Doctor Eugenia Flores-Giubi
About me
I am a Principal Investigator in the Department of Chemical Biology at the Facultad de Ciencias Químicas, National University of Asunción (Paraguay), and a Researcher Level II (CONACYT). I hold a Ph.D. in Sciences from the University of Cádiz (Spain). My research focuses on natural products from plants and fungi, particularly their structural elucidation and biological activity. I have extensive experience in research, teaching, and academic leadership.
I am a researcher at the National University of Asunción (Paraguay) and a Researcher Level II recognized by CONACYT. I hold a Ph.D. in Sciences from the University of Cádiz (Spain), where I also earned an M.Sc. in Chemical Sciences and Technologies. In addition, I obtained an M.Sc. in Plant Sciences and Biotechnology from the Scientific Research Center of Yucatán (Mexico), and a B.Sc. in Biochemistry and Clinical Biochemistry from the National University of Asunción.
My research focuses on natural products from plants and fungi, including their isolation, structural elucidation, synthesis, and evaluation of biological activity, particularly in health and agricultural applications. I am especially interested in developing analytical and biotechnological approaches to characterize bioactive compounds and support their practical applications.
In addition to my research, I serve as a faculty representative on the Governing Council of the Faculty of Chemical Sciences, contributing to institutional decision-making and academic governance. I previously served as Academic Director (2021–2025) and Director of Postgraduate Studies (2016–2017). I have extensive teaching experience at both undergraduate and graduate levels in Biochemistry, Analytical Chemistry, and General Chemistry, and I actively supervise undergraduate, Master’s, and Ph.D. theses.
Throughout my career, I have integrated research, teaching, and academic leadership, contributing to the training of human resources and the advancement of scientific research in Paraguay.
Degrees:
Rodríguez, M. C., Macías-Sánchez, A., & Flores-Giubi, M. E. (2025). Soybean
leaf infusion culture media and phytotoxic metabolite production in
Macrophomina phaseolina. Agronomía Mesoamericana, 36,
x1y07135. https://doi.org/10.15517/x1y07135
Pineda Amiliana; Orrego A; Iehisa JC Masaru; Flores-Giubi M.E.; Barua J.E.;
Sánches-Lucas, R; Jorrín-Novo J; Romero-Rodríguez C.;
Secretome analysis of the phytopathogen Macrophomina phaseolina cultivated
in liquid medium supplemented with and without soybean leaf infusion, Fungal
Biology, v. 127 f: 5, p. 1042-1043, 2023.
Benegas Andrea; Cubilla Rios A.A.; Flores-Giubi M.E.; Barua-Chamorro J. E.;
Romero-RodríguezC. Extracción de proteínas secretadas por el fitopatógeno
Macrophomina phaseolina: Selección de un método eficiente que incluye
estímulo con tejido de su hospedero, Scientia Agropecuaria, v. 13 f: 2, 2022.
Orrego A; Gavilán, MC; Arévalos, A; Ortiz, B; Gaete Humada, B; Pineda
Amiliana; Romero-Rodríguez C.; Flores-Giubi M.E.; Kohli, MM; Iehisa JC
Masaru. Identification of reference genes and their validation for gene
expression analysis in phytopathogenic fungus Macrophomina phaseolina,
PLOS ONE, 2022.
González-Maldonado P; Alvarenga N.; Burgos Alberto; Flores-Giubi M.E.;
Barua-Chamorro J. E.; Romero-Rodríguez C.; Soto-Rifo, R; Valiente-Echeverría
F; Langjahr P; Cantero-González G; Sotelo P.; Screening of Natural Products
Inhibitors of SARS-CoV-2 Entry, Molecules, v. 27, p. 1743, 2022.
Andrés Sanabria; Cubilla Rios A.A.; Flores-Giubi M.E.; Barua-Chamorro J. E.;
Romero-Rodríguez C.; Enciso-Maldonado G.A.; Thiessen L.D.; Shew D. First
Report of Macrophomina euphorbiicola Causing Charcoal Rot of Stevia in
Paraguay, Plant Disease, v. 107, p. 229, 2022.
Bogado-Villalba, L., Nakayama Nakashima, H., Britos, R., Iehisa J.C.M., Flores-
Giubi M.E. Genotypic characterization and steviol glycoside quantification in a
population of Stevia rebaudiana Bertoni from Paraguay. J. Crop Sci.
Biotechnol. 24, 145–152 (2021).
M. Eugenia Flores-Giubi, Jose Manuel Botubol-Ares, María J. Durán-Peña,
Felipe Escobar-Montaño, David Zorrilla, Jesús Sánchez-Márquez, Eduardo
Muñoz, Antonio J. Macías-Sánchez, Rosario Hernández-Galán. Bond reactivity
indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton
diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone.
Phytochemistry, Volume 180, 2020,112519.
Flores-Giubi M.E.; Geribaldi Noelia; Murillo-Carretero M.; Castro C. ; Duran
Patron, Rosa; Macías-Sánchez A.; Hernández-Galán R.; Lathyrane,
Premyrsinane, and Related Diterpenes from Euphorbia boetica: Effect on in
Vitro Neural Progenitor Cell Proliferation, Journal of Natural Products, v. 82 f: 9,
p. 2517-2528, 2019.
Bobadilla Dario; Flores-Giubi M.E.; Nelson Alvarenga; Synergistic effect of (s)-
cis-verbenol with the antibiotics amoxicillin and gentamicin against sensitive and
resistant Staphylococcus aureus strains, International Journal of
Pharmaceutical Sciences and Research, v. 10 f: 5, p. 2188, 2019.
Cubilla-Ríos, A., Ruíz-Díaz-Mendoza, D., Romero-Rodríguez, M., Flores-Giubi,
M., & Barúa-Chamorro, J. Antibiosis of proteins and metabolites of three
species of Trichoderma against paraguayan isolates of Macrophomina
phaseolina. Agronomía Mesoamericana, 30(1), 63-77, 2019.
Cáceres, A.; Flores-Giubi, M.E.; Romero Rodríguez, C.; Alvarenga, N. In vitro
anthelmintic activity and chemical composition of methanol extracts and
fractions of Croton paraguayensis and Vernonia brasiliana against Eisenia
foetida, Asian Pacific Journal Of Tropical Disease, v. 7 f: 2, p. 71-74, 2017.
ISSN/ISBN: 2222-1808.
Durán-Peña M.J.; Flores-Giubi M.E.; Botubol-Ares, J.M.; Escobar-Montaño
Felipe; Macías-Sánchez A.; Echeverri F.; Gonzalez Collado I.; Hernández
Galán R. Lathyrane Diterpenes from the Latex of Euphorbia laurifolia, Natural
Product Communications, v. 12 f: 5, p. 671-673, 2017. ISSN/ISBN: 1555-9475.
Flores-Giubi M.E.; Durán-Peña M.J.; Botubol-Ares, J.M.; Escobar-Montaño
Felipe; Zorrilla David; Macías-Sánchez A.; Hernández Galán R. Gaditanone, a
Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from
Euphorbia gaditana, Journal of Natural Products, v. 80, p. 2161-2165, 2017.
ISSN/ISBN: 0163-3864.
Murillo-Carretero M.; Geribaldi N.; Flores-Giubi M.E.; García-Bernal, F.;
Navarro-Quiroz Elkin A; Carrasco M.; Macías-Sánchez A.; Herrero-Foncubierta
Pilar; Delgado-Ariza Antonio; Verastegui-Escolano C.; Domínguez-Riscart, J.;
Daoubi M.; Hernández Galán R.; Castro, C. ELAC (3,12-di-O-acetyl-8-Otigloilingol),
a plant-derived lathyrane diterpene, induces subventricular zone
neural progenitor cell proliferation through PKC beta activation, British Journal
of Pharmacology, v. 174, p. 2373-2392, 2017. ISSN/ISBN: 0007-1188.
Flores-Giubi M.E.; Durán-Peña M.J.; Botubol-Ares, J.M.; Harwood, L.M.;
González-Collado I.; Macías-Sánchez A.; Hernández Galán R. Chemoselective
and stereoselective lithium carbenoid mediated cyclopropanation of acyclic
allylic alcohols, Organic & Biomolecular Chemistry, v. 14, p. 2731-2741,
2016.ISSN/ISBN: 1477-0539.
Flores-Giubi M.E.; Geribaldi N.; Murillo-Carretero M.; García-Bernal, F.;
Carrasco M.; Macías-Sánchez A.; Domínguez-Riscart, J.; Verastegui-Escolano
C.; Hernández Galán R.; Castro, C. 12-Deoxyphorbols promote adult
neurogenesis by inducing neural progenitor cell proliferation via PKC activation ,
International Journal of Neuropsychopharmacology, v. 19 f: 1, p. 1-14, 2015.
ISSN/ISBN: 1461-1457.
Flores-Giubi M.E.; Diaz-Brito, M.A.; Brito-Argáez, L.; García-Sosa, K.;
Escalante-Erosa F.; Pena-Rodriguez; L.M.; Islas-Flores I. Purification of p47f, a
Necrosis-Inducing Protein Fraction from the Secretome of Phytophthora capsici,
Journal of Phytopathology-Phytopathologische Zeitschrift, 2014.ISSN/ISBN:
0931-1785.
Flores-Giubi M.E.; Brito-Argáez, L.; García-Sosa, K.; Escalante-Erosa F.; Islas-
Flores I.; Pena-Rodriguez; L.M. Optimization of Culturing Conditions of a Strain
of Phytophthora capsici Pathogenic to Habanero Pepper (Capsicum chinense),
Journal of Phytopathology-Phytopathologische Zeitschrift, Journal of
Phytopathology-Phytopathologische Zeitschrift, v. 161 f: 11-12, p. 807-813,
2013. ISSN/ISBN: 0931-1785.