DR VRUSHALI PATIL
About me
Dr. Vrushali N. Patil is a researcher in Chemical Sciences and currently serves as Head of the Training Department at Haffkine Institute for Training, Research and Testing, Mumbai. Her research focuses on medicinal chemistry, including the design and development of anti-filarial agents and rabies-related therapeutic research. She integrates synthetic chemistry with computational approaches such as molecular docking and DFT to advance drug discovery. In addition to her research activities, she actively contributes to scientific training, research mentoring, and translational initiatives in biomedical sciences.
I am a medicinal chemist and Senior Scientific Officer at the Haffkine Institute for Training, Research & Testing, Mumbai, India, where I also serve as Head of the Training Department. My research focuses on translational drug discovery for neglected tropical and infectious diseases, particularly the development of anti-filarial agents and rabies-related therapeutics—conditions that continue to impose a significant public health burden in low- and middle-income countries.
My work integrates synthetic organic chemistry with computational approaches such as molecular docking and density functional theory (DFT) to support rational drug design and the identification of novel bioactive molecules. I am particularly interested in developing affordable and locally relevant therapeutic strategies aligned with global health priorities.
Beyond my research, I actively contribute to institutional capacity building, research strategy development, and scientific training within a public-sector research institute of national importance. I support grant development, interdisciplinary collaborations, and alignment with national and international funding missions addressing infectious diseases. As a recognized Ph.D. and M.Sc. research guide, I am committed to mentoring early-career researchers and advancing women’s leadership and representation in science, particularly across the Global South.
Degrees:
screening of β-tubulin and thioredoxin reductase in Brugia malayi: a step toward novel
anti-filarial agents. In Silico Pharmacology. 2025;13(3):178.
2. Patil SR, Asrondkar A, Patil V, Sangshetti JN, Khan FAK, Damale MG, Shinde DB.
Antileishmanial potential of fused 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiols: synthesis,
biological evaluations and computational studies. Bioorg Med Chem Lett.
2017;27(16):3845–50.
3. Patil V, Asrondkar A, Bhadane V, Bobade AS, Chowdhary A. Synthesis and anti
inflammatory activity of 2-amino-6-methoxy benzothiazole derivative. IOSR J Appl
Chem. 2015;8(8):1–2.
4. Patil V, Asrondkar A, Mishra N, Bobade AS, Chowdhary A. Biological evaluation of
some synthesized benzothiazole derivatives and their characterization. World J Pharm
Res. 2015;4(2):842–50.
5. Mahajan P, Nikam M, Chate A, Nimbalkar U, Patil V, Bobade A, Chowdhary A,
Deolankar D, Javale B, Gill C. Synthesis, antioxidant, anti-inflammatory and
antimicrobial screening of new thiophene fused aryl pyrazolyl 1,3,4-oxadiazoles.
Phosphorus Sulfur Silicon Relat Elem. 2015;190(11):1803–13.
6. Patil V, Shinde O, Asrondkar A, Bobade AS, Chowdhary AS. Comparative studies on
synthesis of 2-chloro-N-(2,5-dihydro-1,3,4-thiadiazol-2-yl) acetamide using microwave
irradiation and conventional techniques and their antioxidant activity. IOSR J Appl Chem.
2014;7(4):10–5.
7. Patil VN, Asrondkar AL, Pande S, Bobade AS, Chowdhary AS. Synthesis of 5-aryl-3-(5
bromo-3-benzofuran-2-yl)-1-pyrazole as antimicrobial agent. IOSR J Pharm Biol Sci.
2013;8(4):4–8.
8. Asrondkar AL, Patil VN, Mishra NU, Bobade AS, Chowdhary AS. Synthesis and study
of (5Z)-5-[(4-oxo-4H-chromen-3-yl)methylidene]-1,3-thiazolidine-2,4-dione derivative.
Der Pharm Chemica. 2013;5(4):288–92.
9. Patil VN, Yadav AG, Asrondkar AL, Naik AA, Ansulkar PV, Bobade AS, Chowdhary
AS. Anti-oxidant and anti-microbial activities of pyrazolyl-benzothiazole derivatives
using Vilsmeier–Haack reaction. Rasayan J Chem. 2012;1:117–20.
10. Patil V, Yadav A, Bobade AS, Patil LS, Athlekar SV, Chowdhary AS. Synthesis and
evaluation of new benzothiazole derivatives as potential anti-microbial agents. Res J
Pharm Chem Technol. 2010;3(4):1044–6.
11. Patil V, Yadav A, Bobade AS, Patil LS, Athlekar SV, Chowdhary AS. Synthesis and
biological evaluation of new benzothiazole derivatives. Asian J Res Chem. 2009;2(4):1
3.
12. Patil VN, Yadav AG, Asrondkar AL, Gajbhiye SP, Bobade AS, Chowdhary AS.
Synthesis of substituted-benzoic acid (1-(1-benzothiazol-2-yl-3-(substituted phenyl)-1H
pyrazol-4-yl)-meth-(E)-hydrazide) as possible anti-microbial agents. Bull Haffkine Inst.
2009;13(1):26–9.
13. Yadav A, Patil V, Bobade AS, Athlekar SV, Chowdhary AS. Synthesis of 2,4
disubstituted thiazole derivatives containing 1,2,4-triazole ring system as antimicrobial
agents. Indian J Heterocycl Chem. 2009;19:21–4.