Dr. Marielena Vogel Saivish Vogel Saivish
About me
Marielena Vogel Saivish is a Brazilian biomedical scientist and virologist specializing in emerging and neglected arboviruses. She earned her PhD in Health Sciences from the School of Medicine of São José do Rio Preto, Brazil, with part of her doctoral research conducted abroad through the FAPESP BEPE fellowship. Her research focuses on the molecular characterization of arboviruses, antiviral discovery, and viral immunology, integrating experimental and computational approaches. She has authored numerous peer-reviewed publications in international journals and currently conducts research at the University of Texas Medical Branch (USA), contributing to efforts to better understand and combat emerging viral diseases that disproportionately affect tropical and developing regions.
Marielena Vogel Saivish is a Brazilian biomedical scientist and virologist whose research focuses on emerging and neglected arboviruses that disproportionately affect tropical and developing regions. She holds a Bachelor’s degree in Biomedical Sciences and a Master’s degree in Applied Health Sciences from the Federal University of Goiás, Brazil, and a PhD in Health Sciences from the School of Medicine of São José do Rio Preto (FAMERP). During her doctoral training, she conducted part of her research abroad through the São Paulo Research Foundation (FAPESP) BEPE fellowship, strengthening international scientific collaboration and research capacity. Her research integrates experimental virology, molecular biology, immunology, and computational approaches to investigate the biology, evolution, and pathogenic potential of arboviruses, particularly neglected flaviviruses. Her work includes the molecular characterization of emerging viruses, the identification of antiviral compounds from natural products, and the application of immunoinformatics and structural biology tools to support antiviral and diagnostic development. Dr. Saivish has authored numerous peer-reviewed scientific publications in international journals and has contributed to collaborative research addressing major challenges in infectious diseases and global health. Currently based at the University of Texas Medical Branch (USA), her research continues to advance understanding of emerging viral threats and to support the development of strategies to mitigate the impact of arboviral diseases worldwide.
Degrees:
Rocio Virus: An Updated View on an Elusive Flavivirus.
Viruses, 2021, 13, 2293.
DOI: https://doi.org/10.3390/v13112293
2. COSTA, V. G.; SAIVISH, M. V.; OLIVEIRA, P. G.; SILVA-JÚNIOR, A.; MORELI, M. L.; KRÜGER, R. H.
First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil.
Scientific Reports, 2021, 11, 11151.
DOI: https://doi.org/10.1038/s41598-021-90672-2
3. SAIVISH, M. V.; MENEZES, G. L.; COSTA, V. G.; SILVA, G. C. D.; MARQUES, R. E.; NOGUEIRA, M. L.; SILVA, R. A.
Predicting Antigenic Peptides from Rocio Virus NS1 Protein for Immunodiagnostic Testing Using Immunoinformatics and Molecular Dynamics Simulation.
International Journal of Molecular Sciences, 2022, 23, 7681.
DOI: https://doi.org/10.3390/ijms23147681
4. MENEZES, G. L.; VOGEL SAIVISH, M.; NOGUEIRA, M. L.; ALVES DA SILVA, R.
Virtual screening of small natural compounds against NS1 protein of DENV, YFV and ZIKV.
Journal of Biomolecular Structure and Dynamics, 2022.
DOI: https://doi.org/10.1080/07391102.2022.2051485
5. SAIVISH, M. V.; MENEZES, G. L.; ALVES DA SILVA, R.; FONTOURA, M. A.; SHIMIZU, J. F.; DUTRA DA SILVA, G. C.; TEIXEIRA, I. S.; MISTRÃO, N. F.; HERNANDES, V. M.; RAHAL, P.; SACCHETTO, L.; MARQUES, R. E.; NOGUEIRA, M. L.
Antiviral Activity of Quercetin Hydrate against Zika Virus.
International Journal of Molecular Sciences, 2023, 24, 7504.
DOI: https://doi.org/10.3390/ijms24087504
6. SAIVISH, M. V.; PACCA, C. C.; COSTA, V. G.; MENEZES, G. L.; ALVES DA SILVA, R.; NEBO, L.; DUTRA DA SILVA, G. C.; MILHIM, B.; TEIXEIRA, I.; HENRIQUE, T.; MISTRÃO, N.; HERNANDES, V.; ZINI, N.; CARVALHO, A.; FONTOURA, M.; RAHAL, P.; SACCHETTO, L.; MARQUES, R.; NOGUEIRA, M. L.
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro.
Viruses, 2023, 15, 494.
DOI: https://doi.org/10.3390/v15020494
7. SAIVISH, M. V.; MENEZES, G. L.; COSTA, V. G.; NEBO, L.; SILVA, G. C.; PACCA, C. C.; MARQUES, R.; NOGUEIRA, M. L.; SILVA, R. A.
Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
Biophysica, 2023, 3, 71–92.
DOI: https://doi.org/10.3390/biophysica3010005
8. MENEZES, G. L.; SAIVISH, M. V.; SACCHETTO, L.; SILVA, G. C.; TEIXEIRA, I. S.; MISTRÃO, N.; NOGUEIRA, M. L.; OLIVEIRA, J.; BEZERRA, K.; SILVA, R. A.; FULCO, U. L.
Exploring Quercetin Hydrate’s Potential as an Antiviral Treatment for Oropouche Virus.
Biophysica, 2023, 3, 485–500.
DOI: https://doi.org/10.3390/biophysica3030026
9. MANDOVA, T.; SAIVISH, M. V.; LA SERRA, L.; NOGUEIRA, M. L.; COSTA, F. B.
Identification of Potential Antiviral Hops Compounds against Chikungunya Virus.
International Journal of Molecular Sciences, 2023, 24, 4568.
DOI: https://doi.org/10.3390/ijms24054568
10. MANDOVA, T.; SAIVISH, M. V.; MENEZES, G. L.; BEZERRA, K.; FULCO, U. L.; ALVES DA SILVA, R.; COSTA, F. B.; NOGUEIRA, M. L.
Antiviral Activity and Molecular Dynamics Simulation of Hops Compounds against Oropouche Virus.
Pharmaceutics, 2023, 15, 821.
DOI: https://doi.org/10.3390/pharmaceutics15030821
11. DA COSTA, V. G.; SAIVISH, M. V.; SINHORINI, P. F.; NOGUEIRA, M. L.; RAHAL, P.
Clinical Landscape and Rate of Exposure to Ilheus Virus: Insights from Systematic Review and Meta-Analysis.
Viruses, 2023, 15, 184.
DOI: https://doi.org/10.3390/v15010184
12. PEINADO, R. S.; MARTINS, L. G.; PACCA, C. C.; SAIVISH, M. V.; BORSATTO, K.; NOGUEIRA, M. L.; TASIC, L.; ARNI, R.; EBERLE, R.; CORONADO, M. A.
HR-MAS NMR Metabolomics Profile of Vero Cells under the Influence of Virus Infection and nsP2 Inhibitor: A Chikungunya Case Study.
International Journal of Molecular Sciences, 2024.
DOI: https://doi.org/10.3390/ijms25042107
13. MENEZES, G. L.; SALES BEZERRA, K.; OLIVEIRA, J.; ARAÚJO, J.; GALVÃO, D.; ALVES DA SILVA, R.; SAIVISH, M. V.; FULCO, U. L.
Quantum Mechanics Insights into Melatonin and Analogs Binding to Melatonin Receptors.
Scientific Reports, 2024.
DOI: https://doi.org/10.1038/s41598-024-59786-x
14. SILVA, G. V.; REINIGER, K.; MENEZES, G.; BEZERRA, K.; GALVÃO, D.; SAIVISH, M. V.; ALVES DA SILVA, R.; AKASH, S.; TAYYEB, J.; OLIVEIRA, J.; FULCO, U. L.
Quantum Mechanical Analysis of Newly Synthesized HIV-1 Protease Inhibitors.
Physical Chemistry Chemical Physics, 2024.
DOI: https://doi.org/10.1039/D4CP02895C
15. SAIVISH, M. V.; NOGUEIRA, M. L.; ROSSI, S. L.; VASILAKIS, N.
Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil.
Viruses, 2024, 16, 336.
DOI: https://doi.org/10.3390/v16030336
16. SAIVISH, M. V.; NOGUEIRA, M. L.; ROSSI, S. L.; VASILAKIS, N.
Exploring Iguape Virus — A Lesser-Known Orthoflavivirus.
Viruses, 2024, 16, 945.
DOI: https://doi.org/10.3390/v16060945
17. SAIVISH, M. V.; MENEZES, G. L.; DA SILVA, R.; ASSIS, L.; TEIXEIRA, I.; FULCO, U. L.; AVILLA, C.; EBERLE, R.; SANTOS, I.; KOROSTOV, K.; WEBBER, M.; NOGUEIRA, M. L.; JARDIM, A.; REGASIN, L.; CORONADO, M.; PACCA, C.
Acridones as promising drug candidates against Oropouche virus.
Current Research in Microbial Sciences, 2024.
DOI: https://doi.org/10.1016/j.crmicr.2024.100198
18. DA COSTA, V. G.; SAIVISH, M. V.; SINHORINI, P.; NOGUEIRA, M. L.; RAHAL, P.
A meta-analysis of Chikungunya virus in neurological disorders.
Infectious Diseases Now, 2024.
DOI: https://doi.org/10.1016/j.idnow.2024.104924
19. SAIVISH, M. V.; DA SILVA, N. I. O.; STECK, M.; MARQUES, R.; NOGUEIRA, M. L.; ROSSI, S. L.
Standardization of Quantitative Plaque-Based Viral Assays for Orthoflavivirus Cacipacoré.
Viruses, 2025.
DOI: https://doi.org/10.3390/v17101355
20. ESTOFOLETE, C. F.; SAIVISH, M. V.; NOGUEIRA, M. L. et al.
From promise to pitfalls: immunological lessons from dengue vaccines and their implications.
npj Vaccines, 2026 (accepted for publication).
DOI: https://doi.org/10.1038/s41541-026-01400-4
Book Chapter
COSTA, V. G.; SAIVISH, M. V. Plant-derived compounds as potential treatment for arboviruses. Academic Press/Elsevier, 2023. https://doi.org/10.1016/B978-0-323-91942-5.00008-2