desulfurase IscS (Pfnfs1) gene in recurrent Plasmodium falciparum infections following artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) treatment in Matayos, Western Kenya.
Jean Chepngetich, Brenda Muriithi, Beatrice Gachie, Kevin Thiong'o, Mercy Jepkorir, Jeremiah Gathirwa, Francis Kimani, Peter Mwitari, Daniel Kiboi. Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA.
Current profession
Current professional activities type:Higher Education Study
Workshop and Conference Attended
2023 Nairobi, Kenya African BioGenome Project (AfricaBP) Open Institute East and Central Africa Regional Workshop 20232023 Nairobi, Kenya Exploring Innovations in Clinical Researches Conference
