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Membership type: full

Esther Maina

Country of origin: Kenya Currently in: Kenya, Nairobi General field of specialization: Medical and Health Sciences incl Neurosciences
Academic Background

Degrees

2000 Undergraduate Medical and Health Sciences incl Neurosciences
2005 Doctorate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

Actively involved in Cancer and anticancer medicinal plants' research in the Kenyan population. Specifically, involved in identifying and characterizing anticancer medicinal plants for Prostate and Breast Cancer. Also involved in the identification of biomarkers for PCa in the Kenyan (African) population with a view to clearly define the Phenotype/Genotype correlations compared to already published data, with a view to identify new molecular markers in our (Kenyan/African) population with a view to identify new drug targets and elucidate new signalling pathways for biomarkers identified.

Research Keywords: 
Anticancer agents
epigenetics
Human genetics
molecular biology

Publications resulting from Research: 


2018. Clove (Syzygium aromaticum) and honey extracts significantly reduce inflammatory cytokines and liver function enzymes in experimental rats fedon carbon tetrachloride (CCl4) accepted September 2018, published October 2018, Journal of Radiation Research and Applied Sciences, Mohamad T. Abdelrahman Esther N. Maina, Hany A. Elshemy

2018. Adsorptive Removal of Crystal Violet Dye from Aqueous Solution Using Water Hyacinth Roots.” Oral Paper presentation at THE INTERNATIONAL ESAECC-TCCA CONFERENCE, 3RD -7TH SEPTEMBER 2018, REEF HOTEL, MOMBASA, KENYA Wanyonyi, Maina et al

2018. α-Amylase Mediates Host Acceptance in the Braconid Parasitoid Cotesia flavipes, Gladys Bichang’a, Jean-Luc Da Lage, Claire Capdevielle-Dulac, Michel Zivy, Thierry Balliau, Kevin Samba, Bruno Le Ru, Laure Kaiser, Gerald Juma, Esther Njoki Mwangi Maina, Paul-André Calatayud August 2018 Journal of Chemical Ecology 44(1–2)
2017. Katabale MK, Esther NM and Kariuki D Phytochemical screening, Cytotoxic, genotoxic and mutagenic effects of the aqueous extract of Azadirachta indica leaves. International Journal of Herbal Medicine 2017; 5(3): 39-44

2016. Virginia N Njau, Esther NM Maina, Christopher O Anjili, Johnstone M Ingonga, Joan C Koech, Hellen W Kariuki, Peter K Ngure . In vitro antileishmanial activity and phytochemical analysis of Carissa edulis against Leishmania major African Journal of Pharmacology and Therapeutics. Vol 5, No 4 (2016)

2016. Efficacy of combination therapy using extracts of Aloe Secundiflora Eng l. And Callistemon citrinus William c. In Leishmania majorInfected balb/c mice. C. M. Ndeti, C. kituyi, M. Ndirangu, J. Ingonga, M. l. chimbevo, J. O. Ochieng, M. Barasa, G. Kinuthia, E. N. Maina, V. C. S. Nyambati , C. O. Anjili. East African Medical Journal Vol. 93 No. 2 February 2016

2014. Esther Njoki Maina a*, Helen Wambui Kinyi b, Dominic Omosa Ochwang’i c, Wycliffe Wanyonyi Chisutia d Liver toxicity of crude ethanolic extract of Ficus natalensis traditionally used in South Western Uganda, African Journal of Pharmacology and Therapeutics. 3(4):116-121

2014. Maina E.N, Skowronska A., Chaganti S. , Taylor M.A, Murray P.G., Stankovic T., 2014. EBV infection and the DNA damage response in lymphomas if B-cell origin. 16-17 October. 3rd Medical and Veterinary Virus Research in Kenya (MVVRK-3) symposium. , Hilton Hotel; Nairobi

2014. Esther Njoki Maina a*, Helen Wambui Kinyi b, Dominic Omosa Ochwang’i c, Wycliffe Wanyonyi Chisutia d Liver toxicity of crude ethanolic extract of Ficus natalensis traditionally used in South Western Uganda, 3rd-5th September, 2014. 9th Biennial Scientific conference, College of Agriculture and Veterinary Science, University of Nairobi

2013. Maina E.N.M. Lifestyle diseases pose a definite threat to the developing world. (Invited mini-review by Editor ) -Your Doctor Magazine- online publication url: www.yourdoctormagazine.co.ke

2012. Esther N. Maina , Tessa Webb , John R Arrand , Joyce Whittington , Sarita Soni, Harm Boer , David Clarke , Anthony J. Holland. Investigation of Prader-Willi-like Phenotype using a Whole Genome Array. African Journal of Pharmacology and Therapeutics. 1(3):84-91
2012. Maina E.N.M. Looking to the study of genes for cancer diagnoses and Treatment. (Invited mini-review by Editor) -Your Doctor Magazine 2012 Jul; 4 (5-6)

2009. Bose S, Yap LF, Fung M, Starzcynski J, Saleh A, Morgan S, Dawson C, Chukwuma MB, Maina E, Buettner M, Wei W, Arrand J, Lim PV, Young LS, Teo SH, Stankovic T, Woodman CB, Murray PG. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. J Pathol. 2009; 217(3):345-52.

2009. Marston E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A, Skowronska A, Mapp K, Sameith K, Powell JE, Lawson S, Kearns P, Falciani F, Taylor M, Stankovic T. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Blood. 2009 1;113 (1):117-26.

2008. Tessa Webb, Esther N. Maina, Sarita Soni, Joyce Whittington, Harm Boer, David Clarke, Anthony Holland. In search of the psychosis gene in people with Prader-Willi syndrome. Am J Med Genet A. 2008 Apr 1; 146 (7):843-53.

2008. S. Soni, J. Whittington, A. J. Holland, T. Webb, E. N. Maina, H. Boer and D. Clarke. The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome. Psychol. Med. 2008 Jan 4:1-10.

2007. Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D. The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment. J Intellect Disabil Res. 2007 Jan; 51(Pt 1):32-42.

2006. Maina EN, Webb T, Soni S, Whittington J, Boer H, Clarke D, Holland A. Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter. J. Hum. Genet. 2007; 52(4):297-307.

2006. Maina EN, Abdulrahman M, Morris MR, Zatyka M, Raval RR, Banks RE, Wiesener MS, Richards FM, Johnson CM, Latif F, Maher ER. Identification of novel VHL targets that are associated with the development of renal cell carcinoma. Oncogene. 2007 Mar 8; 26(11):1661-72. Epub 2006 Sep 25.

2006. Smith UM, Consugar M, Tee LJ, McKee BM, Maina EN, Whelan S, Morgan NV, Goranson E, Gissen P, Lilliquist S, Aligianis IA, Ward CJ, Pasha S, Punyashthiti R, Malik Sharif S, Batman PA, Bennett CP, Woods CG, McKeown C, Bucourt M, Miller CA, Cox P, Algazali L, Trembath RC, Torres VE, Attie-Bitach T, Kelly DA, Maher ER, Gattone VH 2nd, Harris PC, Johnson CA. The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Nat Genet. 2006 Feb; 38(2):191-6. Epub 2006 Jan 15.

2005. Morris MR, Gentle D, Abdulrahman M, Maina EN, Gupta K, Banks RE, Wiesener MS, Kishida T, Yao M, Teh B, Latif F, Maher ER Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. Cancer Res. 2005 Jun 1; 65(11):4598-606.
2005. Maina EN, Morris MR, Zatyka M, Raval RR, Banks RE, Richards FM, Johnson CM, Maher ER. Identifi-cation of novel VHL target genes and relationship to hypoxic response pathways. Oncogene. 2005 Jun 30; 24(28):4549-58.

2005. Aligianis IA, Johnson CA, Gissen P, Chen D, Hampshire D, Hoffmann K, Maina EN, Morgan NV, Tee L, Morton J, Ainsworth JR, Horn D, Rosser E, Cole TR, Stolte-Dijkstra I, Fieggen K, Clayton-Smith J, Megarbane A, Shield JP, Newbury-Ecob R, Dobyns WB, Graham JM Jr, Kjaer KW, Warburg M, Bond J, Trembath RC, Harris LW, Takai Y, Mundlos S, Tannahill D, Woods CG, Maher ER. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet. 2005 Mar; 37(3):221-3.

2004. Maina E, Morris MR, Morgan NV, Gentle D, Astuti D, Moch H, Kishida T, Yao M, Schraml P, Richards FM, Latif F, Maher ER. Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. J Clin Pathol. 2004 Jul; 57(7):706-11.



Current profession

Current professional activities type: 
Teaching
Other
Currently I am a Senior Lecturer, Department of Biochemistry, Chiromo Campus, University of Nairobi (Kenya). My main duties at the department of Biochemistry include teaching biochemistry, genetics and molecular biology to both undergraduate and postgraduate students; actively involved in proposal writing for research grants; departmental representative on university Committees on Curriculum Development, Postgraduate Studies, and Timetabling; member of departmental committees on Strategic Planning and Higher Degrees.

Affiliations

Biochemical Society of Kenya
International Federation of University Women (IFUW)
Third World Organization for Women in Science (TWOWS)
African Women’s Forum on Science and Technology (AWFST)
• African Technology Policy Studies Network (ATPS)