About me

Lakshika Dissanayake is a Ph.D. candidate in Molecular Biology, Microbiology, and Biochemistry at Southern Illinois University Carbondale, specializing in synthetic microbiology and sustainable biotechnologies. Her research focuses on engineering microbial systems for the upcycling of plastic and textile waste into high-value bioproducts, including bio-nylon precursors and platform chemicals. She holds an M.S. (GPA 4.00) from SIU and an M.Sc. in Biotechnology from the University of Peradeniya, Sri Lanka.

Lakshika has authored multiple peer-reviewed publications and numerous conference presentations centered on microbial engineering, PET biodegradation, and circular bioeconomy solutions. She has received several prestigious awards and fellowships, including the EREF Ph.D. Scholarship, Sigma Xi research awards, the SIUC 3MT Competition Winner, and national recognition in agricultural research in Sri Lanka. In addition to her research, she has served as a Graduate Research and Teaching Assistant and is an active member of several professional scientific societies.

Lakshika Dissanayake is a molecular microbiologist and biotechnology researcher specializing in synthetic microbiology, metabolic engineering, and sustainable bioprocess development. She is currently a Ph.D. candidate in Molecular Biology, Microbiology, and Biochemistry at Southern Illinois University Carbondale (SIUC), where her research centers on developing innovative chemo-biological hybrid systems to upcycle plastic and textile waste into high-value bioproducts. Her doctoral work focuses on engineering novel microbial chassis, particularly Erwinia species, to enable circular bioeconomy solutions, including the production of bio-nylon precursors, jet fuel intermediates, and platform chemicals from waste materials.

Lakshika earned her M.S. in Molecular Biology, Microbiology, and Biochemistry from SIUC with a perfect 4.00 GPA. During her master’s research, she engineered Erwinia aphidicola as a “catabolic powerhouse” capable of deconstructing and upcycling synthetic polymers such as polyethylene terephthalate (PET). Prior to this, she completed an M.Sc. in Biotechnology at the University of Peradeniya, Sri Lanka, where her research focused on molecular characterization of rice germplasm for bacterial leaf blight resistance genes. She received her B.Sc. (Hons) in Applied Biology with a specialization in Microbiology from Rajarata University of Sri Lanka.

Her scholarly contributions include multiple peer-reviewed journal publications in leading international journals spanning microbial engineering, enzyme optimization, PET biodegradation, and sustainable biomanufacturing. She has also authored and co-authored numerous conference proceedings and presentations at national and international forums, including ACS regional and national meetings, ASM conferences, SIMB annual meetings, and interdisciplinary research symposia. Several additional manuscripts are currently under review or in preparation, reflecting her continued productivity and leadership in the field of plastic and biomass valorization.

Throughout her academic career, Lakshika has held positions as a Graduate Research Assistant and Graduate Teaching Assistant at SIUC, where she conducted advanced research in synthetic microbiology and taught undergraduate microbiology laboratory courses. She previously worked as a Research Scientist at John Keells Research in Sri Lanka, gaining experience in molecular biology techniques, microbiology, tissue culture, and greenhouse trials. She also served as a Demonstrator in Botany at Rajarata University, supporting undergraduate instruction.

Her work has been recognized with numerous competitive awards and honors. She is a recipient of the Environmental Research & Education Foundation (EREF) Ph.D. Scholarship and multiple doctoral fellowships from SIUC. Her awards include the Sigma Xi Rose and Essie Padgett Scholarship Award, Outstanding Graduate Presentation honors, Top Poster Awards, the Love of Learning Award from Phi Kappa Phi, and victory in the 2023 SIUC Three Minute Thesis (3MT) competition. Internationally, she was part of a team receiving the SLCARP National Award for Excellence in Agricultural Research in Sri Lanka. She has also secured multiple professional development and travel grants to present her research nationally and internationally.

Lakshika maintains active membership in several professional organizations, including the American Society for Microbiology (ASM), the American Chemical Society (ACS), the Society for Industrial Microbiology and Biotechnology (SIMB), Sigma Xi, Phi Kappa Phi Honor Society, the Organization for Women in Science for the Developing World (OWSD), and the Institute of Biology Sri Lanka. Beyond research, she contributes to academic service activities such as judging science fairs and research forums and mentoring students.

Through her interdisciplinary expertise in molecular biology, enzyme engineering, and microbial biotechnology, Lakshika Dissanayake continues to advance sustainable solutions for global waste challenges, bridging fundamental microbiology with applied industrial biotechnology to support the transition toward a circular and environmentally responsible bioeconomy.

icon-membership
Other Memberships/Affiliations
Institute of Biology, Sri Lanka
The Honor Society of Phi Kappa Phi
American Society for Microbiology (ASM)
American Chemical Society (ACS)
Solid Waste Association of North America (SWANA)
Sigma Xi
Society for Industrial Microbiology and Biotechnology (SIMB)

Degrees:

2019
Master
Agricultural Sciences
2016
Undergraduate
Biological Systems and Organisms

Publications resulting from Research
Lakshika Dissanayake, Jeffry G. Linger, Lahiru N. Jayakody; Complete genome of Erwinia spp. str. LJJL01 isolated from waste charcoal; Microbiol. Resour. Announc. 2025, doi.org/10.1128/mra.00347-25
Lakshika Dissanayake and Lahiru Jayakody; Engineering Microbes to Bio- Upcycle Polyethylene Terephthalate. Front. Bioeng. Biotechnol. 2021, doi:10.3389/fbioe.2021.656465.
Sandhya K. Jayasekara, Hriday Dhar Joni, Bhagya Jayantha, Lakshika Dissanayake, Christopher Mandrell, Manuka M. S. Sinharage, Ryan Molitor, Thushari Jayasekara, Poopalasingam Sivakumar, Lahiru N. Jayakody; Trends in in-silico guided engineering of efficient polyethylene terephthalate (PET) hydrolyzing enzymes to enable bio-recycling and upcycling of PET; Computational and Structural Biotechnology Journal., 2023, doi.org/10.1016/j.csbj.2023.06.004
Dissanayake, D.M.L.N.K, Hettiarachchi S. and Sarananda K.H (2017) Shelf-life extension of mixed fruit nectar packaged in PET bottles by increasing acidity; Peradeniya University International Research Sessions(IPURSE 2017) - conference proceedings
D.M.L.N.K. Dissanayake, S. Udage, N.H.L.D.L.D. Nanayakkara, H.M.V.G. Herath and D.V.Jayatilake (2018) Haplotype analysis and molecular marker development for bacterial leaf blight resistance gene xa13 ; International Conference on Bioscience and Biotechnology 2019(Malaysia) - Abstract
Sandhya Jayasekara, Lakshika Dissanayake, Lahiru Jayakody; Opportunities in the microbial valorization of sugar industrial organic waste to biodegradable smart food packaging materials. Int J Food Microbiol., 2022, doi: 10.1016/j.ijfoodmicro.2022.109785.
Dhanesha Nanayakkara, Iresha Edirisingha, Lakshika Dissanayake, Deepika Weerasinghe, Lalith Suriyagoda, Venura Herath, Chandrika Perera, Dimanthi Jayatilake; A novel intragenic marker targeting the ectodomain of bacterial blight- resistance gene Xa21 for marker-assisted selection in rice, J. Crop Improv., 2021, doi:10.1080/15427528.2020.1771643.
Iresha Edirisinghe, Thamali Kariyawasam, Dhanesha Nanayakkara, Lakshika Dissanayake, Akila Amarathunge, Deepika Weerasinghe, Lalith Suriyagoda, Chandrika Perera and Dimanthi Jayatilake; Allele profiling of bacterial blight resistance genes Xa4, Xa38, and Xa21 in selected Sri Lankan rice germplasm; 35th Annual PGIA congress 2023- University of Peradeniya, Sri Lanka
Lakshika Dissanayake, Saptarshi Ghosh, Dushmantha Madushanka, Bhagya Sri Kolitha, Sandhya Jayasekara, Isabelle Hou, Lahiru N. Jayakody; Designing an efficient biocatalyst for a chemobio hybrid upcycling of waste textile; ACS Midwest Regional Meeting 2025
Lakshika Dissanayake, Elwood Sheflin, Bhagya Sri Kolitha, Sandhya Jayasekara, Dushmantha Madushanka, Isabelle Hou, Lahiru N. Jayakody; Engineered Erwinia renovo LJJL01 as a novel biocatalyst for producing cis,cis-Muconate from textile waste; 47th Symposium on Biomaterials, Fuels and Chemicals 2025
Lakshika Dissanayake, Saptarshi Ghosh, Dushmantha Madushanka, Bhagya Sri Kolitha, Elwood Sheflin, Sandhya Jayasekara, Isabelle Hou, Lahiru N. Jayakody; Engineering novel bacterium Erwinia renovo LJJL01 for bio-nylon production from textile waste; 2025 Creative Activities and Research Presentation- Southern Illinois University, Carbondale
Isabelle Hou, Lakshika Dissanayake, Lahiru Jayakody; Feedback inhibition on PET degradation enzymes, a potent challenge for biological recycling; ACS Midwest Regional Meeting 2025
Lahiru Jayakody, Lakshika Dissanayake, Bhagya Jayantha, Cole Beard; Conversion of waste biomass and plastic into platform chemicals via microbial biocatalysts for the synthesis of advanced nylon analogs; ACS Midwest Regional Meeting 2025
Dushmantha Madushanka, Lakshika Dissanayake, Saptarshi Ghosh, Lahiru N. Jayakody; From Plastic Waste to Platform Chemicals: Engineering Erwinia renovo LJJL01 as a Next-Generation Microbial Chassis for PET Upcycling and Aromatic Bioconversion; ASME 2025 International Mechanical Engineering Congress and Exposition (IMECE2025)
Dushmantha Madushanka, Lakshika Dissanayake, Saptarshi Ghosh, Sandhya Jayasekara, Bhagya Sri Kolitha, Lahiru N. Jayakody; Evaluating the chemical tolerance of Erwinia renovo LJJL01 for its advancement as a revolutionary microbial cell factory for plastic upcycling; 2025 Creative Activities and Research Presentation- Southern Illinois University, Carbondale
Lakshika Dissanayake, Bhagya Sri Kolitha, Sandhya Jayasekara, Isabelle Hou, Abigail Sparks, Lahiru Jayakody; Valorizing cotton-PET textile waste into jet fuel precursor; SIMB 2024 Annual Meeting
Lakshika Dissanayake, Bhagya Sri Kolitha, Sandhya Jayasekara, Isabelle Hou, Abigail Sparks, Lahiru Jayakody; A novel chemo-biological hybrid system to upcycle textile waste to jet fuel precursor; 2024 Creative Activities and Research Presentation- Southern Illinois University, Carbondale
Manuka M. S. Sinharage, Ryan Molitor, Hriday Dhar Joni, Christopher Mandrell, Lakshika Dissanayake, Sandipty Kayastha, Thushari Jayasekera, P Sivakumar, Lahiru Jayakody; In-silico engineering of MHETase-like enzyme, Mle046; International Symposium on Molecular Spectroscopy 2024
Ryan Molitor, Manuka M. S. Sinharage, Hriday Dhar Joni, Christopher Mandrell, Lakshika Dissanayake, Sandipty Kayastha, Thushari Jayasekera, P Sivakumar, Lahiru Jayakody; Investigating the Effect of Metal-Site Substitutions on Thermal Stability and PET Depolymerization Activity on Leaf-Branch Compost Cultinase (LCC); International Symposium on Molecular Spectroscopy 2024
Lakshika Dissanayake, Sandhya Jayasekara, Abigail Sparks, Bhagya Sri Kolitha, Lahiru Jayakody; Development of Erwinia renovo LJJL01, an industrially relevant novel catabolic powerhouse; 2023 Graduate Research Forum- Southern Illinois University, Carbondale
Bhagya Jayantha, Kara Rollins, Lakshika Dissanayake, Sandhya Jayasekara, Sandipty Kayastha, Abigail Sparks, Lahiru N. Jayakody; Bio-functionalizing waste caffeine into high value biochemicals; 2023 Graduate Research Forum- Southern Illinois University, Carbondale
Lakshika Dissanayake, Sandipty Kayastha, Sandhya Jayasekara, Bhagya Sri Kolitha, Ryaan Ligon, Abigail Sparks, Lahiru N. Jayakody; Engineering Erwinia aphidicola LJJL01 to upcycle cotton-PET textile waste; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Sandhya Jayasekara, Sandipty Kayastha, Lakshika Dissanayake, Bhagya Jayantha, Abigail Sparks, Scott Hamilton-Brehm, Thushari Jayasekera, Sivakumar Poopalasingam, Christopher Mandrell, Lahiru Jayakody; Characterization of a potent sorbitol dehydrogenase from a novel thermophilic subsurface bacterium Caldiatribacterium inferamans SIUC1; SIMB 2023 Annual Meeting
Bhagya Jayantha, Lakshika Dissanayake, Sandhya Jayasekara, Sandipty Kayastha, Abigail Sparks, Lahiru Jayakody; Trash to cash: microbial production of high-value 7-methylxanthine; SIMB 2023 Annual Meeting
Ryaan Ligon, Lakshika Dissanayake, Bhagya Sri Kolitha, Sandhya Jayasekara, Abigail Sparks, Sandipty Kayastha, Ken Anderson, Lahiru Jayakody; Metabolic engineering of novel catabolic powerhouse Erwinia aphidicola LJJL01 to produce bioplastic precursors; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Bhagya Jayantha, Lakshika Dissanayake, Sandhya Jayasekera, Sandipty Kayastha, Abigail Sparks, Lahiru N Jayakody; Trash to cash: Microbial production of high-value 7-methylxanthine; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Sandhya Jayasekara, Sandipty Kayastha, Lakshika Dissanayake, Bhagya Sri Kolitha, Abigail Sparks, Scott D Hamilton-Brehm, Thushari Jayasekara, and Lahiru N. Jayakody; Mining microbes for hidden treasures: Molecular cloning and characterization of an alcohol dehydrogenase from a novel subsurface microorganism; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Abigail Sparks, Sandhya Jayasekara, Sandipty Kayastha, Lakshika Dissanayake, Bhagya Sri Kolitha, Lahiru N. Jayakody; Milking yeast: Engineered S. cerevisiae converts waste plastic-derived substrates to casein; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Sandipty Kayastha, Lakshika Dissanayake, Aldwin M. Anterola, Lahiru N. Jayakody; Biosynthesis of indirubin derivatives in Escherichia coli using cytochrome P450 enzymes; 2023 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Lakshika Dissanayake, Sandipty Kayastha, Ryaan Ligon, Abigail Sparks, Sandhya Jayasekara, Lily Becker, Bhagya Sri Kolitha, Lahiru N. Jayakody; Engineering Erwinia aphidicola LJJL01 to produce cis,cis-muconate; ACS Spring 2023
Sandipty Kayastha, Aldwin M. Anterola, Vjollca Konjufca, Poopalasigam Sivakumar, Lakshika Dissanayake, Laxmi Sagwan-Barkdoll, Abigail Sparks, Lahiru N. Jayakody; Engineering of Escherichia coli for the synthesis of novel indirubin derivative; ACS Spring 2023
Lakshika Dissanayake, Sandipty Kayastha, Ryaan Ligon, Abigail Sparks, Ahmad Zatar, Sandhya Jayasekara, Lily Becker, Lahiru Jayakody; Rewiring aromatic catabolism of Erwinia aphidicola LJJL01 to produce high-value platform chemicals; 2022 Research and Creative Activities Forum-Southern Illinois University, Carbondale
Lakshika Dissanayake, Sandipty Kayastha, Ryaan Ligon, Abigail Sparks, Ahmad Zatar, Sandhya Jayasekara, Lily Becker, Lahiru Jayakody; Bioconversion of lignin and plastic-derived aromatic compounds by rewiring aromatic catabolism in E. aphidicola LJLJ01; 2022 ACS Midwest Regional Meeting
Lahiru Jayakody, Ken Anderson, Lakshika Dissanayake, Sandipty Kayastha, Derek Perry, Abigail Sparks and Jeffrey Linger; Engineered novel microbial catabolic powerhouse to upcycle plastic; Symposium on Biomaterials, Fuels and Chemicals 2022
Joni Joni, Chris Mandrel, Lakshika Dissanayake, Sandipty Kayastha, Thushari Jayasekera, Poopalasingam Sivakumar, Lahiru Jayakody; Investigating the Effect of Metal-Site Substitutions on Thermal Stability and PET-Depolymerization Activity on Leaf-branch Compost Cutinase (LCC); ACS Fall 2022
Patrick Combs, Lakshika Dissanayake, Bhagya Sri Kolitha, Sandipty Kayastha, Lahiru N. Jayakody; Functional expression of a dual enzyme system for PET degradation in Erwinia aphidicola LJJL01; REU program 2022
Lakshika Dissanayake, Sandipty Kayastha, Juling Zefo, Peter Langridge, Isaac Shaw, Danielle Neal, Ryaan Ligon, Lahiru Jayakody; Engineering Erwinia aphidicola enables the End- of-Life of polyethylene terephthalate. Research and Creative Activities Forum-Southern Illinois University, Carbondale 2021
Lakshika Dissanayake, Sandipty Kayastha, Juling Zefo, Peter Langridge, Isaac Shaw, Danielle Neal, Ryaan Ligon, Jeffrey Linger, Lahiru Jayakody; Developing Erwinia aphidicola as a Microbial Chassis for Upcycling Polyethylene Terephthalate; ASM World Microbe Forum 2021
Lakshika Dissanayake, Isaac Shaw, Peter Langridge, Juling Zefo, Ryaan Ligon, Sandipty Kayastha, Scott Hamilton-Brehm, Ken Anderson, Lahiru Jayakody; Mining Subsurface Microbial Genetic Traits to Develop Robust Cell Factories for High-Toxic Waste Valorization; Symposium on Biomaterials, Fuels and Chemicals 2021
Isaac Shaw, Peter Langridge, Juling Zefo, Ryaan Ligon, Lakshika Dissanayake, Sandipty Kayastha, Scott Hamilton-Brehm, Lahiru Jayakody; Mining subsurface microbial genetic traits to develop robust microbial cell factories; Research and Creative Activities Forum- Southern Illinois University, Carbondale 2021
Sandipty Kayastha; Lakshika Dissanayake; Laxmi Sagwan-Barkdoll; Poopalasingam Sivakumar; Aldwin Anterola; Lahiru Jayakody; Microbial production of water-soluble Indirubin-derivatives using novel P450 enzymes; Research and Creative Activities Forum- Southern Illinois University, Carbondale 2021
Kurtis Sanders, Thushari Jayasekera, Lakshika Dissanayake, Lahiru Jayakody; In silico-guided engineering of efficient PET depolymerizing enzymes; Research and Creative Activities Forum-Southern Illinois University, Carbondale 2021
Dhanesha Nanayakkara, Iresha Edirisingha, Lakshika Dissanayake, Deepika Weerasinghe, Lalith Suriyagoda, Venura Herath, Chandrika Perera, Dimanthi Jayatilake; A High Throughput Molecular Marker Assay for Screening Bacterial Leaf Blight Resistance in Rice; Peradeniya University International Research Sessions IPURSE 2019

Workshop on Molecular Taxonomy, Phylogeny, Molecular Genetics & Molecular Epidemiology & Evolution
2026
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“Writing an impactful research paper”
2026
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“Scientific Abstracting - Abstracting Science”
2026
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Annual Congress of Postgraduate Institute of Agriculture of University of Peradeniya
2026
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